CourseSource: Resources

Science Behind the Lesson

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X-ploring Fragile X: The Science Behind the Syndrome

Fragile X Syndrome is an X-linked genetic disorder resulting from the impairment of transcription of the FMR1 gene, producing less to no FMRP protein. FMRP is a translational inhibitor that plays a key role in neurological development. Recent...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

epigeneticsgene regulationtranscriptioncentral dogmatranslationFragile X syndromeSphingosine Metabolism

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Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website

Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted toxicities. PharmGKB is an online pharmacogenomics...

Courses: Genetics Toxicology

toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

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My Fish Tank: An Active Learning Activity for Bacterial Nitrogen Metabolism

This active learning activity introduces students to the second part of the nitrogen cycle, nitrification. In terrestrial and aquatic environments, bacteria from the Nitrosomonas and Nitrobacter genera oxidize ammonia first to nitrite (via a...

Courses: Biochemistry and Molecular Biology Ecology Ecology Microbiology

nitrogen cyclenitrificationnitrifying bacteria

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Targeting Misconceptions in the Central Dogma by Examining Viral Infection

Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary connections between DNA structure, transcription,...

Courses: Genetics Introductory Biology

datatranscriptionvirustranslationprotein functionmembrane transportPredictions

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Problem-Based Learning for Physiology: Synthesizing the Cardiovascular System, Respiration, Macronutrient Metabolism, and Renal Function

Problem Based Learning (PBL) is a valuable tool for helping students overcome reliance on memorization by scaffolding opportunities for them to practice the competency of “systems thinking,” which is the ability to understand...

Courses: Anatomy-Physiology

MetabolismObesityblood pressurecardiac functioncardiovascularmetabolic syndromerenalRespirationrespiratory system

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Teaching the Biological Relevance of Chemical Kinetics Using Cold-Blooded Animal Biology

This lesson plan was created to support non-chemistry major students in making connections between chemical kinetics and biological systems. Chemical kinetics is often viewed by students as an abstract topic, and one that is limited only to...

Courses: Introductory Biology Science Process Skills

kineticsMetabolismEctothermPoikilotherm

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Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

Courses: Biochemistry and Molecular Biology

gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

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Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the hood." A solid understanding of how a bioinformatics...

Courses: Biochemistry and Molecular Biology Bioinformatics Introductory Biology

BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix

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From Dirt to Streptomyces DNA

The purpose of this semester-long Lesson is to give students an authentic, course-based undergraduate research experience during which they learn basic and advanced microbiological and molecular biology techniques. This project begins with the...

Courses: Microbiology

MetabolismAntibiotic productionrRNA genesSecondary metabolitesStreptomyces

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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway

Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions. This laboratory lesson helps students to understand the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Microbiology Science Process Skills

SelectionyeastMetabolismcysteinemediamethioninemutantPathwaysulfur

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The Impact of Diet and Antibiotics on the Gut Microbiome: Distance Education Variant

The goal of this article is to describe a variation of an active learning exercise that was previously published by the same author under a similar title. The variation describes modifications instructors can use to make the exercise suitable for...

Courses: Biochemistry and Molecular Biology Microbiology

microbiomenutritionbacterial metabolitesgut bacteriahost response

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Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome

This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

Courses: Biochemistry and Molecular Biology Genetics

gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

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The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation

This active learning exercise introduces students to the plant microbiome and the contributions that bacteria make to plant growth and food production. The Three Sisters are an ancient indigenous practice in which three plant crops and the...

Courses: Microbiology

SymbiosisPlant microbiomeNitrogen fixationNutritional content of foodElectron flowSociety impact of microorganisms

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Discovering Cellular Respiration with Computational Modeling and Simulations

Cellular respiration, a common topic among introductory and cellular biology curricula, is a complex biological process that exemplifies core biological concepts, including systems, pathways and transformation of energy, and structure and function...

Courses: Introductory Biology

Cellular MechanismsCellular RespirationFermentation

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Taking the Hassle out of Hasselbalch

Mention pH in a classroom and you can almost see the inner yawn on the faces of your students. The definition may even roll easily from their lips. However, despite multiple exposures to the relationship of pH and pKa throughout a typical...

Courses: Biochemistry and Molecular Biology Science Process Skills

pHdrug uptakeHenderson-Hasslbalch equationmedical applicationspKa

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The impact of diet and antibiotics on the gut microbiome

The goal of this article is to describe an active learning exercise that can be used in a variety of advanced microbiology courses, including bacterial physiology, ecology, or systems biology. The gut microbiome is a multi-species bacterial...

Courses: Microbiology

microbiomeenvironmental controlhost responsemetabolites

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A Hybrid Virtual Kinesiology Laboratory Module for Human Anatomy and Physiology

The integration of virtual technology is becoming a common trend in anatomy education at the undergraduate and graduate levels. The incorporation of virtual 3D anatomical models into the classroom is beneficial to students, especially if they do...

Courses: Anatomy-Physiology

kinesiologyexercise physiologyAnaerobic RespirationMaximum Oxygen ConsumptionMuscular SystemVirtual AnatomyWingate Test

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A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed a laboratory module to provide a guided research...

Courses: Bioinformatics Cell Biology Developmental Biology Genetics Science Process Skills

microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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Exploring the Complexities of Photosynthesis Through a Comic Strip

Photosynthesis is a conceptually challenging topic. The small scale at which photosynthesis takes place makes it difficult for students to visualize what is occurring, and students are often overwhelmed by all of the details of the process. This...

Courses: Introductory Biology Plant Biology

photosynthesislight-dependent reactionsCalvin cyclechloroplast

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Exploration of the Human Genome by Investigation of Personalized SNPs

Students often shy away from tedious bioinformatics approaches to exploring their genomes. However, in our expanding digital world these skills are some of the most relevant and valuable. To increase students' interest in their own genomes, I...

Courses: Bioinformatics Genetics Science Process Skills