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    1763

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    Using a Sequential Interpretation of Data in Envelopes (SIDE) approach to identify a mystery TRP channel
    This lesson sought to engage students in data interpretation and to encourage critical thinking about neurophysiology in the context of temperature sensation. A family of receptors called Transient Receptor Potential (TRP) channels are activated...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Cell BiologyCell Biology NeurobiologyNeurobiology

    Cell communicationChannel specificity and activationLimitations of tools of Cell BiologyNeuronal Signaling
    Lesson
    1220

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    556

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    Understanding Gastric Acid Secretion: An Active Learning Approach
    The human digestive system is a diverse network of cells, tissues, and organs that is regulated by systemic (e.g., nervous and endocrine systems) and local factors (e.g., secretions, pH, and the microbiome). Given the volume of content and the...

    Courses: Anatomy-PhysiologyAnatomy-Physiology

    diseasesignal transductionAcid SecretionAutonomic Nervous SystemEndocrineGastric PhysiologyGPCRHistology of Gastric Pit
    Lesson
    986

    views

    182

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    1

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    From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design
    Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important challenge is how we design curricula to foster...

    Courses: Developmental BiologyDevelopmental Biology

    experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish
    Lesson
    5292

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    693

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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate
    Lesson
    2234

    views

    321

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    Good Drug, Bad Practice: Tackling the Ivermectin Fiasco
    Throughout history, biomedical advancements have alleviated suffering worldwide and significantly advanced human well-being. As researchers and educators, we are well-familiar with the painstakingly slow and meticulous process of science, some of...

    Courses: Anatomy-PhysiologyAnatomy-Physiology NeurobiologyNeurobiology Science Process SkillsScience Process Skills

    Peer reviewCOVID19fraudtherapeutic drugIvermectin
    Lesson
    5558

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    2662

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    0

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    Cell Signaling Pathways - a Case Study Approach
    Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

    Courses: Cell BiologyCell Biology Developmental BiologyDevelopmental Biology

    signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity
    Lesson
    3023

    views

    405

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    It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.
    Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases
    Lesson
    2709

    views

    282

    downloads

    1

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    The Leaky Neuron: Understanding synaptic integration using an analogy involving leaky cups
    Students have difficulty understanding synaptic integration in neural circuits, and how spatial and temporal summation combine in a target neuron to reach threshold.  This Lesson uses small cups of water to represent excitatory postsynaptic...

    Courses: NeurobiologyNeurobiology

    neuron physiologyspatial summationsynaptic integrationtemporal summationthreshold
    Lesson
    1149

    views

    183

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    0

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    Fatty Acid Induction of Lipid Droplets in Cancer Cells
    There is a growing need for the development and communication of cell culture-based laboratory activities specifically designed for undergraduate students. This multi-week laboratory activity allows students to take part in the planning,...

    Courses: Cell BiologyCell Biology Science Process SkillsScience Process Skills

    Course based undergraduate researchCell ImagingLive Cell Staining
    Lesson
    415

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    33

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    Osmosis Through the Lens of Sexual Health
    Osmosis contributes to a range of biological phenomena, from functioning of nephrons in animals to stomatal opening and closing in plants; yet, scientifically simple ideas about osmosis are common. These ideas limit learners’ comprehension...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Cell BiologyCell Biology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    OsmosisDiffusionsexual healthsocial and cultural embeddedness of scienceinclusive dialogue
    Lesson
    907

    views

    55

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    A Structured Inquiry-Based Module for the Undergraduate Cell Biology Laboratory That Teaches Fundamental Concepts of Cell Differentiation
    Pedagogical research in science education has shown that students effectively learn science by doing science. As a result, there is increased interest in bringing research-like experiences into the classroom, particularly for laboratory courses....

    Courses: Cell BiologyCell Biology

    fluorescence microscopygene expressionpolymerase chain reactionCell Structurecell culturewestern blottingdifferentiationreverse transcription
    Lesson
    3505

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    1299

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    A CRISPR/Cas Guide RNA Design In Silico Activity
    CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics

    bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico
    Lesson
    2013

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    573

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    Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans
    Incorporating authentic research experiences into undergraduate labs, while shown to be particularly effective at engaging and retaining students in STEM majors, can be difficult to accomplish within the constraints of resource availability or...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    gene regulationmicroRNAsgene expression
    Lesson
    3549

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    263

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    SEAS CURE: Exploring Coral Biology Across Scales
    Complex biological concepts (like symbiosis and coral biology) that span multiple scales and cross disciplinary boundaries are often difficult for students to understand. This complexity is compounded by the challenges inherent to teaching and...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Cell BiologyCell Biology EcologyEcology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    microscopyAnatomySymbiosisMetabolismbleachinginvertebratedinoflagellate
    Lesson
    1566

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    300

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    Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course
    Metagenomics is rapidly evolving due to advances in sequencing technologies and bioinformatics, but without proper training to interpret these datasets, student understanding remains limited. Aimed at undergraduate juniors and seniors and graduate...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics EcologyEcology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    microbiome
    Teaching Tools and Strategies
    1736

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    326

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    SCIENCE/Fiction: Modular Template for Class Design
    We present a modular scaffold for designing an introductory seminar using speculative fiction and science papers to welcome university undergraduates to the biology major. A list of twelve possible topics is included, such as Memory, Parasites,...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology NeurobiologyNeurobiology

    geneticscell biologyneurosciencesystems biologyScience Fiction
    Lesson
    4841

    views

    1206

    downloads

    1

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    Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis
    The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

    Courses: GeneticsGenetics

    transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants
    Lesson
    2802

    views

    703

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    Teaching Biodiversity with Museum Specimens in an Inquiry-Based Lab
    In response to the growth of biology datasets and broad efforts to digitize data, an increasingly important skill for science students is the management and analysis of large datasets. We designed an inquiry-based lab module to introduce students...

    Courses: EcologyEcology EvolutionEvolution Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    data analysisnatural historyphylogenyBiodiversitymammalsAllen's RuleBergmann's Ruleecogeographymuseum research
    Lesson
    1482

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    158

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    Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle physics concepts
    Introductory physics courses are required for many programs in the life sciences, yet traditional curricula fail to help students meaningfully connect physical concepts with biological systems.  In this lesson, we describe an activity taught...

    Courses: BioinformaticsBioinformatics MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    quantitative biologyHIVmultiplicity of infectionPoisson DistributionPhysics for biologists
    Lesson
    2982

    views

    349

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    Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding
    This lesson introduces beginning biochemistry students to the concept of a biomolecule binding site, such as a neurotransmitter receptor site or an enzyme active site. A simple organic molecule, the neurotransmitter serotonin, is the focus of the...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    active sitebindingbinding sitehydrogen bondinghydrophobic effectionic interactionsnon-covalent forces