CourseSource: Resources

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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway

Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions. This laboratory lesson helps students to understand the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Microbiology Science Process Skills

SelectionyeastMetabolismcysteinemediamethioninemutantPathwaysulfur

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1938

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327

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Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Many video resources exist to teach Mendelian genetics, but most consist of passive delivery of information rather than active construction of knowledge by users. We have created two interactive video vignettes (IVVs) that can be used together or...

Courses: Genetics Introductory Biology Science Process Skills

genotypephenotypeallelespedigreedominanceHardy-Weinberg equilibriumInheritance

Teaching Tools and Strategies

1072

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138

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An Open Source, Collaborative Electronic Notebook for Undergraduate Laboratory Classes

To overcome many of the limitations of the paper laboratory notebook (PLN), we developed an electronic laboratory notebook (e-LN) for the Dynamic Genome course at the University of California. The Dynamic Genome course is an authentic research...

Courses: Science Process Skills

data collectionData annotationNotebook Skills

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4496

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1314

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Dilution and Pipetting Lesson Using Food Dyes

In this lesson students learn how to use micropipettors to accurately measure small volumes of liquids and perform dilutions using food dyes. Students dilute four food dyes at 10X concentration to 1X working stocks. Using the formula c1v1=c2v2...

Courses: Science Process Skills

dilutionCalculationLab SkillsMicropipetting

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818

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169

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The Comics Project: Synthesizing and Communicating Science with Comics

Students, especially non-science majors, often see science as abstracted from their daily lives. Moreover, students often struggle to translate scientific concepts into everyday language in order to communicate to their communities what they have...

Courses: Introductory Biology Science Process Skills

communicating scienceScience & Societycomics

Teaching Tools and Strategies

1041

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194

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Wikipedia in the Science Classroom

Despite research suggesting that writing-to-learn exercises (WTL) in the classroom are associated with increased student learning, WTL is still not widely implemented in science courses. To provide our students with a meaningful WTL exercise that...

Courses: Introductory Biology Science Process Skills

scientific writingcritical evaluationWikipediawriting for general public

Teaching Tools and Strategies

673

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93

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A "How-to" Guide For Producing Recorded Interviews

Now that almost every student carries a camera in their pocket, student-created digital media items can be used to supplement curriculum material and as assessment. Although students can easily record interviews, events, and activities on their...

Courses: Introductory Biology

communicationemployabilitygathering data

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3103

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443

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Small Organisms with Big Consequences: Understanding the Microbial World Around Us

Creating a hands-on lab that conveys important information while simultaneously allowing for student autonomy can be difficult. This is particularly true for the field of microbiology, in which labs often rely on “recipe-style”...

Courses: Introductory Biology Microbiology Science Process Skills

disease transmissionmicrobiologymicrobiomeliterature reviewPeer reviewPathogensHealth and WellnessThe Scientific Method

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1227

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281

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Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix

The extracellular matrix (ECM) provides structural support to cells, but also has key roles in mediating cell adhesion, cell signaling, and differentiation. While this topic is discussed in the lecture setting, it is not heavily studied in...

Courses: Cell Biology Neurobiology

Neural extracellular matrixPerineuronal netPrimary neuronal culture

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1556

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210

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Building student literacy and metacognition through reading science in the news

Ensuring students' science literacy is essential for preparation for study in science disciplines and is of critical importance given contemporary challenges in determining the legitimacy and accuracy of science in popular media. This lesson...

Courses: Introductory Biology

metacognitionStem cellsscience literacycloninggenetically modified organismshuman genetic diseasescience news

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3440

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3004

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Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy disciplines such as molecular biology, where emphasis...

Courses: Biochemistry and Molecular Biology

experimental designcrisprmolecular technique

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2300

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460

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Translating Co-Translational Translocation

Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also determines the resulting protein topology, is a complex...

Courses: Cell Biology

Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

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4744

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450

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The Avocado Lab: An Inquiry-Driven Exploration of an Enzymatic Browning Reaction

Typical biochemistry labs exploring basic enzyme activity rely on costly, time-consuming protein purification and rarely explore enzyme function in situ. Further, complex purification procedures leave little room for novelty in experimental...

Courses: Biochemistry and Molecular Biology Introductory Biology

enzymescontrolsenzyme inhibition

Teaching Tools and Strategies

1285

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Integrating Primary Literature in a Lecture Course Using a Modified Version of the C.R.E.A.T.E. Approach

Reforms in undergraduate science education place an increasing emphasis on teaching the skills of practicing scientists, such as reading and interpreting the primary research literature. Many approaches have been proposed to introduce students to...

Courses: Ecology Ecology

primary literatureDiscussionModified JigsawPeer-based Learning

Essay

817

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196

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Thinking deeply about quantitative analysis: Building a Biologist's Toolkit

Vision and Change in Undergraduate Biology Education encouraged faculty to focus on core concepts and competencies in undergraduate curriculum. We created a sophomore-level course, Biologists' Toolkit, to focus on the competencies of...

Courses: Introductory Biology

Vision and ChangeRRStudioquantitative literacystatistical analysisScientific communication

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955

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BioMap Degree Plan: A project to guide students in exploring, defining, and building a plan to achieve career goals

Traditional college students begin their academic journey with a variety of ideas about the careers they might ultimately pursue. Some students have always known what they want to do, some have ideas about possible careers, while others have never...

Courses: Introductory Biology Professional Development and Career Planning

Career ExplorationCo-curricularsDegree Planning

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2811

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491

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GMC: Genes, Mutations and Cancer - Group Concept Map Development

It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the classroom to explore the relationship between...

Courses: Cell Biology Genetics Introductory Biology

mutationcancerCell Division

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism

Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...

Courses: Biochemistry and Molecular Biology Introductory Biology Science Process Skills

exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity

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A CURE for Salmonella: A Laboratory Course in Pathogen Microbiology and Genomics

Rapid advances in genomics and bioinformatics, the vast amount of data generated by next-generation sequencing, and the penetration of the ‘-omics’ into many areas of biology have created a need for students with hands-on experience with...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Microbiology