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    Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design
    One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy disciplines such as molecular biology, where emphasis...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    experimental designcrisprmolecular technique
    Lesson
    3474

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    1296

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    A CRISPR/Cas Guide RNA Design In Silico Activity
    CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics

    bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico
    Lesson
    4869

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    489

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics Science Process SkillsScience Process Skills

    modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology
    Lesson
    972

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    181

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    1

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    From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design
    Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important challenge is how we design curricula to foster...

    Courses: Developmental BiologyDevelopmental Biology

    experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish
    Teaching Tools and Strategies
    4459

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    466

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    0

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    "I Really Enjoy These Annotations:" Examining Primary Biological Literature Using Collaborative Annotation
    Critically reading and evaluating claims made in the primary literature are vital skills for the future professional and personal lives of undergraduate students. However, the formal presentation of intricate content in primary research articles...

    Courses: Developmental BiologyDevelopmental Biology NeurobiologyNeurobiology

    Stem cellsAdult neurogenesisCRISPR gene editing
    Lesson
    1266

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    165

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    0

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    Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes
    Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills to analyze biological data while understanding the...

    Courses: BioinformaticsBioinformatics

    computationpythonJupyter notebookFunctionscentral dogmaDictionaries
    Lesson
    1585

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    342

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    Investigating Gene Expression and Cell Specialization in Axolotl Embryos
    The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology Developmental BiologyDevelopmental Biology Science Process SkillsScience Process Skills

    developmenttranscriptiongene expressionmodel organismembryo
    Teaching Tools and Strategies
    2163

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    352

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    DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.
    Advances in high-throughput techniques have resulted in a rising demand for scientists with basic bioinformatics skills as well as workshops and curricula that teach students bioinformatics concepts. DNA Detective is a workshop we designed to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics GeneticsGenetics Plant BiologyPlant Biology

    geneticsbioinformaticsDNAgenotypephenotypegenegene annotation
    Lesson
    4073

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    562

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    Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology
    At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors
    Lesson
    1778

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    340

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    0

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    Cutthroat trout in Colorado: A case study connecting evolution and conservation
    Evaluation of evidence is a key process skill for the core competencies of applying the process of science and using quantitative reasoning. This case study enables upper-division biology students to practice these skills by applying evolutionary...

    Courses: EvolutionEvolution GeneticsGenetics Science Process SkillsScience Process Skills

    population geneticsphylogeneticsSpeciationdivergencegene flow
    Lesson
    1884

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    471

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    Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of people have a predisposition to cancer and how that...

    Courses: GeneticsGenetics Science Process SkillsScience Process Skills

    cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene
    Lesson
    3637

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    676

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    A Hands-on Introduction to Hidden Markov Models
    In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM lesson is part of the BIOL/CS 370...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    transcriptionexonintronsplicing
    Lesson
    2201

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    429

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    Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms
    Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell division off balance. Communication of these...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationcancertranscriptioncell cycletranslationOncogenesTumor-suppressorp53Transcription factor
    Teaching Tools and Strategies
    702

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    93

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    A "How-to" Guide For Producing Recorded Interviews
    Now that almost every student carries a camera in their pocket, student-created digital media items can be used to supplement curriculum material and as assessment. Although students can easily record interviews, events, and activities on their...

    Courses: Introductory BiologyIntroductory Biology

    communicationemployabilitygathering data
    Lesson
    2023

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    889

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    Exploration of the Human Genome by Investigation of Personalized SNPs
    Students often shy away from tedious bioinformatics approaches to exploring their genomes. However, in our expanding digital world these skills are some of the most relevant and valuable. To increase students' interest in their own genomes, I...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    UCSC genome browsersingle nucleotide polymorphismGenome wide association studiesGenomic organization
    Lesson
    3387

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    277

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    Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology
    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype
    Lesson
    2931

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    609

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein
    Lesson
    4796

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    1206

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    1

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    Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis
    The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

    Courses: GeneticsGenetics

    transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants
    Essay
    941

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    189

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    0

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    Strategies for developing a science communicator through authentic science writing assignments
    To prepare biology undergraduates to be able to read and evaluate the primary literature, it is beneficial to teach students how to write documents in the style of professional science style manuscripts. By breaking manuscripts into individual...

    Courses: Science Process SkillsScience Process Skills

    communicationPeer reviewscience writing
    Lesson
    3045

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    731

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    0

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression.  This laboratory lesson allows students to conduct original research by characterizing...

    Courses: GeneticsGenetics Science Process SkillsScience Process Skills

    bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein