CourseSource: Resources

Science Behind the Lesson

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The Science Behind the ACTN3 Polymorphism

A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2)...

Courses: Anatomy-Physiology Genetics

protein structure and functionhuman genetic variationskeletal muscle physiology

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The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories

Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and implement due to limited time and resources. We...

Courses: Anatomy-Physiology Genetics

protein structure and functionhuman genetic variationmuscle physiology

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1461

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Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration

One key to student success in introductory and cell biology courses is a foundational knowledge of cellular respiration. This is a content area in which students often harbor misconceptions that make cellular respiration particularly challenging...

Courses: Biochemistry and Molecular Biology Cell Biology Introductory Biology

data analysisCellular RespirationElectron Transport ChainEnergy transformationsMitochondriaOxidative phosphorylationWeight loss drugs24-dinitrophenol (DNP)

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157

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What do Bone and Silly Putty® have in Common?: A Lesson on Bone Viscoelasticity

Without the use of real-life examples and models, actively instructing and engaging students in complex physiology topics related to bone biomechanics can be challenging. In our large-enrollment Human Physiology & Anatomy courses at the...

Courses: Anatomy-Physiology

structure-functioninjuryAnisotropyHysteresisSkeletal SystemViscoelasticity

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2055

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517

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A Simple Method for Predicting a Molecule's Biological Properties From Its Polarity

The distinction between very polar and less polar substances is a foundation of biochemistry, cell biology, and physiology; it surfaces in multiple concept inventories and elaborations of biological core concepts. However, in our experience, most...

Courses: Anatomy-Physiology Biochemistry and Molecular Biology Cell Biology Introductory Biology

Diffusionsolubilitycovalent bondshydrophilichydrophobicpartition coefficientplasma membranepolarity

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Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

Homeostasis and negative feedback are crucial, yet difficult, concepts for undergraduates, particularly in the context of the hypothalamo-pituitary axes. This interactive activity was designed to (1) reveal how negative feedback can restore...

Courses: Anatomy-Physiology

cell-cell communicationhomeostasisnegative feedback

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Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

Courses: Biochemistry and Molecular Biology Cell Biology Developmental Biology Science Process Skills

developmenttranscriptiongene expressionmodel organismembryo

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1997

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Engaging Undergraduates in Mechanisms of Tubular Reabsorption and Secretion in the Mammalian Kidney

If students fail to see the connections among physiological systems, they can become overwhelmed with the amount of information they need to learn. Some students have particular difficulty with the renal system for this reason. This lesson was...

Courses: Anatomy-Physiology Cell Biology

OsmosisActive transportMass flowRenal reabsorptionRenal secretionTransport across membranes

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How Do Kidneys Make Urine From Blood? Qualitative and Quantitative Approaches to Filtration, Secretion, Reabsorption, and Excretion

The function of the kidneys is to help maintain a constant internal environment (homeostasis) by regulating the volume and chemical composition of the blood. This regulation occurs via three fundamental processes: filtration, secretion, and...

Courses: Anatomy-Physiology Introductory Biology

collecting ductexcretionglomerular filtration rate (GFR)nephron tubulereabsorptionrenal corpusclesection

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174

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To Vaccinate or Not to Vaccinate

To vaccinate or not to vaccinate, that is the question. Much of the recent trend in society against vaccination is that the general population does not understand 1) how vaccines work and 2) how one's vaccination status can influence others....

Courses: Anatomy-Physiology Biochemistry and Molecular Biology Introductory Biology Microbiology

pathogenELISAimmunityantibodyAntigen

Essay

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369

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Online Adaptation of the Cell Engineer/Detective Lesson

One of the most fundamental themes of biology is the relationship between structure and function, which is particularly evident when it comes to cells; however, the traditional cartoon depictions of cells that are often used to help teach the...

Courses: Cell Biology Introductory Biology Science Process Skills

cell functionCell StructureOrganelles

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The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation

This active learning exercise introduces students to the plant microbiome and the contributions that bacteria make to plant growth and food production. The Three Sisters are an ancient indigenous practice in which three plant crops and the...

