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    Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website
    Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted toxicities. PharmGKB is an online pharmacogenomics...

    Courses: GeneticsGenetics ToxicologyToxicology

    toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics
    Lesson
    3132

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    501

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    Targeting Misconceptions in the Central Dogma by Examining Viral Infection
    Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary connections between DNA structure, transcription,...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology

    datatranscriptionvirustranslationprotein functionmembrane transportPredictions
    Lesson
    1343

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    122

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    Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism
    A thorough understanding of glycolysis forms a foundation for students to analyze subsequent topics in metabolism, a core competency recognized by multiple national societies for biology and biochemistry. However, when confronted with the names of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    Problem based learningguided inquiryenzymesGlycolysisMetabolismFermentationchemical reactionsCard sorting activityCofactors
    Lesson
    1280

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    404

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    Teaching the Biological Relevance of Chemical Kinetics Using Cold-Blooded Animal Biology
    This lesson plan was created to support non-chemistry major students in making connections between chemical kinetics and biological systems. Chemical kinetics is often viewed by students as an abstract topic, and one that is limited only to...

    Courses: Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    kineticsMetabolismEctothermPoikilotherm
    Lesson
    4464

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    447

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    1

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    Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation
    Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)
    Lesson
    3681

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    270

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    Bringing Pasteur Back to Life: Studying the Biochemistry of Yeast Fermentation Through Discussion Groups and an At-Home Lab
    This hands-on, student-centered biochemistry lesson introduces beginner biochemistry students to the techniques of effectively reading and discussing primary literature, identifying fundamental biological concepts, and applying that knowledge to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    primary literatureexperimentationyeastMetabolismFermentationRespirationequilibrium
    Lesson
    3756

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    283

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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics

    gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway
    Lesson
    2644

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    263

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    Pick Your Poison: A Semester-Long Case Study for Undergraduate Toxicology
    The ability to collate information from diverse scientific resources and effectively employ scientific writing is an essential skill for scientists. This lesson describes a semester-long project entitled “Pick Your Poison,” which is...

    Courses: ToxicologyToxicology

    risk assessmenttoxicologyPharmacologyregulationsdose responseADME
    Lesson
    1676

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    393

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    Taking the Hassle out of Hasselbalch
    Mention pH in a classroom and you can almost see the inner yawn on the faces of your students. The definition may even roll easily from their lips. However, despite multiple exposures to the relationship of pH and pKa throughout a typical...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Science Process SkillsScience Process Skills

    pHdrug uptakeHenderson-Hasslbalch equationmedical applicationspKa
    Lesson
    2088

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    287

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    Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots
    Antimicrobials and their use in the treatment of bacterial infections are a fundamental lesson in all microbiology courses. Typically, cultivation-based methods are used to teach students about antimicrobial testing. A complementary approach...

    Courses: MicrobiologyMicrobiology

    Antimicrobial TestingAntimicrobialsInvertebrate animal models
    Lesson
    2055

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    324

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    The Inside and Outside the Body
    The Inside and Outside the Body activity helps students develop a conceptual understanding of anatomical barriers such as skin and mucus membranes that separate internal cells and fluids from the external environment. This short exercise prepares...

    Courses: Anatomy-PhysiologyAnatomy-Physiology

    structureAnatomybarriers
    Lesson
    2584

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    202

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    A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans
    Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed a laboratory module to provide a guided research...

    Courses: BioinformaticsBioinformatics Cell BiologyCell Biology Developmental BiologyDevelopmental Biology GeneticsGenetics Science Process SkillsScience Process Skills

    microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module
    Lesson
    4281

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    865

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    Exploring the Complexities of Photosynthesis Through a Comic Strip
    Photosynthesis is a conceptually challenging topic. The small scale at which photosynthesis takes place makes it difficult for students to visualize what is occurring, and students are often overwhelmed by all of the details of the process. This...

    Courses: Introductory BiologyIntroductory Biology Plant BiologyPlant Biology

    photosynthesislight-dependent reactionsCalvin cyclechloroplast
    Lesson
    4908

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    495

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics Science Process SkillsScience Process Skills

    modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology
    Lesson
    4281

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    1457

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    Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration
    One key to student success in introductory and cell biology courses is a foundational knowledge of cellular respiration. This is a content area in which students often harbor misconceptions that make cellular respiration particularly challenging...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology Introductory BiologyIntroductory Biology

    data analysisCellular RespirationElectron Transport ChainEnergy transformationsMitochondriaOxidative phosphorylationWeight loss drugs24-dinitrophenol (DNP)
    Lesson
    3155

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    457

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    Small Organisms with Big Consequences: Understanding the Microbial World Around Us
    Creating a hands-on lab that conveys important information while simultaneously allowing for student autonomy can be difficult. This is particularly true for the field of microbiology, in which labs often rely on “recipe-style”...

    Courses: Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    disease transmissionmicrobiologymicrobiomeliterature reviewPeer reviewPathogensHealth and WellnessThe Scientific Method
    Lesson
    2280

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    475

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    A Lesson on Matter and Energy at the Organismal Scale: Linking Patterns and Processes Across Diverse Taxa
    Pathways and transformations of energy and matter (PTEM) are a conceptually challenging but essential component of biological literacy. Curricular gaps about PTEM nevertheless remain; although lessons targeting PTEM at small scales (chemical,...

    Courses: EcologyEcology Introductory BiologyIntroductory Biology

    plantsenergyAnimalsfungimatterorganismal scale
    Lesson
    2635

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    575

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    Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination
    Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make connections to research opportunities and real-world...

    Courses: Cell BiologyCell Biology Developmental BiologyDevelopmental Biology GeneticsGenetics Introductory BiologyIntroductory Biology Plant BiologyPlant Biology

    geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed
    Lesson
    1248

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    65

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    Defining Life: Exploring Creativity, Scientific Discovery, and Biology Core Concepts in a Disciplinary First-Year Seminar
    This unit, Defining Life, engages students in thinking like scientists, applying creativity to science, and learning biology core concepts as they explore the defining characteristics of life. This unit provides an example of a curriculum designed...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    Evolutionbiologycellprocess of science