CourseSource: Resources

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2982

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349

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Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding

This lesson introduces beginning biochemistry students to the concept of a biomolecule binding site, such as a neurotransmitter receptor site or an enzyme active site. A simple organic molecule, the neurotransmitter serotonin, is the focus of the...

Courses: Biochemistry and Molecular Biology

active sitebindingbinding sitehydrogen bondinghydrophobic effectionic interactionsnon-covalent forces

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5295

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695

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Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

Courses: Biochemistry and Molecular Biology Introductory Biology

structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

Lesson

3023

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405

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It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

Courses: Biochemistry and Molecular Biology

Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases

Lesson

2973

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612

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

Courses: Genetics Introductory Biology Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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3357

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1180

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0

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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3776

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415

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0

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Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformaticsmolecular modelingCOVID19protein structure and functionUCSF ChimeraSARS-CoV-2 spike proteinACE2 receptor

Lesson

3343

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275

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Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience tailored for junior and senior undergraduate biology...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Microbiology

EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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7669

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1462

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics

bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

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1598

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344

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0

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Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

Courses: Biochemistry and Molecular Biology Cell Biology Developmental Biology Science Process Skills

developmenttranscriptiongene expressionmodel organismembryo

Lesson

4974

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460

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The Avocado Lab: An Inquiry-Driven Exploration of an Enzymatic Browning Reaction

Typical biochemistry labs exploring basic enzyme activity rely on costly, time-consuming protein purification and rarely explore enzyme function in situ. Further, complex purification procedures leave little room for novelty in experimental...

Courses: Biochemistry and Molecular Biology Introductory Biology

enzymescontrolsenzyme inhibition

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2195

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459

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0

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Antibiotic Resistance Genes Detection in Environmental Samples

Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This lab series teaches transferable and universal...

Courses: Introductory Biology Microbiology Science Process Skills

geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry

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986

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182

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1

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From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important challenge is how we design curricula to foster...

Courses: Developmental Biology

experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish

Lesson

2549

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458

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Exploring Miracle Fruit: An Undergraduate Laboratory Exercise on Experimental Design

In recent years, undergraduate biology and biochemistry curricula have seen an increase in the use of course-based undergraduate research experiences (CUREs). CUREs maximize potential student gains when students take an active role in experimental...

Courses: Biochemistry and Molecular Biology Science Process Skills

sensory systemspHProtein shapeTaste

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1239

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373

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The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories

Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and implement due to limited time and resources. We...

Courses: Anatomy-Physiology Genetics

protein structure and functionhuman genetic variationmuscle physiology

Lesson

1444

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393

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0

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Data, Distributions, and Hypotheses: Exploring Diversity and Disturbance in the Tallgrass Prairie

Proper hypothesis generation, data handling, graphing, and communication are essential skills that undergraduate majors in biology are expected to master. However, students rarely get hands-on practice that helps them to effectively develop these...

Courses: Ecology Ecology Plant Biology

Quantitative reasoningRestoration EcologyScience process skillstall grass prairie ecosystem

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1808

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479

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Out of Your Seat and on Your Feet! An adaptable course-based research project in plant ecology for advanced students

University capstone projects can offer science students a rich research experience that illustrates the process of doing scientific research, and can also help students better choose future academic and career pathways. While capstone projects are...

Courses: Ecology Ecology Plant Biology Science Process Skills

statisticsactive learningecologyinterdisciplinaryplantscommunicating sciencegroup workfield workproces of science

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3653

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3319

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Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy disciplines such as molecular biology, where emphasis...

Courses: Biochemistry and Molecular Biology

experimental designcrisprmolecular technique

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3168

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1094

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Squirreling Around for Science: Observing Sciurid Rodents to Investigate Animal Behavior

Hands-on research experiences are important opportunities for students to learn about the nature of inquiry and gain confidence in solving problems. Here, we present an inquiry-based lesson plan that investigates the foraging behavior of sciurid...

Courses: Ecology Ecology Introductory Biology Science Process Skills

foragingbehaviorbehavioral ecologySciuridSquirrelSquirrel-NetTrade-offVigilance

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1140

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148

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Exploring the March to Mars Using 3D Print Models

With the increased availability of 3D printers and open databases containing 3D print files, academic institutions are giving more thought into how such technology can be used in the classroom to further student learning. One way that 3D print...

Courses: Introductory Biology Microbiology Science Process Skills

waterMarsmicroorganismsproperties of life

Lesson

2115

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396

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0

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Integrating Manipulatives and Animations to Visualize Holliday Junctions

The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...

Courses: Biochemistry and Molecular Biology Genetics

dna structureDNA damageDNA recombinationGene crossoverHolliday junction

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Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding

Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The Avocado Lab: An Inquiry-Driven Exploration of an Enzymatic Browning Reaction

Antibiotic Resistance Genes Detection in Environmental Samples

From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Exploring Miracle Fruit: An Undergraduate Laboratory Exercise on Experimental Design

The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories

Data, Distributions, and Hypotheses: Exploring Diversity and Disturbance in the Tallgrass Prairie

Out of Your Seat and on Your Feet! An adaptable course-based research project in plant ecology for advanced students

Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

Squirreling Around for Science: Observing Sciurid Rodents to Investigate Animal Behavior

Exploring the March to Mars Using 3D Print Models

Integrating Manipulatives and Animations to Visualize Holliday Junctions

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