CourseSource: Resources

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3013

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445

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Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

In evolution classrooms, introducing and reinforcing the idea of genetic drift and random selection can be challenging, as can be reinforcing appropriate mental models of evolution. Agent-based models offer students the opportunity to conduct a...

Courses: Bioinformatics Ecology Ecology Evolution Science Process Skills

modelingEvolutionecologyagent-based modelingGenetic Driftenvironmental scienceNatural Selectioncompetitive coevolutionsimulation modelingevolutionary reasoning

Lesson

4332

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436

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1

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Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

Courses: Biochemistry and Molecular Biology

gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

Lesson

1116

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160

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0

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Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

Homeostasis and negative feedback are crucial, yet difficult, concepts for undergraduates, particularly in the context of the hypothalamo-pituitary axes. This interactive activity was designed to (1) reveal how negative feedback can restore...

Courses: Anatomy-Physiology

cell-cell communicationhomeostasisnegative feedback

Lesson

1190

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175

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0

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Simulating Cortical Rotation, Axis Induction, and Experimental Embryology in Amphibian Embryos Using Clay Models

The study of development requires learners to understand spatially complex concepts like embryo anatomy. Embryo anatomy is dynamic over time, and it is often manipulated by researchers in experiments that are fundamental to the field. This spatial...

Courses: Developmental Biology

developmentXenopusfertilizationEmbryologyinductionSymmetry breakingOrganizerCortical rotationPatterning

Lesson

3574

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800

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0

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Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition

Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be difficult for students to grasp when instructed...

Courses: Biochemistry and Molecular Biology Cell Biology

kineticsEnzymecompetitive inhibition

Lesson

2906

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501

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0

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A Kinesthetic Modeling Activity to Teach PCR Fundamentals

Most molecular biology and biological sciences students understand that the polymerase chain reaction (PCR) is used to amplify DNA. However, we have found that some students experience conceptual misunderstandings, a lack of detailed comprehension...

Courses: Genetics Science Process Skills

PCR

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1869

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323

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0

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Modeling the Research Process: Authentic human physiology research in a large non-majors course

Laboratory experiences in large-enrollment introductory science courses often utilize “cookie-cutter style” laboratory experiences due to the relative simplicity of setting up the lab stations, as well as a need to teach students...

Courses: Anatomy-Physiology Introductory Biology Neurobiology Science Process Skills

data analysishypothesis testingexperimental designphysiology

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998

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164

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0

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To Vaccinate or Not to Vaccinate

To vaccinate or not to vaccinate, that is the question. Much of the recent trend in society against vaccination is that the general population does not understand 1) how vaccines work and 2) how one's vaccination status can influence others....

Courses: Anatomy-Physiology Biochemistry and Molecular Biology Introductory Biology Microbiology

pathogenELISAimmunityantibodyAntigen

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6317

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1073

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0

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Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Science Process Skills

geneticsbioinformaticsdrosophilachi-square analysiscomplementation mappingmode of inheritancethree-point mapping

Lesson

3287

views

1320

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0

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Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function

As instructors of introductory biology courses for majors and non-majors, we have struggled with teaching the concept of cell structure and function in an engaging way. However, this is a foundational concept that most biology instructors...

Courses: Cell Biology Introductory Biology Science Process Skills

cell functionCell StructureCellular diversityDynamic cellular functionOrganelle function

Lesson

1779

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613

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0

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A Close-Up Look at PCR

The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate students often have poor comprehension about the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Science Process Skills

PCRDNA replication

Teaching Tools and Strategies

2746

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381

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0

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The Flight Physics Concept Inventory: Reliably Evaluating Aerodynamic Lift, Drag and Associated (Naïve) Concepts of Flight in Class and In-Game

Students often struggle to transfer conceptual understanding from isolated instruction to a coherent mental model. This is especially true for the context of flight physics, fluid dynamics, or the concepts of aerodynamic lift, drag, stall, center...

Courses: Introductory Physics: Calculus-Based

active learninggamificationmisconceptionsaerodynamicsfluid dynamicsResearch-based assessment instrumentConceptual SurveyPRE-/POST-test

Lesson

2936

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394

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0

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It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

Courses: Biochemistry and Molecular Biology

Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases

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3388

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713

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0

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Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

Constructing a robust understanding of homologous chromosomes, sex chromosomes, and the particulate nature of genes is a notoriously difficult task for undergraduate biology students. In this lesson, students expand their knowledge of human...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

bioinformaticsautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations

Teaching Tools and Strategies

1218

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267

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0

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Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination

Sanger sequencing is commonly taught with a hands-on approach. Sanger sequencing involves chain termination by dideoxynucleotides, because they are missing the oxygen on the 3’ carbon atom, which is required for the addition of subsequent...

Courses: Genetics

nucleotidessequencingDNAgel electrophoresisChain Termination

Lesson

4909

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892

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Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy

Analyzing high-throughput DNA sequence data is a fundamental skill in modern biology. However, real and perceived barriers such as massive file sizes, substantial computational requirements, and lack of instructor background knowledge can...

Courses: Biochemistry and Molecular Biology Bioinformatics

bioinformaticsDNA sequenceRNAseqgene expression

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7540

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1450

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics

bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

Lesson

1911

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273

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0

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A CURE-based approach to teaching genomics using mitochondrial genomes

There is an abundance (currently over 1016 DNA bases) of publicly available genetic sequence data and a dearth of trained genomicists to process and interpret it, necessitating more trained bioinformaticians with biological expertise. For...

Courses: Bioinformatics Genetics

proteinsMitochondrial GenomesNuclear GenomesrRNAtRNA

Teaching Tools and Strategies

1177

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129

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0

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Undergraduates Learn Evolution Through Teaching Kindergartners About Blind Mexican Cavefish

The development and implementation of a scientific outreach activity comes with a number of challenges. A successful outreach event must match the sophistication of content to the audience, be engaging, expand the knowledge base for participants,...

Courses: Ecology Ecology Evolution Genetics Introductory Biology

Evolutionecologymorphologysensory biologycave biologycomparative biologyenvironmental differencesregressive lossstructure and function

Lesson

3829

views

403

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0

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Using Place-Based Economically Relevant Organisms to Improve Student Understanding of the Roles of Carbon Dioxide, Sunlight, and Nutrients in Photosynthetic Organisms

Biology students require broad preparation for diverse careers including agriculture, natural resource management, and laboratory research. Concurrent with this need, employers are seeking applicants who have the scientific skills that allow them...

Courses: Cell Biology Ecology Ecology Introductory Biology Plant Biology

energyphotosynthesisbiomass

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Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

Simulating Cortical Rotation, Axis Induction, and Experimental Embryology in Amphibian Embryos Using Clay Models

Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition

A Kinesthetic Modeling Activity to Teach PCR Fundamentals

Modeling the Research Process: Authentic human physiology research in a large non-majors course

To Vaccinate or Not to Vaccinate

Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function

A Close-Up Look at PCR

The Flight Physics Concept Inventory: Reliably Evaluating Aerodynamic Lift, Drag and Associated (Naïve) Concepts of Flight in Class and In-Game

It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination

Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy

An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

A CURE-based approach to teaching genomics using mitochondrial genomes

Undergraduates Learn Evolution Through Teaching Kindergartners About Blind Mexican Cavefish

Using Place-Based Economically Relevant Organisms to Improve Student Understanding of the Roles of Carbon Dioxide, Sunlight, and Nutrients in Photosynthetic Organisms

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