CourseSource: Resources

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by characterizing...

Courses: Genetics Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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2563

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641

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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway

Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions. This laboratory lesson helps students to understand the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Microbiology Science Process Skills

SelectionyeastMetabolismcysteinemediamethioninemutantPathwaysulfur

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3352

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275

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Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience tailored for junior and senior undergraduate biology...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Microbiology

EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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1653

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245

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Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners

Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

Courses: Developmental Biology Genetics

mathematical modelhomologous recombinationCre/loxgene targeting

Teaching Tools and Strategies

1162

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346

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Fostering Student to Student Collaboration Across Institutions in a Protein Centric CURE

Collaboration is an essential component of research because it allows scientists to share expertise and tackle difficult scientific questions. While many undergraduate science courses include inquiry-based or authentic research projects,...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Professional Development and Career Planning Science Process Skills

communicationBiochemistrycollaborationCUREhypothesisStudent to StudentInter institutionalProtein CentricAssignments

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1194

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139

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Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection

In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection to cancer treatment. In this lesson, students...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics

cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

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3146

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897

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1

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Fruit Fly Genetics in a Day: A Guided Exploration to Help Many Large Sections of Beginning Students Uncover the Secrets of Sex-linked Inheritance

Moving beyond the basic concepts of autosomal Mendelian inheritance to sex-linkage can be difficult for introductory biology students. Although crosses with Drosophila fruit flies have long been a mainstay of genetics units that teach these...

Courses: Genetics

Mendelian Geneticsfruit fly biologysex-linked inheritance

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6537

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1121

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Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Science Process Skills

geneticsbioinformaticsdrosophilachi-square analysiscomplementation mappingmode of inheritancethree-point mapping

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4197

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668

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Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory

Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab technique utilized within immunology and molecular...

Courses: Immunology

Immunologyexperimental designFlow cytometryMice

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1885

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350

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Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website

Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted toxicities. PharmGKB is an online pharmacogenomics...

Courses: Genetics Toxicology

toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

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1734

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422

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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5715

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979

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A clicker-based case study that untangles student thinking about the processes in the central dogma

The central dogma of biology is a foundational concept that provides a scaffold to understand how genetic information flows in biological systems. Despite its importance, undergraduate students often poorly understand central dogma processes (DNA...

Courses: Genetics Introductory Biology

mutationtranscriptionphenotypecentral dogmatranslationDNA replication

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1399

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395

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Where Does Elsie's Hair Color Come From? A "De-Simplified" Pedigree Lesson

Pedigree analysis is part of most Genetics curricula, but the examples traditionally used in genetics courses present phenotypes as if they were entirely and inexorably defined by genotype. This does not reflect the current state of understanding...

Courses: Genetics Introductory Biology