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    Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism
    A thorough understanding of glycolysis forms a foundation for students to analyze subsequent topics in metabolism, a core competency recognized by multiple national societies for biology and biochemistry. However, when confronted with the names of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    Problem based learningguided inquiryenzymesGlycolysisMetabolismFermentationchemical reactionsCard sorting activityCofactors
    Lesson
    3515

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    767

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    2

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    "Got Algae?" A Sorting Game for Introducing the Weird and Wonderful Diversity of Algae
    Algae are a fascinating and diverse organismal group, with global ecological importance, a storied evolutionary history and deep connections to both contemporary and historical human societies. Yet non-experts who teach algal diversity face a lack...

    Courses: EcologyEcology EvolutionEvolution Plant BiologyPlant Biology

    phylogenyBiodiversityphotosynthesisalgaeseaweedmonophyly
    Lesson
    2663

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    474

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    Go Extinct! An Award-Winning Evolution Game That Teaches Tree-Thinking as Students Pursue the Winning Strategy
    Evolutionary trees communicate both the diversity and unity of life, a central and important scientific concept, as highlighted by the Vision and Change undergraduate biology education movement. Evolutionary trees and cladograms are diagrams...

    Courses: EvolutionEvolution

    phylogeneticsnatural historyBiodiversitycladogramCommon ancestorEvolutionary treeLand vertebratesMonophyletic cladeTetrapods
    Lesson
    2247

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    449

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    Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms
    Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell division off balance. Communication of these...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationcancertranscriptioncell cycletranslationOncogenesTumor-suppressorp53Transcription factor
    Lesson
    1734

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    470

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    Generating Biological Hypotheses in a "Course-based Undergraduate Research Experience"(CURE) Course
    Hypotheses are often incorrectly defined as educated guesses or if/then statements. Further confusion arises from the fact that not all disciplines define hypotheses similarly. The difficulty in distinguishing between statistical and biological...

    Courses: Science Process SkillsScience Process Skills

    scientific methodHPT axisNeural stem cells
    Lesson
    1228

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    559

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    Understanding Gastric Acid Secretion: An Active Learning Approach
    The human digestive system is a diverse network of cells, tissues, and organs that is regulated by systemic (e.g., nervous and endocrine systems) and local factors (e.g., secretions, pH, and the microbiome). Given the volume of content and the...

    Courses: Anatomy-PhysiologyAnatomy-Physiology

    diseasesignal transductionAcid SecretionAutonomic Nervous SystemEndocrineGastric PhysiologyGPCRHistology of Gastric Pit
    Lesson
    2340

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    229

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    Sequences and Properties of Gluten Proteins From Different Grains: A Virtual-Friendly Protein Laboratory
    The COVID-19 pandemic has forced much university instruction into virtual modes. As a result, many laboratory courses have either dropped content altogether or replaced hands-on activities with simulations and “dry” labs. Our goal was...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics

    protein structure and functionProtein sequenceintermolecular forcesBiomacromolecules
    Lesson
    2024

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    177

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    Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism
    Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity
    Lesson
    4395

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    1262

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    What is Speciation, How Does It Occur, and Why Is It Important for Conservation?
    Speciation provides a framework for classifying biodiversity on Earth and is a central concept in evolutionary biology. To help undergraduate students learn about speciation, we designed a student-centered lesson that uses active-learning...

    Courses: EcologyEcology GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    EvolutionconservationGenetic DriftSpeciationNatural SelectionBiological species conceptgene flowMorphological species conceptPhylogenetic species concept
    Lesson
    3362

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    270

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    Pesticides in My Smoothie Bowl?
    Teaching resources, especially active learning pedagogy, are scarce for toxicology compared to what is available for other disciplines. Ecological and human health risk assessment are important aspects of toxicology and are routinely used by...

    Courses: ToxicologyToxicology

    data analysistoxicologychemical toxicityecological risk assessmenthuman risk assessmentpesticide
    Essay
    836

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    126

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    Implementing active learning approaches into an upper-division biology course
    In this essay, we present our strategy for implementing active learning strategies into an upper division course on Human Genetics. Our principal goal was to shift from a traditional didactic course design, to one that more clearly placed the...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology

    human biologyPedigree analysisRare genetic diseases
    Lesson
    787

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    259

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    A Kinesthetic and Collaborative Activity to Improve Conceptual Understanding of Chemical Equilibrium
    While teaching in large lecture halls, it is challenging even for experienced teachers to hold their students’ attention for the entire class period. Owing to the large enrollment in STEM introductory courses, it is especially crucial to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Science Process SkillsScience Process Skills

    collaborationdemonstrationchemistrykinesthetic learningequilibriumhands-on learning
    Lesson
    1260

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    184

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    Simulating Cortical Rotation, Axis Induction, and Experimental Embryology in Amphibian Embryos Using Clay Models
    The study of development requires learners to understand spatially complex concepts like embryo anatomy. Embryo anatomy is dynamic over time, and it is often manipulated by researchers in experiments that are fundamental to the field. This spatial...

    Courses: Developmental BiologyDevelopmental Biology

    developmentXenopusfertilizationEmbryologyinductionSymmetry breakingOrganizerCortical rotationPatterning
    Lesson
    3036

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    407

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    It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.
    Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases
    Lesson
    1903

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    644

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    A Close-Up Look at PCR
    The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate students often have poor comprehension about the...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    PCRDNA replication
    Lesson
    3730

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    833

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    Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition
    Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be difficult for students to grasp when instructed...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    kineticsEnzymecompetitive inhibition
    Teaching Tools and Strategies
    1309

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    307

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    Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination
    Sanger sequencing is commonly taught with a hands-on approach. Sanger sequencing involves chain termination by dideoxynucleotides, because they are missing the oxygen on the 3’ carbon atom, which is required for the addition of subsequent...

    Courses: GeneticsGenetics

    nucleotidessequencingDNAgel electrophoresisChain Termination
    Teaching Tools and Strategies
    1218

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    131

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    Undergraduates Learn Evolution Through Teaching Kindergartners About Blind Mexican Cavefish
    The development and implementation of a scientific outreach activity comes with a number of challenges. A successful outreach event must match the sophistication of content to the audience, be engaging, expand the knowledge base for participants,...

    Courses: EcologyEcology EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology

    Evolutionecologymorphologysensory biologycave biologycomparative biologyenvironmental differencesregressive lossstructure and function
    Lesson
    5743

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    986

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    A clicker-based case study that untangles student thinking about the processes in the central dogma
    The central dogma of biology is a foundational concept that provides a scaffold to understand how genetic information flows in biological systems. Despite its importance, undergraduate students often poorly understand central dogma processes (DNA...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationtranscriptionphenotypecentral dogmatranslationDNA replication
    Lesson
    3406

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    1355

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    Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function
    As instructors of introductory biology courses for majors and non-majors, we have struggled with teaching the concept of cell structure and function in an engaging way.  However, this is a foundational concept that most biology instructors...

    Courses: Cell BiologyCell Biology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    cell functionCell StructureCellular diversityDynamic cellular functionOrganelle function