CourseSource: Resources

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Teaching Cell Structures through Games

As the basic unit of life, cells are a foundational concept for all of biology. Before students can appreciate how eukaryotic cells function either in isolation or in higher order and multicellular organisms, they must first have a basic...

Courses: Introductory Biology

Cell Structurecell organellesTransmembrane Transport

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3776

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415

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0

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Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformaticsmolecular modelingCOVID19protein structure and functionUCSF ChimeraSARS-CoV-2 spike proteinACE2 receptor

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5292

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693

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0

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Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

Courses: Biochemistry and Molecular Biology Introductory Biology

structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

Lesson

3384

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1353

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Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function

As instructors of introductory biology courses for majors and non-majors, we have struggled with teaching the concept of cell structure and function in an engaging way. However, this is a foundational concept that most biology instructors...

Courses: Cell Biology Introductory Biology Science Process Skills

cell functionCell StructureCellular diversityDynamic cellular functionOrganelle function

Lesson

4908

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495

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0

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Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Science Process Skills

modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

Lesson

1730

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422

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0

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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2115

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396

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0

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Integrating Manipulatives and Animations to Visualize Holliday Junctions

The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...

Courses: Biochemistry and Molecular Biology Genetics

dna structureDNA damageDNA recombinationGene crossoverHolliday junction

Lesson

1191

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138

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Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection

In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection to cancer treatment. In this lesson, students...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics

cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

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2463

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743

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Green Design: How do Leaf Structures Optimize Photosynthesis and Promote Survival?

One of the major learning objectives established by the American Society of Plant Biologists and the Botanical Society of America has students answer the question: How do plant structures enable life functions? This lesson helps students answer...

Courses: Introductory Biology Plant Biology

photosynthesisepidermal layerleaf anatomymesophyllpalisade parenchymaplant anatomyplant structure functionspongy parenchymaStomata

Teaching Tools and Strategies

2544

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211

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An Interactive Protocol for In-Classroom DNA Extraction

Using commonly available materials, this tool allows students to extract DNA, exploring DNA chemistry and the principles of experimental design and execution. We take a “Choose Your Own Adventure” approach encouraging students to...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

geneticsDNAbiochemical structure and function

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2815

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681

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The Case of the Missing Strawberries: RFLP analysis

While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory exercises related to molecular genotyping by...

Courses: Genetics Science Process Skills

process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP

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2159

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469

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Teaching students to read, interpret, and write about scientific research: A press release assignment in a large, lower-division class

A central skill in any science discipline is the ability to read, understand, and discuss the primary literature of the discipline. However, teaching this skill presents unique challenges within large, lower-division courses. To assess our...

Courses: Cell Biology Science Process Skills

cell biologyScience Communicationscientific literacyGraduate Teaching Assistant Professional DevelopmentBiological LiteracyPrimary ResearchWriting Skills

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2050

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517

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0

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A Simple Method for Predicting a Molecule's Biological Properties From Its Polarity

The distinction between very polar and less polar substances is a foundation of biochemistry, cell biology, and physiology; it surfaces in multiple concept inventories and elaborations of biological core concepts. However, in our experience, most...

Courses: Anatomy-Physiology Biochemistry and Molecular Biology Cell Biology Introductory Biology

Diffusionsolubilitycovalent bondshydrophilichydrophobicpartition coefficientplasma membranepolarity

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2982

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349

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Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding

This lesson introduces beginning biochemistry students to the concept of a biomolecule binding site, such as a neurotransmitter receptor site or an enzyme active site. A simple organic molecule, the neurotransmitter serotonin, is the focus of the...

Courses: Biochemistry and Molecular Biology

active sitebindingbinding sitehydrogen bondinghydrophobic effectionic interactionsnon-covalent forces

Teaching Tools and Strategies

2003

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331

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0

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"Reading groups" in an undergraduate biology course: A peer-based model to help students develop skills to evaluate primary literature

Undergraduates who learn to evaluate primary literature demonstrate an enhanced ability to understand the process of science, weigh scientific evidence, and think critically (e.g. 6,8). Studies show that students who learn how to dissect primary...

Courses: Biochemistry and Molecular Biology Science Process Skills

primary literaturecritical thinkingSelf-EfficacyDiscussionPeer-based Learning

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3406

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285

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Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype

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Meiosis: A Play in Three Acts, Starring DNA Sequence

Meiosis is well known for being a sticky topic that appears repeatedly in biology curricula. We observe that a typical undergraduate biology major cannot correctly identify haploid and diploid cells or explain how and why chromosomes pair before...

Courses: Cell Biology Genetics Introductory Biology

recombinationmeiosisDNA sequenceCrossingoverchromosome structureHolliday junctionhomology

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346

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A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is more challenging to illustrate complex genetic...

Courses: Developmental Biology Genetics

mutationProtein Structureethicscentral dogmahuman disease

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1793

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342

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Cutthroat trout in Colorado: A case study connecting evolution and conservation

Evaluation of evidence is a key process skill for the core competencies of applying the process of science and using quantitative reasoning. This case study enables upper-division biology students to practice these skills by applying evolutionary...

Courses: Evolution Genetics Science Process Skills

population geneticsphylogeneticsSpeciationdivergencegene flow

Lesson

1647

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244

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Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners

Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

Courses: Developmental Biology Genetics

mathematical modelhomologous recombinationCre/loxgene targeting

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Teaching Cell Structures through Games

Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function

Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

How to Find a Gene: Retrieving Information From Gene Databases

Integrating Manipulatives and Animations to Visualize Holliday Junctions

Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection

Green Design: How do Leaf Structures Optimize Photosynthesis and Promote Survival?

An Interactive Protocol for In-Classroom DNA Extraction

The Case of the Missing Strawberries: RFLP analysis

Teaching students to read, interpret, and write about scientific research: A press release assignment in a large, lower-division class

A Simple Method for Predicting a Molecule's Biological Properties From Its Polarity

Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding

"Reading groups" in an undergraduate biology course: A peer-based model to help students develop skills to evaluate primary literature

Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

Meiosis: A Play in Three Acts, Starring DNA Sequence

A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Cutthroat trout in Colorado: A case study connecting evolution and conservation

Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners

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