CourseSource: Resources

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A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed a laboratory module to provide a guided research...

Courses: Bioinformatics Cell Biology Developmental Biology Genetics Science Process Skills

microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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5338

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923

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A clicker-based case study that untangles student thinking about the processes in the central dogma

The central dogma of biology is a foundational concept that provides a scaffold to understand how genetic information flows in biological systems. Despite its importance, undergraduate students often poorly understand central dogma processes (DNA...

Courses: Genetics Introductory Biology

mutationtranscriptionphenotypecentral dogmatranslationDNA replication

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3148

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597

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

Courses: Bioinformatics Genetics Science Process Skills

mutationcentral dogmatranslationframeshift

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1529

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371

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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910

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178

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From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important challenge is how we design curricula to foster...

Courses: Developmental Biology

experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish

Lesson

2826

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303

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A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is more challenging to illustrate complex genetic...

Courses: Developmental Biology Genetics

mutationProtein Structureethicscentral dogmahuman disease

Lesson

1113

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331

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The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories

Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and implement due to limited time and resources. We...

Courses: Anatomy-Physiology Genetics

protein structure and functionhuman genetic variationmuscle physiology

Lesson

7403

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1431

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics

bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

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1141

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Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

Courses: Genetics

transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants

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3268

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653

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A Hands-on Introduction to Hidden Markov Models

In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM lesson is part of the BIOL/CS 370...

Courses: Bioinformatics Genetics Science Process Skills

transcriptionexonintronsplicing

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471

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66

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Promoting Interleaved and Spaced Practice in Anatomy and Physiology Students

Students' academic performance in college can be impacted by varying background experiences and skill levels. This article describes a lesson designed for undergraduate Anatomy and Physiology students to address the challenge instructors face...

Courses: Anatomy-Physiology

Anatomical Terms and DirectionInterleaved PracticeStudy StrategiesSpaced Practice

Teaching Tools and Strategies

800

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Biology from Molecules to Embryos, Interactive Animated Lessons

Visualizing kinetic processes can be an impediment to student mastery of basic science coursework. To remedy this obstacle, I created an educational program called Biology from Molecules to Embryos© (BioME), which provides 28 animated lessons...

Courses: Developmental Biology Genetics Introductory Biology

geneticsBIOMEEmbryologycomputer assisted instructioneducational programeducational videosonline lessonsanimated lessonseducational website

Science Behind the Lesson

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The Science Behind the ACTN3 Polymorphism

A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2)...

Courses: Anatomy-Physiology Genetics

protein structure and functionhuman genetic variationskeletal muscle physiology

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1958

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513

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Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to apply higher-order thinking skills to the central...

Courses: Bioinformatics Genetics Science Process Skills

Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype

Teaching Tools and Strategies

2162

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165

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A Pandemic Pivot: Podcast as an Active Engagement Tool in the Classroom and Beyond

Higher education in STEM undoubtedly integrates the use of technology as a primary mode for content delivery to undergraduate students. This became especially salient throughout the shift to online education during the COVID-19 pandemic. Despite...

Courses: Science Process Skills

VaccinesReplication of virusesCOVID-19 transmission

Review

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Workshop Report: Summer 2020 Virtual CRISPR in the Classroom

As innovations and developments in genome editing technologies using CRISPR-Cas systems progress, the need to disseminate relevant knowledge and build skills among the next generation of young scientists in undergraduate classrooms is vital. Our...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Professional Development and Career Planning

geneticscrisprGenome Analysisgene editingbacterial immunity

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Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism

Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...

Courses: Biochemistry and Molecular Biology Introductory Biology Science Process Skills

exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity

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403

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Using Place-Based Economically Relevant Organisms to Improve Student Understanding of the Roles of Carbon Dioxide, Sunlight, and Nutrients in Photosynthetic Organisms

Biology students require broad preparation for diverse careers including agriculture, natural resource management, and laboratory research. Concurrent with this need, employers are seeking applicants who have the scientific skills that allow them...

Courses: Cell Biology Ecology Ecology Introductory Biology Plant Biology

energyphotosynthesisbiomass

Teaching Tools and Strategies

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360

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Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab

The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab course to an online version in Spring 2020. The lab...

Courses: Genetics Science Process Skills

mutationtranscriptioncrisprtranslation

Lesson

3146

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1118

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

A clicker-based case study that untangles student thinking about the processes in the central dogma

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

How to Find a Gene: Retrieving Information From Gene Databases

From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories

An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

A Hands-on Introduction to Hidden Markov Models

Promoting Interleaved and Spaced Practice in Anatomy and Physiology Students

Biology from Molecules to Embryos, Interactive Animated Lessons

The Science Behind the ACTN3 Polymorphism

Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

A Pandemic Pivot: Podcast as an Active Engagement Tool in the Classroom and Beyond

Workshop Report: Summer 2020 Virtual CRISPR in the Classroom

Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism

Using Place-Based Economically Relevant Organisms to Improve Student Understanding of the Roles of Carbon Dioxide, Sunlight, and Nutrients in Photosynthetic Organisms

Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab

CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

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