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    Grow the Gradient: An interactive countercurrent multiplier game
    The countercurrent multiplier of the loop of Henle in a mammalian kidney is a challenging concept for instructors to teach and for students to learn. We developed an interactive game to support student learning of this dynamic process with a team...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Introductory BiologyIntroductory Biology

    countercurrent multiplierexcretory systemkidneyloop of Henlemembrane transport
    Lesson
    1661

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    245

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    Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners
    Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

    Courses: Developmental BiologyDevelopmental Biology GeneticsGenetics

    mathematical modelhomologous recombinationCre/loxgene targeting
    Teaching Tools and Strategies
    1313

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    308

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    Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination
    Sanger sequencing is commonly taught with a hands-on approach. Sanger sequencing involves chain termination by dideoxynucleotides, because they are missing the oxygen on the 3’ carbon atom, which is required for the addition of subsequent...

    Courses: GeneticsGenetics

    nucleotidessequencingDNAgel electrophoresisChain Termination
    Lesson
    1262

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    185

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    Simulating Cortical Rotation, Axis Induction, and Experimental Embryology in Amphibian Embryos Using Clay Models
    The study of development requires learners to understand spatially complex concepts like embryo anatomy. Embryo anatomy is dynamic over time, and it is often manipulated by researchers in experiments that are fundamental to the field. This spatial...

    Courses: Developmental BiologyDevelopmental Biology

    developmentXenopusfertilizationEmbryologyinductionSymmetry breakingOrganizerCortical rotationPatterning
    Lesson
    3516

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    854

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    Furry with a chance of evolution: Exploring genetic drift with tuco-tucos
    Genetic drift is an important mechanism of evolution, yet undergraduates often fail to understand how it leads to evolutionary change due in part to its random nature. This lesson plan describes a simulation-based activity that allows students to...

    Courses: EvolutionEvolution

    EvolutionGenetic DriftBottle neckFounder effectRandom evolutionary processes
    Lesson
    1052

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    174

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    To Vaccinate or Not to Vaccinate
    To vaccinate or not to vaccinate, that is the question. Much of the recent trend in society against vaccination is that the general population does not understand 1) how vaccines work and 2) how one's vaccination status can influence others....

    Courses: Anatomy-PhysiologyAnatomy-Physiology Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology MicrobiologyMicrobiology

    pathogenELISAimmunityantibodyAntigen
    Lesson
    1086

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    157

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    What do Bone and Silly Putty® have in Common?: A Lesson on Bone Viscoelasticity
    Without the use of real-life examples and models, actively instructing and engaging students in complex physiology topics related to bone biomechanics can be challenging. In our large-enrollment Human Physiology & Anatomy courses at the...

    Courses: Anatomy-PhysiologyAnatomy-Physiology

    structure-functioninjuryAnisotropyHysteresisSkeletal SystemViscoelasticity
    Lesson
    5354

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    702

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    0

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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate
    Lesson
    1152

    views

    149

    downloads

    1

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    Exploring the March to Mars Using 3D Print Models
    With the increased availability of 3D printers and open databases containing 3D print files, academic institutions are giving more thought into how such technology can be used in the classroom to further student learning. One way that 3D print...

    Courses: Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    waterMarsmicroorganismsproperties of life
    Lesson
    6321

    views

    557

    downloads

    2

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    Meiosis Remodeled: Inclusion of New Parts to Poppit Bead Models Enhances Understanding of Meiosis
    A long-standing tradition uses strings of poppit beads of different colors to model meiosis, especially to show how segments of paired homologous chromosomes are recombined. Our use of orthodontic latex bands to model cohesion of sister...

    Courses: Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    meiosischiasma formationchromosome recombination
    Lesson
    2617

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    489

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    A Modeling Exercise in Sexual Selection using a Student-Created Bird Species
    Evolution-centered lessons at the undergraduate level can often be jargon-heavy, propagate misconceptions if taught ineffectively, and be uninteresting to students who may not see the relevancy of such concepts. This activity provides a fun and...

    Courses: EcologyEcology EvolutionEvolution Introductory BiologyIntroductory Biology

    Evolutionfitnesssexual selectionNatural Selectionintersexual selectionmate choice
    Lesson
    1835

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    379

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    Plotting Cranial and Spinal Nerve Pathways in a Human Anatomy Lab
    Hands-on experiences with cadavers, animal dissections, or plastic models are effective at improving student learning and attitudes in human anatomy courses. The hands-on experience allows students to visualize and experiment with anatomical...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Science Process SkillsScience Process Skills

    human anatomyNervous systemBrainCranial nerveNerveSpinal cordSpinal nerve
    Teaching Tools and Strategies
    1218

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    131

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    Undergraduates Learn Evolution Through Teaching Kindergartners About Blind Mexican Cavefish
    The development and implementation of a scientific outreach activity comes with a number of challenges. A successful outreach event must match the sophistication of content to the audience, be engaging, expand the knowledge base for participants,...

    Courses: EcologyEcology EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology

    Evolutionecologymorphologysensory biologycave biologycomparative biologyenvironmental differencesregressive lossstructure and function
    Lesson
    1908

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    644

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    A Close-Up Look at PCR
    The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate students often have poor comprehension about the...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    PCRDNA replication
    Lesson
    1462

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    156

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    The Developmental Origins of Mythology: A Pandemic-Inspired Innovative Developmental Biology Laboratory Exercise
    From an experiential, hands-on perspective, the Developmental Biology Laboratory is easily amenable to a wide range of undergraduate-friendly experiments. Thus, pivoting to a virtual laboratory during the COVID-19 pandemic required significant...

    Courses: Developmental BiologyDevelopmental Biology

    gastrulationaxis formationlimb developmentchimeramidline
    Lesson
    3408

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    1357

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    Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function
    As instructors of introductory biology courses for majors and non-majors, we have struggled with teaching the concept of cell structure and function in an engaging way.  However, this is a foundational concept that most biology instructors...

    Courses: Cell BiologyCell Biology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    cell functionCell StructureCellular diversityDynamic cellular functionOrganelle function
    Lesson
    3067

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    521

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    A Kinesthetic Modeling Activity to Teach PCR Fundamentals
    Most molecular biology and biological sciences students understand that the polymerase chain reaction (PCR) is used to amplify DNA. However, we have found that some students experience conceptual misunderstandings, a lack of detailed comprehension...

    Courses: GeneticsGenetics Science Process SkillsScience Process Skills

    PCR
    Lesson
    3036

    views

    407

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    It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.
    Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases
    Lesson
    3736

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    834

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    0

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    Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition
    Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be difficult for students to grasp when instructed...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    kineticsEnzymecompetitive inhibition
    Lesson
    2175

    views

    668

    downloads

    1

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    Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses
    Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the hood." A solid understanding of how a bioinformatics...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Introductory BiologyIntroductory Biology

    BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix