CourseSource: Resources

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Generating Biological Hypotheses in a "Course-based Undergraduate Research Experience"(CURE) Course

Hypotheses are often incorrectly defined as educated guesses or if/then statements. Further confusion arises from the fact that not all disciplines define hypotheses similarly. The difficulty in distinguishing between statistical and biological...

Courses: Science Process Skills

scientific methodHPT axisNeural stem cells

Lesson

2929

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362

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0

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Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study

Our interdisciplinary pedagogical case study explores the differences between rural and urban coyotes at the levels of organismal and community ecology. The focus is on how coyotes’ gut microbiomes could affect their behavior via...

Courses: Cell Biology Ecology Ecology Evolution Immunology Introductory Biology Microbiology

dietanimal behaviorimmune systemmicrobiomeNervous systemgut-brain axisImmunoReachdysbiosisCoyoteCytokines

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1250

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182

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Simulating Cortical Rotation, Axis Induction, and Experimental Embryology in Amphibian Embryos Using Clay Models

The study of development requires learners to understand spatially complex concepts like embryo anatomy. Embryo anatomy is dynamic over time, and it is often manipulated by researchers in experiments that are fundamental to the field. This spatial...

Courses: Developmental Biology

developmentXenopusfertilizationEmbryologyinductionSymmetry breakingOrganizerCortical rotationPatterning

Lesson

1452

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155

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The Developmental Origins of Mythology: A Pandemic-Inspired Innovative Developmental Biology Laboratory Exercise

From an experiential, hands-on perspective, the Developmental Biology Laboratory is easily amenable to a wide range of undergraduate-friendly experiments. Thus, pivoting to a virtual laboratory during the COVID-19 pandemic required significant...

Courses: Developmental Biology

gastrulationaxis formationlimb developmentchimeramidline

Lesson

1151

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165

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0

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Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

Homeostasis and negative feedback are crucial, yet difficult, concepts for undergraduates, particularly in the context of the hypothalamo-pituitary axes. This interactive activity was designed to (1) reveal how negative feedback can restore...

Courses: Anatomy-Physiology

cell-cell communicationhomeostasisnegative feedback

Lesson

333

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54

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Using an Interactive Game, Gutsy, to Examine the Impacts of Pathogens and Everyday Events on the Human Gut Microbiome

The human gut microbiome is often associated with ‘good bacteria’ in marketing campaigns for dietary supplements, probiotic drinks, and fermented foods. Yet, the dynamic and complex community of microbes that make up the gut microbiome...

Courses: Anatomy-Physiology Immunology Microbiology

bacteriaGamepathogenhealthmicrobiomediversity

Lesson

7962

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397

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0

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Investigating Cell Signaling with Gene Expression Datasets

Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

Courses: Biochemistry and Molecular Biology Cell Biology

genomicstranscriptionsignaling

Lesson

3140

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502

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Targeting Misconceptions in the Central Dogma by Examining Viral Infection

Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary connections between DNA structure, transcription,...

Courses: Genetics Introductory Biology

datatranscriptionvirustranslationprotein functionmembrane transportPredictions

Lesson

1074

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157

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What do Bone and Silly Putty® have in Common?: A Lesson on Bone Viscoelasticity

Without the use of real-life examples and models, actively instructing and engaging students in complex physiology topics related to bone biomechanics can be challenging. In our large-enrollment Human Physiology & Anatomy courses at the...

Courses: Anatomy-Physiology

structure-functioninjuryAnisotropyHysteresisSkeletal SystemViscoelasticity

Lesson

4239

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408

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0

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Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon

The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon is a common theme in introductory biology,...

Courses: Genetics Introductory Biology Microbiology

prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon

Lesson

5360

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1017

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1

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An active-learning lesson that targets student understanding of population growth in ecology

Effective teaching and learning of population ecology requires integration of quantitative literacy skills. To facilitate student learning in population ecology and provide students with the opportunity to develop and apply quantitative skills, we...

Courses: Ecology Ecology Introductory Biology

population growthexponential growthlogistic growthpopulation ecologygrowth rateDensityAbundancecarrying capacitylinear growth

Lesson

4296

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1460

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Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration

One key to student success in introductory and cell biology courses is a foundational knowledge of cellular respiration. This is a content area in which students often harbor misconceptions that make cellular respiration particularly challenging...

