CourseSource: Resources

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

Courses: Genetics Introductory Biology Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

Lesson

1731

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422

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

Lesson

3089

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738

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0

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by characterizing...

Courses: Genetics Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

Lesson

3140

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502

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Targeting Misconceptions in the Central Dogma by Examining Viral Infection

Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary connections between DNA structure, transcription,...

Courses: Genetics Introductory Biology

datatranscriptionvirustranslationprotein functionmembrane transportPredictions

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541

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81

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0

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Using Raw Sequence Data to Analyze Tumor Suppressor Mutations

Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to map DNA sequence variants to functional regions...

Courses: Bioinformatics Genetics

bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

Lesson

2590

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204

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A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed a laboratory module to provide a guided research...

Courses: Bioinformatics Cell Biology Developmental Biology Genetics Science Process Skills

microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

Lesson

2993

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346

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A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is more challenging to illustrate complex genetic...

Courses: Developmental Biology Genetics

mutationProtein Structureethicscentral dogmahuman disease

Lesson

1598

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344

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Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

Courses: Biochemistry and Molecular Biology Cell Biology Developmental Biology Science Process Skills

developmenttranscriptiongene expressionmodel organismembryo

Lesson

3653

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3319

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Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy disciplines such as molecular biology, where emphasis...

Courses: Biochemistry and Molecular Biology

experimental designcrisprmolecular technique

Teaching Tools and Strategies

2184

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356

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DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.

Advances in high-throughput techniques have resulted in a rising demand for scientists with basic bioinformatics skills as well as workshops and curricula that teach students bioinformatics concepts. DNA Detective is a workshop we designed to...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Plant Biology

geneticsbioinformaticsDNAgenotypephenotypegenegene annotation

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1578

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350

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0

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Understanding Protein Domains: A Modular Approach

An understanding of protein structure, function, and interaction is central to biochemistry. One angle into this topic is to engage students in considering protein domains as modules that develop form and execute function semi-independently. Here,...

Courses: Biochemistry and Molecular Biology Cell Biology Science Process Skills

Protein Structure

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7669

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1462

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics

bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

Science Behind the Lesson

1483

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202

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The Science Behind the ACTN3 Polymorphism

A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2)...

Courses: Anatomy-Physiology Genetics

protein structure and functionhuman genetic variationskeletal muscle physiology

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2285

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278

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1

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Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon

The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness of components within a biological process and...

Courses: Introductory Biology

prokaryotesgene regulationLac Operoninducible operon

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3037

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207

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The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation

This active learning exercise introduces students to the plant microbiome and the contributions that bacteria make to plant growth and food production. The Three Sisters are an ancient indigenous practice in which three plant crops and the...

Courses: Microbiology

SymbiosisPlant microbiomeNitrogen fixationNutritional content of foodElectron flowSociety impact of microorganisms

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4109

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596

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics Introductory Biology

gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

Lesson

3406

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285

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Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype

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4239

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408

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Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon

The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon is a common theme in introductory biology,...

Courses: Genetics Introductory Biology Microbiology

prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon

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7962

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397

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Investigating Cell Signaling with Gene Expression Datasets

Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

Courses: Biochemistry and Molecular Biology Cell Biology

genomicstranscriptionsignaling

Lesson

5559

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2662

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Cell Signaling Pathways - a Case Study Approach

Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

Courses: Cell Biology Developmental Biology

signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

How to Find a Gene: Retrieving Information From Gene Databases

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Targeting Misconceptions in the Central Dogma by Examining Viral Infection

Using Raw Sequence Data to Analyze Tumor Suppressor Mutations

A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Investigating Gene Expression and Cell Specialization in Axolotl Embryos

Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.

Understanding Protein Domains: A Modular Approach

An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

The Science Behind the ACTN3 Polymorphism

Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon

The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation

Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon

Investigating Cell Signaling with Gene Expression Datasets

Cell Signaling Pathways - a Case Study Approach

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