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    Fatty Acid Induction of Lipid Droplets in Cancer Cells
    There is a growing need for the development and communication of cell culture-based laboratory activities specifically designed for undergraduate students. This multi-week laboratory activity allows students to take part in the planning,...
    Lesson
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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...
    Lesson
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    317

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    Differential Gene Expression during Xenopus laevis Development
    In Developmental Biology classes, students are challenged with understanding how differential gene expression guides embryonic development. It can be difficult for students to realize that genes need to be turned on or off at the right time and...
    Lesson
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    289

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    Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    The extracellular matrix (ECM) provides structural support to cells, but also has key roles in mediating cell adhesion, cell signaling, and differentiation. While this topic is discussed in the lecture setting, it is not heavily studied in...
    Lesson
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    A virtual laboratory on cell division using a publicly-available image database
    Cell division is a key concept in cell biology. While there are many popular activities to teach students the stages of mitosis, most make use of simple schematics, cartoons, or textbook diagrams. Others engage students in acting out the stages,...
    Lesson
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    527

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs that disrupt activities associated with mitosis and...
    Essay
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    135

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    Going Remote: An Online Adaptation to Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    In light of the COVID-19 pandemic, instructors have modified materials to transition to a remote learning platform. The challenge for science instructors has been to design lab exercises that incorporate both active and experiential learning. In...
    Lesson
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    190

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    Inexpensive Cell Migration Inquiry Lab using Zebrafish
    Cell migration is an important and interesting topic that has the potential to engage students in cell biology by its intrinsically active nature. However, most ways to investigate cell migration require expensive equipment not typically available...
    Lesson
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    455

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    A Short Laboratory Module to Help Infuse Metacognition during an Introductory Course-based Research Experience
    A core competency identified in Vision and Change for undergraduate biology students is the Ability to Apply the Process of Science. Here, we describe a three-week laboratory module for students in an Introductory Cell and Molecular Biology...
    Lesson
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    A Structured Inquiry-Based Module for the Undergraduate Cell Biology Laboratory That Teaches Fundamental Concepts of Cell Differentiation
    Pedagogical research in science education has shown that students effectively learn science by doing science. As a result, there is increased interest in bringing research-like experiences into the classroom, particularly for laboratory courses....

    Courses: Cell BiologyCell Biology

    Lesson
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    Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory
    Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab technique utilized within immunology and molecular...

    Courses: ImmunologyImmunology

    Lesson
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    315

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    Bad Cell Reception? Using a cell part activity to help students appreciate cell biology, with an improved data plan and no loss in coverage
    With a veritable myriad of cell parts to cover, it is easy for educators to become locked into marathon presentations that become taxing for both the instructor and the students. While we hope and expect that students master this material, the...
    Lesson
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    286

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    You and Your Oral Microflora: Introducing non-biology majors to their “forgotten organ”
    With limited time available for laboratory activities, introductory science courses for non-science majors typically use the laboratory period to reinforce material that was previously presented during lecture. This practice was true of a human...
    Lesson
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    344

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    Investigating Gene Expression and Cell Specialization in Axolotl Embryos
    The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...
    Lesson
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    Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection
    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection to cancer treatment. In this lesson, students...
    Lesson
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    My Fish Tank: An Active Learning Activity for Bacterial Nitrogen Metabolism
    This active learning activity introduces students to the second part of the nitrogen cycle, nitrification. In terrestrial and aquatic environments, bacteria from the Nitrosomonas and Nitrobacter genera oxidize ammonia first to nitrite (via a...
    Lesson
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    Osmosis Through the Lens of Sexual Health
    Osmosis contributes to a range of biological phenomena, from functioning of nephrons in animals to stomatal opening and closing in plants; yet, scientifically simple ideas about osmosis are common. These ideas limit learners’ comprehension...
    Lesson
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    Sex-specific differences in Meiosis: Real-world applications
    In traditional classrooms, students are typically presented with facts that they are asked to memorize and recall during an exam.  The rapid explosion of available scientific facts in recent years has made this model of teaching...
    Lesson
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    Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab
    Structure and function are correlated at all levels of biology. This topic is typically addressed early in an undergraduate class in general or molecular biology before students have gained much skill or knowledge in molecular biology. However, an...
    Lesson
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    Antibiotic Resistance Genes Detection in Environmental Samples
    Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This lab series teaches transferable and universal...