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Electron Location, Location, Location: Understanding Biological Interactions

Introductory Biology courses typically introduce the structure and function of biomolecules such as proteins and nucleic acids. To understand biomolecules fully, students require knowledge of fundamental chemistry concepts such as covalent...

Courses: Biochemistry and Molecular Biology Introductory Biology

hydrogen bondshydrophobicity/hydrophilicitypolar and non-polar covalent bonds

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1967

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503

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A Simple Method for Predicting a Molecule's Biological Properties From Its Polarity

The distinction between very polar and less polar substances is a foundation of biochemistry, cell biology, and physiology; it surfaces in multiple concept inventories and elaborations of biological core concepts. However, in our experience, most...

Courses: Anatomy-Physiology Biochemistry and Molecular Biology Cell Biology Introductory Biology

Diffusionsolubilitycovalent bondshydrophilichydrophobicpartition coefficientplasma membranepolarity

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5075

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680

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Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

Courses: Biochemistry and Molecular Biology Introductory Biology

structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

Teaching Tools and Strategies

2287

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203

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An Interactive Protocol for In-Classroom DNA Extraction

Using commonly available materials, this tool allows students to extract DNA, exploring DNA chemistry and the principles of experimental design and execution. We take a “Choose Your Own Adventure” approach encouraging students to...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

geneticsDNAbiochemical structure and function

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2259

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218

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Sequences and Properties of Gluten Proteins From Different Grains: A Virtual-Friendly Protein Laboratory

The COVID-19 pandemic has forced much university instruction into virtual modes. As a result, many laboratory courses have either dropped content altogether or replaced hands-on activities with simulations and “dry” labs. Our goal was...

Courses: Biochemistry and Molecular Biology Bioinformatics

protein structure and functionProtein sequenceintermolecular forcesBiomacromolecules

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3811

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203

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Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab

Structure and function are correlated at all levels of biology. This topic is typically addressed early in an undergraduate class in general or molecular biology before students have gained much skill or knowledge in molecular biology. However, an...

Courses: Biochemistry and Molecular Biology Introductory Biology

Protein StructureproteaseEnzymechemical bondscatalysissolubility

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1808

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619

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A Close-Up Look at PCR

The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate students often have poor comprehension about the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Science Process Skills

PCRDNA replication

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1262

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401

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Teaching the Biological Relevance of Chemical Kinetics Using Cold-Blooded Animal Biology

This lesson plan was created to support non-chemistry major students in making connections between chemical kinetics and biological systems. Chemical kinetics is often viewed by students as an abstract topic, and one that is limited only to...

Courses: Introductory Biology Science Process Skills

kineticsMetabolismEctothermPoikilotherm

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2976

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401

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It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

Courses: Biochemistry and Molecular Biology

Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases

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719

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251

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A Kinesthetic and Collaborative Activity to Improve Conceptual Understanding of Chemical Equilibrium

While teaching in large lecture halls, it is challenging even for experienced teachers to hold their students’ attention for the entire class period. Owing to the large enrollment in STEM introductory courses, it is especially crucial to...

Courses: Biochemistry and Molecular Biology Science Process Skills

collaborationdemonstrationchemistrykinesthetic learningequilibriumhands-on learning

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373

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21

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Adapting a Traditional Laboratory Exercise to Become Inquiry Based: An Example With an Introductory Biology Lab in Diffusion

Authentic research experiences are effective in fostering self-efficacy and increasing retention in STEM, particularly among minoritized student populations. Many instructors have sought to bring these to a wide range of students in the form of...

Courses: Introductory Biology Science Process Skills

protocolquestionDiffusionVariableshypothesisscience processcontrolscientific efficacy

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3727

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408

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Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformaticsmolecular modelingCOVID19protein structure and functionUCSF ChimeraSARS-CoV-2 spike proteinACE2 receptor

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4423

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754

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Using Yeast to Make Scientists: A Six-Week Student-Driven Research Project for the Cell Biology Laboratory

Traditionally-trained undergraduate students often lack an understanding of science as an active process that yields the information presented in their textbooks. One result has been a call for more research experiences built into traditional...