Courses: Microbiology

SymbiosisPlant microbiomeNitrogen fixationNutritional content of foodElectron flowSociety impact of microorganisms

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194

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It's a bird! It's a plane! It's biomechanics!

Biomechanics is a discipline that draws from physics and engineering principles to understand the movement and structure of living organisms. It is highly interdisciplinary in nature and can be incorporated into general biology and ecology...

Courses: Anatomy-Physiology Ecology Ecology Evolution

EvolutionecologybatphysiologyAnatomybirdFlightforcesinsect

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264

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Exploring the City of Biofilms: An Engaging Analogy-Based Activity for Students to Learn Biofilms

Multicellular biofilms constructed by microbes are key aspects of microbiology with significant implications in various fields, including medicine, environmental science, and biotechnology. While bacteria spend nearly all their lives in biofilms,...

Courses: Microbiology

bacteriaBiofilmsquorum sensing

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What's in this? Students Deliberate on Endocrine Disrupting Chemicals Found in Everyday Healthcare Items to Build Democratic Skills

In helping our students become informed and active members of society, it is necessary that they develop certain skills that will empower them to improve their community and governance. These skills include communication, collaboration, and...

Courses: Anatomy-Physiology Cell Biology Developmental Biology Introductory Biology Science Process Skills

cellEndocrinehormones

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Taking the Hassle out of Hasselbalch

Mention pH in a classroom and you can almost see the inner yawn on the faces of your students. The definition may even roll easily from their lips. However, despite multiple exposures to the relationship of pH and pKa throughout a typical...

Courses: Biochemistry and Molecular Biology Science Process Skills

pHdrug uptakeHenderson-Hasslbalch equationmedical applicationspKa

Teaching Tools and Strategies

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A 360˚ View of COVID-19

In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Immunology Introductory Biology Microbiology Science Process Skills

geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

Courses: Biochemistry and Molecular Biology

Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases

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Bringing Pasteur Back to Life: Studying the Biochemistry of Yeast Fermentation Through Discussion Groups and an At-Home Lab

This hands-on, student-centered biochemistry lesson introduces beginner biochemistry students to the techniques of effectively reading and discussing primary literature, identifying fundamental biological concepts, and applying that knowledge to...

Courses: Biochemistry and Molecular Biology Microbiology Science Process Skills

primary literatureexperimentationyeastMetabolismFermentationRespirationequilibrium

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Small Organisms with Big Consequences: Understanding the Microbial World Around Us

Creating a hands-on lab that conveys important information while simultaneously allowing for student autonomy can be difficult. This is particularly true for the field of microbiology, in which labs often rely on “recipe-style”...

Courses: Introductory Biology Microbiology Science Process Skills

disease transmissionmicrobiologymicrobiomeliterature reviewPeer reviewPathogensHealth and WellnessThe Scientific Method

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The Science Behind the ACTN3 Polymorphism

The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories

Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration

What do Bone and Silly Putty® have in Common?: A Lesson on Bone Viscoelasticity

A Simple Method for Predicting a Molecule's Biological Properties From Its Polarity

Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

Investigating Gene Expression and Cell Specialization in Axolotl Embryos

Engaging Undergraduates in Mechanisms of Tubular Reabsorption and Secretion in the Mammalian Kidney

How Do Kidneys Make Urine From Blood? Qualitative and Quantitative Approaches to Filtration, Secretion, Reabsorption, and Excretion

To Vaccinate or Not to Vaccinate

Online Adaptation of the Cell Engineer/Detective Lesson

The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation

It's a bird! It's a plane! It's biomechanics!

Exploring the City of Biofilms: An Engaging Analogy-Based Activity for Students to Learn Biofilms

What's in this? Students Deliberate on Endocrine Disrupting Chemicals Found in Everyday Healthcare Items to Build Democratic Skills

Taking the Hassle out of Hasselbalch

A 360˚ View of COVID-19

It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Bringing Pasteur Back to Life: Studying the Biochemistry of Yeast Fermentation Through Discussion Groups and an At-Home Lab

Small Organisms with Big Consequences: Understanding the Microbial World Around Us

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