Courses: Biochemistry and Molecular Biology Cell Biology Introductory Biology

data analysisCellular RespirationElectron Transport ChainEnergy transformationsMitochondriaOxidative phosphorylationWeight loss drugs24-dinitrophenol (DNP)

Lesson

2115

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397

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0

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Integrating Manipulatives and Animations to Visualize Holliday Junctions

The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...

Courses: Biochemistry and Molecular Biology Genetics

dna structureDNA damageDNA recombinationGene crossoverHolliday junction

Lesson

1708

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352

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0

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Chilling in the Cold: Using Thermal Acclimation to Demonstrate Phenotypic Plasticity in Animals

The lesson plan described here provides students hands-on, scientific experiences that relate to the globally important issue of climate change and its impacts on animals. Students use the scientific method and basic components of experimental...

Courses: Ecology Ecology Evolution Science Process Skills

scientific methodclimate changephenotypic plasticityfruit fliesaccclimationcold tolerancethink-pair-share

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1598

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344

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Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

Courses: Biochemistry and Molecular Biology Cell Biology Developmental Biology Science Process Skills

developmenttranscriptiongene expressionmodel organismembryo

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278

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Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon

The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness of components within a biological process and...

Courses: Introductory Biology

prokaryotesgene regulationLac Operoninducible operon

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1669

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314

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Understanding Host-Pathogen Interactions With the Use of Galleria mellonella

The Galleria mellonella; the larvae of the Greater Wax Moth, is a safe and effective means to study host-pathogen interactions in the undergraduate setting. The use of animal models in the teaching classroom provides an opportunity to discuss...

Courses: Immunology Microbiology

innate immunitybacterial pathogenesisHost-pathogen interactionsGalleria mellonellaVirulence

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189

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3

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Exploring Biological Variation and the Value of Natural History Collections Using an Online Lesson

First-year science students in large-enrollment lecture courses are rarely given opportunities to contribute to science beyond their classroom as part of their curriculum. Meanwhile, natural history museums are eager to engage students and the...

Courses: Introductory Biology

natural historymuseumBiodiversityalgaeherbariumseaweedcitzen science

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463

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42

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Space Mission Ecology: Making Connections Among Science Disciplines Through the Lens of a Unique Plant

With this case study, we aim to increase awareness of essential services plants provide to society, as well as the importance of fundamental aspects of ecology for other disciplines and the interconnectedness among different fields of science in...

Courses: Ecology Ecology Introductory Biology Plant Biology Science Process Skills

ecologycollaborationplant biologyScience CommunicationBioregenerative Life SupportInterdisciplinary Connections

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2000

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176

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Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism

Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...

Courses: Biochemistry and Molecular Biology Introductory Biology Science Process Skills

exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity

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Generating Biological Hypotheses in a "Course-based Undergraduate Research Experience"(CURE) Course

Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study

Simulating Cortical Rotation, Axis Induction, and Experimental Embryology in Amphibian Embryos Using Clay Models

The Developmental Origins of Mythology: A Pandemic-Inspired Innovative Developmental Biology Laboratory Exercise

Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

Using an Interactive Game, Gutsy, to Examine the Impacts of Pathogens and Everyday Events on the Human Gut Microbiome

Investigating Cell Signaling with Gene Expression Datasets

Targeting Misconceptions in the Central Dogma by Examining Viral Infection

What do Bone and Silly Putty® have in Common?: A Lesson on Bone Viscoelasticity

Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon

An active-learning lesson that targets student understanding of population growth in ecology

Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration

Integrating Manipulatives and Animations to Visualize Holliday Junctions

Chilling in the Cold: Using Thermal Acclimation to Demonstrate Phenotypic Plasticity in Animals

Investigating Gene Expression and Cell Specialization in Axolotl Embryos

Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon

Understanding Host-Pathogen Interactions With the Use of Galleria mellonella

Exploring Biological Variation and the Value of Natural History Collections Using an Online Lesson

Space Mission Ecology: Making Connections Among Science Disciplines Through the Lens of a Unique Plant

Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism

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