CourseSource: Resources

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An Active Textbook Converts "Vision and Tweak" to Vision and Change

Multiple reports over more than a century have documented the problems with the way introductory biology has been taught in most colleges and universities. An influential recent report, Vision and Change in Undergraduate Biology Education, has...

Courses: Introductory Biology

Vision and Changeactive learningintroductory biologyFlipped classroomUndergraduatecore competenciescore conceptsactive textbookcurriculum reform

Lesson

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334

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Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website

Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted toxicities. PharmGKB is an online pharmacogenomics...

Courses: Genetics Toxicology

toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

Lesson

1407

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106

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Introducing Immunology Research Literature to Understand B-cell Receptor Gene Expression

Immunology is relevant to our everyday lives, driving a need for more engaging and inclusive undergraduate immunology education. One way to engage a diverse group of learners is by teaching them how to read and interpret the scientific literature....

Courses: Immunology Science Process Skills

recombinationantibodyV(D)J recombinationB-cell receptorlymphocyte receptor

Lesson

1158

views

380

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Your Tax Dollars at Work: A mock grant writing experience centered on scientific process skills

A successful scientist combines skill, creativity, and the art of persuasion to excel in his or her field of study. Critically important for the professional scientist is the ability to not only conduct research, but also to conceive a project and...

Courses: Science Process Skills

researchexperimental designprocess of sciencePeer reviewgrant writingPecha Kuchaproposal

Teaching Tools and Strategies

5637

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170

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Walkabout: An Easy to Use, Experiential Learning Activity for Applying Abstract Concepts to the Real-World

Students can have difficulty recognizing examples of course concepts in the real-world. They particularly struggle with phenomena that are ambiguously defined, have mimics, or are hard to distinguish from other phenomena. Students can better...

Courses: Ecology Ecology Science Process Skills

data gatheringgreen technologyobservations

Lesson

2155

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316

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Learning R for Biologists: A Mini Course Grab-Bag for Instructors

As biology becomes more data driven, teaching students data literacy skills has become central to biology curriculum. Despite a wealth of online resources that teach researchers how to use R, there are few that offer practical laboratory-based...

Courses: Anatomy-Physiology Bioinformatics Ecology Ecology Genetics

Rdata analysisRStudio

Lesson

2082

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395

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Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms

Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell division off balance. Communication of these...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

mutationcancertranscriptioncell cycletranslationOncogenesTumor-suppressorp53Transcription factor

Lesson

2506

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622

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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway

Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions. This laboratory lesson helps students to understand the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Microbiology Science Process Skills

SelectionyeastMetabolismcysteinemediamethioninemutantPathwaysulfur

Lesson

2940

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396

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It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

Courses: Biochemistry and Molecular Biology

Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases

Lesson

1198

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158

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Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes

Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills to analyze biological data while understanding the...

Courses: Bioinformatics

computationpythonJupyter notebookFunctionscentral dogmaDictionaries

Lesson

2917

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334

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A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is more challenging to illustrate complex genetic...

Courses: Developmental Biology Genetics

mutationProtein Structureethicscentral dogmahuman disease

Lesson

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1174

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Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

Courses: Genetics

transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants

Lesson

2885

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343

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0

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Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding

This lesson introduces beginning biochemistry students to the concept of a biomolecule binding site, such as a neurotransmitter receptor site or an enzyme active site. A simple organic molecule, the neurotransmitter serotonin, is the focus of the...

Courses: Biochemistry and Molecular Biology

active sitebindingbinding sitehydrogen bondinghydrophobic effectionic interactionsnon-covalent forces

Lesson

4997

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671

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0

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Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

Courses: Biochemistry and Molecular Biology Introductory Biology

structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

Lesson

1951

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337

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Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Many video resources exist to teach Mendelian genetics, but most consist of passive delivery of information rather than active construction of knowledge by users. We have created two interactive video vignettes (IVVs) that can be used together or...

Courses: Genetics Introductory Biology Science Process Skills

genotypephenotypeallelespedigreedominanceHardy-Weinberg equilibriumInheritance

Lesson

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443

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Antibiotic Resistance Genes Detection in Environmental Samples

Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This lab series teaches transferable and universal...

Courses: Introductory Biology Microbiology Science Process Skills

geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry

Teaching Tools and Strategies

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How to Design a Classroom Activity that Integrates 3D Print Models with Active Learning

Student exploration of relevant physical models can deepen knowledge of course material. In this guide we describe a method by which instructors can integrate 3D printing technology with an established teaching strategy, the classroom jigsaw, to...

Courses: Introductory Biology

active learning3D print modelsclassroom jigsaw

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308

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Understanding Host-Pathogen Interactions With the Use of Galleria mellonella

The Galleria mellonella; the larvae of the Greater Wax Moth, is a safe and effective means to study host-pathogen interactions in the undergraduate setting. The use of animal models in the teaching classroom provides an opportunity to discuss...

Courses: Immunology Microbiology

innate immunitybacterial pathogenesisHost-pathogen interactionsGalleria mellonellaVirulence

Lesson

3260

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609

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

Courses: Bioinformatics Genetics Science Process Skills

mutationcentral dogmatranslationframeshift

Teaching Tools and Strategies

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194

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Wikipedia in the Science Classroom

Despite research suggesting that writing-to-learn exercises (WTL) in the classroom are associated with increased student learning, WTL is still not widely implemented in science courses. To provide our students with a meaningful WTL exercise that...

Courses: Introductory Biology Science Process Skills

scientific writingcritical evaluationWikipediawriting for general public

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An Active Textbook Converts "Vision and Tweak" to Vision and Change

Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website

Introducing Immunology Research Literature to Understand B-cell Receptor Gene Expression

Your Tax Dollars at Work: A mock grant writing experience centered on scientific process skills

Walkabout: An Easy to Use, Experiential Learning Activity for Applying Abstract Concepts to the Real-World

Learning R for Biologists: A Mini Course Grab-Bag for Instructors

Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms

Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway

It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes

A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding

Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Antibiotic Resistance Genes Detection in Environmental Samples

How to Design a Classroom Activity that Integrates 3D Print Models with Active Learning

Understanding Host-Pathogen Interactions With the Use of Galleria mellonella

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Wikipedia in the Science Classroom

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