Courses: Cell Biology Science Process Skills

yeastgrowth curvecell proliferationviability

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3331

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260

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Pesticides in My Smoothie Bowl?

Teaching resources, especially active learning pedagogy, are scarce for toxicology compared to what is available for other disciplines. Ecological and human health risk assessment are important aspects of toxicology and are routinely used by...

Courses: Toxicology

data analysistoxicologychemical toxicityecological risk assessmenthuman risk assessmentpesticide

Teaching Tools and Strategies

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272

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Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination

Sanger sequencing is commonly taught with a hands-on approach. Sanger sequencing involves chain termination by dideoxynucleotides, because they are missing the oxygen on the 3’ carbon atom, which is required for the addition of subsequent...

Courses: Genetics

nucleotidessequencingDNAgel electrophoresisChain Termination

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A simple way for students to visualize cellular respiration: adapting the board game MousetrapTM to model complexity

Lecture-based introductory biology courses are typically content-heavy as instructors strive to provide students with foundational knowledge in a broad range of topics. One topic traditionally covered is cellular respiration, the series of...

Courses: Introductory Biology

ATPGlycolysisCellular RespirationElectron Transport ChainKrebs Cycle

Teaching Tools and Strategies

2443

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295

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A How to Guide and Template for Designing a Puzzle Based Escape Room Game

Educational games are one active and effective way of engaging students with material while also providing additional motivation to tackle challenging concepts. A particularly popular game concept is the escape room, where students need to work in...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Evolution Genetics Science Process Skills

Problem SolvingCollaborative WorkCorrect Misconceptions

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1133

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Meiosis: A Play in Three Acts, Starring DNA Sequence

Meiosis is well known for being a sticky topic that appears repeatedly in biology curricula. We observe that a typical undergraduate biology major cannot correctly identify haploid and diploid cells or explain how and why chromosomes pair before...

Courses: Cell Biology Genetics Introductory Biology

recombinationmeiosisDNA sequenceCrossingoverchromosome structureHolliday junctionhomology

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2881

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527

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An Original-Design Board Game to Increase Student Comprehension of Cellular Respiration Pathways

Cellular respiration is a daunting topic for many students in introductory biology courses. Students are challenged at conceptual and factual levels, since instruction covers multiple metabolic pathways occurring across different cellular...

Courses: Biochemistry and Molecular Biology Cell Biology Introductory Biology Science Process Skills

GlycolysisCellular RespirationFermentationKrebs CycleOxidative phosphorylationpyruvate oxidation

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2997

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197

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The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation

This active learning exercise introduces students to the plant microbiome and the contributions that bacteria make to plant growth and food production. The Three Sisters are an ancient indigenous practice in which three plant crops and the...

Courses: Microbiology

SymbiosisPlant microbiomeNitrogen fixationNutritional content of foodElectron flowSociety impact of microorganisms

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Electron Location, Location, Location: Understanding Biological Interactions

A Simple Method for Predicting a Molecule's Biological Properties From Its Polarity

Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

An Interactive Protocol for In-Classroom DNA Extraction

Sequences and Properties of Gluten Proteins From Different Grains: A Virtual-Friendly Protein Laboratory

Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab

A Close-Up Look at PCR

Teaching the Biological Relevance of Chemical Kinetics Using Cold-Blooded Animal Biology

It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

A Kinesthetic and Collaborative Activity to Improve Conceptual Understanding of Chemical Equilibrium

Adapting a Traditional Laboratory Exercise to Become Inquiry Based: An Example With an Introductory Biology Lab in Diffusion

Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

Using Yeast to Make Scientists: A Six-Week Student-Driven Research Project for the Cell Biology Laboratory

Pesticides in My Smoothie Bowl?

Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination

A simple way for students to visualize cellular respiration: adapting the board game MousetrapTM to model complexity

A How to Guide and Template for Designing a Puzzle Based Escape Room Game

Meiosis: A Play in Three Acts, Starring DNA Sequence

An Original-Design Board Game to Increase Student Comprehension of Cellular Respiration Pathways

The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation

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