CourseSource: Resources

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Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners

Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

Courses: Developmental Biology Genetics

mathematical modelhomologous recombinationCre/loxgene targeting

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5647

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1168

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3

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Meiosis: A Play in Three Acts, Starring DNA Sequence

Meiosis is well known for being a sticky topic that appears repeatedly in biology curricula. We observe that a typical undergraduate biology major cannot correctly identify haploid and diploid cells or explain how and why chromosomes pair before...

Courses: Cell Biology Genetics Introductory Biology

recombinationmeiosisDNA sequenceCrossingoverchromosome structureHolliday junctionhomology

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427

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62

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The Science and Ethics of Gene Drives: An Active Learning Lesson in Genetics

Coursework connecting biology to socially relevant issues and ethical questions can help students think about biology in interdisciplinary terms. Gene drives represent one topic involving both advanced biology concepts and societally relevant...

Courses: Genetics

bioethicsCRISPR/Cas9Genetic modificationGene drives

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2044

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890

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Exploration of the Human Genome by Investigation of Personalized SNPs

Students often shy away from tedious bioinformatics approaches to exploring their genomes. However, in our expanding digital world these skills are some of the most relevant and valuable. To increase students' interest in their own genomes, I...

Courses: Bioinformatics Genetics Science Process Skills

UCSC genome browsersingle nucleotide polymorphismGenome wide association studiesGenomic organization

Lesson

2110

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395

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Integrating Manipulatives and Animations to Visualize Holliday Junctions

The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...

Courses: Biochemistry and Molecular Biology Genetics

dna structureDNA damageDNA recombinationGene crossoverHolliday junction

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4968

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459

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The Avocado Lab: An Inquiry-Driven Exploration of an Enzymatic Browning Reaction

Typical biochemistry labs exploring basic enzyme activity rely on costly, time-consuming protein purification and rarely explore enzyme function in situ. Further, complex purification procedures leave little room for novelty in experimental...

Courses: Biochemistry and Molecular Biology Introductory Biology

enzymescontrolsenzyme inhibition

Teaching Tools and Strategies

2183

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356

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DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.

Advances in high-throughput techniques have resulted in a rising demand for scientists with basic bioinformatics skills as well as workshops and curricula that teach students bioinformatics concepts. DNA Detective is a workshop we designed to...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Plant Biology

geneticsbioinformaticsDNAgenotypephenotypegenegene annotation

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3502

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1299

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A CRISPR/Cas Guide RNA Design In Silico Activity

CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics