CourseSource: Resources

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491

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Translating Co-Translational Translocation

Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also determines the resulting protein topology, is a complex...

Courses: Cell Biology

Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

Lesson

235

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21

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Protein Import Into the ER: Understanding Experimental Methods for Old and New Cellular Discoveries

Process Oriented Guided Inquiry Learning (POGIL) is an effective approach for group work in STEM courses. POGIL-style lessons foster active learning because they require students to communicate and co-construct knowledge to solve problems. Here,...

Courses: Cell Biology Science Process Skills

Necessary and sufficientsignal sequenceProtein SynthesistrafficER importTranslocation

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2663

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626

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Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication

In order to function correctly, proteins must be localized to a specific subcellular location. We have designed this lesson to use data from the primary literature to teach students about the mechanisms cells use to direct proteins to the...

Courses: Cell Biology Science Process Skills

colocalizationimmunofluorescenceProtein localizationsignal sequencessubcellular fractionationwestern blotting

Lesson

914

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338

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0

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Quantifying Uncertainty and Distinguishing Data Sets in Introductory Physics

Physics labs are moving increasingly to open-ended experiments where students develop experimental physics skills, rather than verify textbook physics concepts. This sequence of activities sets the stage for this new kind of lab early in the...

Courses: Introductory Physics: Calculus-Based

statisticsMeasurementlaboratoryuncertaintypendulumexperimental skills

Lesson

2966

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611

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

Courses: Genetics Introductory Biology Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

Lesson

3080

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737

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by characterizing...

Courses: Genetics Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

Lesson

924

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275

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0

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Population Ecology of the Northern Spotted Owl

The mathematical modeling of populations utilizing field-collected demographic data is an important component of lab curricula in a variety of undergraduate biology lab courses. During the global pandemic brought about by the SARS-CoV-2 virus in...

Courses: Ecology Ecology Introductory Biology

demographyCommunity Ecologypopulation ecologyconservation biologylife tables

Lesson

4838

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1206

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1

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Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

Courses: Genetics

transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants

Lesson

5545

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2661

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Cell Signaling Pathways - a Case Study Approach

Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

Courses: Cell Biology Developmental Biology

signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

Lesson

1903

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474

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0

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Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of people have a predisposition to cancer and how that...

Courses: Genetics Science Process Skills

cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

Lesson

3343

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617

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

Courses: Bioinformatics Genetics Science Process Skills

mutationcentral dogmatranslationframeshift

Lesson

4235

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408

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Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon

The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon is a common theme in introductory biology,...

Courses: Genetics Introductory Biology Microbiology

prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon

Lesson

986

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182

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1

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From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important challenge is how we design curricula to foster...

Courses: Developmental Biology

experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish

Lesson

18760

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406

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A flexible, multi-week approach to plant biology - How will plants respond to higher levels of CO₂?

To help introductory biology students understand how plants will respond to higher levels of CO2, we have created a multi-week module consisting of a series of four related laboratory lessons. These lessons allow students to make connections among...

Courses: Introductory Biology Plant Biology

statisticsplantsphotosynthesiscarbon dioxidecommunicating sciencegroup workResource AllocationRespirationStomata

Lesson

1838

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240

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Bioinformatics is a BLAST: Engaging First-Year Biology Students on Campus Biodiversity Using DNA Barcoding

In order to introduce students to the concept of molecular diversity, we developed a short, engaging online lesson using basic bioinformatics techniques. Students were introduced to basic bioinformatics while learning about local on-campus species...

Courses: Bioinformatics Introductory Biology

geneticsorganismal biologybioinformaticstaxonomyDNA Barcodingspecies concepts

Lesson

3781

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1245

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My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)

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909

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Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy

Analyzing high-throughput DNA sequence data is a fundamental skill in modern biology. However, real and perceived barriers such as massive file sizes, substantial computational requirements, and lack of instructor background knowledge can...

Courses: Biochemistry and Molecular Biology Bioinformatics

bioinformaticsDNA sequenceRNAseqgene expression

Lesson

1564

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300

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Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course

Metagenomics is rapidly evolving due to advances in sequencing technologies and bioinformatics, but without proper training to interpret these datasets, student understanding remains limited. Aimed at undergraduate juniors and seniors and graduate...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Microbiology Science Process Skills

microbiome

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3671

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678

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A Hands-on Introduction to Hidden Markov Models

In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM lesson is part of the BIOL/CS 370...

Courses: Bioinformatics Genetics Science Process Skills

transcriptionexonintronsplicing

Lesson

2812

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680

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0

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The Case of the Missing Strawberries: RFLP analysis

While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory exercises related to molecular genotyping by...

Courses: Genetics Science Process Skills

process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP

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Translating Co-Translational Translocation

Protein Import Into the ER: Understanding Experimental Methods for Old and New Cellular Discoveries

Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication

Quantifying Uncertainty and Distinguishing Data Sets in Introductory Physics

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Population Ecology of the Northern Spotted Owl

Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

Cell Signaling Pathways - a Case Study Approach

Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon

From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

A flexible, multi-week approach to plant biology - How will plants respond to higher levels of CO₂?

Bioinformatics is a BLAST: Engaging First-Year Biology Students on Campus Biodiversity Using DNA Barcoding

My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy

Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course

A Hands-on Introduction to Hidden Markov Models

The Case of the Missing Strawberries: RFLP analysis

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