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    Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function
    As instructors of introductory biology courses for majors and non-majors, we have struggled with teaching the concept of cell structure and function in an engaging way.  However, this is a foundational concept that most biology instructors...

    Courses: Cell BiologyCell Biology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    cell functionCell StructureCellular diversityDynamic cellular functionOrganelle function
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    4856

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    487

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics Science Process SkillsScience Process Skills

    modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology
    Lesson
    6588

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    1637

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for whole...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq
    Lesson
    2065

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    515

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs that disrupt activities associated with mitosis and...

    Courses: Cell BiologyCell Biology Science Process SkillsScience Process Skills

    fluorescence microscopymitosisCell StructureCell ImagingImmunocytochemistryQuantitative microscopySTEM skills
    Lesson
    7896

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    394

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    genomicstranscriptionsignaling
    Lesson
    5196

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    687

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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate
    Lesson
    4437

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    444

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    Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation
    Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)
    Lesson
    2250

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    276

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    1

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    Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon
    The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness of components within a biological process and...

    Courses: Introductory BiologyIntroductory Biology

    prokaryotesgene regulationLac Operoninducible operon
    Lesson
    4157

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    406

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    Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon
    The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon is a common theme in introductory biology,...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology MicrobiologyMicrobiology

    prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon
    Lesson
    1559

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    343

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    Understanding Protein Domains: A Modular Approach
    An understanding of protein structure, function, and interaction is central to biochemistry. One angle into this topic is to engage students in considering protein domains as modules that develop form and execute function semi-independently. Here,...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology Science Process SkillsScience Process Skills

    Protein Structure
    Teaching Tools and Strategies
    3613

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    1716

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics ImmunologyImmunology Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19
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    241

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    Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners
    Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

    Courses: Developmental BiologyDevelopmental Biology GeneticsGenetics

    mathematical modelhomologous recombinationCre/loxgene targeting
    Lesson
    5584

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    1152

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    3

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    Meiosis: A Play in Three Acts, Starring DNA Sequence
    Meiosis is well known for being a sticky topic that appears repeatedly in biology curricula. We observe that a typical undergraduate biology major cannot correctly identify haploid and diploid cells or explain how and why chromosomes pair before...

    Courses: Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    recombinationmeiosisDNA sequenceCrossingoverchromosome structureHolliday junctionhomology
    Lesson
    3023

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    353

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    Discovering Cellular Respiration with Computational Modeling and Simulations
    Cellular respiration, a common topic among introductory and cellular biology curricula, is a complex biological process that exemplifies core biological concepts, including systems, pathways and transformation of energy, and structure and function...

    Courses: Introductory BiologyIntroductory Biology

    Cellular MechanismsCellular RespirationFermentation
    Lesson
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    519

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    Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how scientists are able to unravel the molecular...

    Courses: Cell BiologyCell Biology GeneticsGenetics Science Process SkillsScience Process Skills

    pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis
    Lesson
    3753

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    411

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    Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein
    The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Science Process SkillsScience Process Skills

    bioinformaticsmolecular modelingCOVID19protein structure and functionUCSF ChimeraSARS-CoV-2 spike proteinACE2 receptor
    Lesson
    2083

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    541

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to apply higher-order thinking skills to the central...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype
    Lesson
    1440

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    152

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    The Developmental Origins of Mythology: A Pandemic-Inspired Innovative Developmental Biology Laboratory Exercise
    From an experiential, hands-on perspective, the Developmental Biology Laboratory is easily amenable to a wide range of undergraduate-friendly experiments. Thus, pivoting to a virtual laboratory during the COVID-19 pandemic required significant...

    Courses: Developmental BiologyDevelopmental Biology

    gastrulationaxis formationlimb developmentchimeramidline
    Lesson
    1469

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    156

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    Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle physics concepts
    Introductory physics courses are required for many programs in the life sciences, yet traditional curricula fail to help students meaningfully connect physical concepts with biological systems.  In this lesson, we describe an activity taught...

    Courses: BioinformaticsBioinformatics MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    quantitative biologyHIVmultiplicity of infectionPoisson DistributionPhysics for biologists
    Teaching Tools and Strategies
    1319

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    48

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    Using Constructed Response Questions on High-Stakes Assessments in Large Classes With Limited Support
    Large lecture courses often rely heavily, and sometimes exclusively, on Multiple Choice (MC) exams to assess student learning. Constructed Response (CR) questions, in which students generate their own answers, can provide more insight into student...

    Courses: GeneticsGenetics

    assessmenttestexamLarge classconstructed responseshort answerscoring