CourseSource: Resources

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Where Does Elsie's Hair Color Come From? A "De-Simplified" Pedigree Lesson

Pedigree analysis is part of most Genetics curricula, but the examples traditionally used in genetics courses present phenotypes as if they were entirely and inexorably defined by genotype. This does not reflect the current state of understanding...

Courses: Genetics Introductory Biology

pedigreeMultifactorialphenotypic variationpenetranceexpressivityquantitative variation

Essay

832

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126

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Implementing active learning approaches into an upper-division biology course

In this essay, we present our strategy for implementing active learning strategies into an upper division course on Human Genetics. Our principal goal was to shift from a traditional didactic course design, to one that more clearly placed the...

Courses: Genetics Introductory Biology

human biologyPedigree analysisRare genetic diseases

Lesson

2029

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357

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1

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Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Many video resources exist to teach Mendelian genetics, but most consist of passive delivery of information rather than active construction of knowledge by users. We have created two interactive video vignettes (IVVs) that can be used together or...

Courses: Genetics Introductory Biology Science Process Skills

genotypephenotypeallelespedigreedominanceHardy-Weinberg equilibriumInheritance

Lesson

3763

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285

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Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome

This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

Courses: Biochemistry and Molecular Biology Genetics

gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

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3162

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404

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Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples

Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the environment, and gene-by-environment interactions...

Courses: Evolution Genetics Introductory Biology

genesenvironmentMendelQuantitative traitsMultifactorialGene by environment interactions

Lesson

1658

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223

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Building student literacy and metacognition through reading science in the news

Ensuring students' science literacy is essential for preparation for study in science disciplines and is of critical importance given contemporary challenges in determining the legitimacy and accuracy of science in popular media. This lesson...

Courses: Introductory Biology

metacognitionStem cellsscience literacycloninggenetically modified organismshuman genetic diseasescience news

Lesson

4206

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286

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Analysis of Microbiomes Using Free Web-Based Tools in Online and In-Person Undergraduate Science Courses

Our understanding of microbiomes, or the collection of microorganisms and their genes in a given environment, has been revolutionized by technological and computational advances. However, many undergraduate students do not get hands-on experiences...

Courses: Bioinformatics Ecology Ecology Microbiology

microbiomeDNA SubwayCyVerseCourse based undergraduate researchQIIME2ranacapa

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2995

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549

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A Fun Introductory Command Line Lesson: Next Generation Sequencing Quality Analysis with Emoji!

Radical innovations in DNA sequencing technology over the past decade have created an increased need for computational bioinformatics analyses in the 21st century STEM workforce. Recent evidence however demonstrates that there are significant...

Courses: Bioinformatics

bioinformaticsgenomicscodingJupyter notebookcommand lineCyVersescriptingnext generation sequencing analysis

Lesson

3791

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1247

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My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)

Essay

923

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202

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Thinking deeply about quantitative analysis: Building a Biologist's Toolkit

Vision and Change in Undergraduate Biology Education encouraged faculty to focus on core concepts and competencies in undergraduate curriculum. We created a sophomore-level course, Biologists' Toolkit, to focus on the competencies of...

Courses: Introductory Biology

Vision and ChangeRRStudioquantitative literacystatistical analysisScientific communication

Lesson

7970

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397

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Investigating Cell Signaling with Gene Expression Datasets

Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

Courses: Biochemistry and Molecular Biology Cell Biology

genomicstranscriptionsignaling

Teaching Tools and Strategies

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A 360˚ View of COVID-19

In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Immunology Introductory Biology Microbiology Science Process Skills

geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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Assessing Urban Biodiversity With the eBird Citizen Science Project: A Course-Based Undergraduate Research Experience (CURE) Module

The eBird citizen science module takes advantage of technology tools and online resources developed by the Cornell Laboratory of Ornithology (http://ebird.org) to achieve several learning objectives embedded in a semester-long upper-level biology...

Courses: Ecology Ecology Science Process Skills

datacitizen sciencecommunityBiodiversitySpecieshypothesishabitat

Lesson

3885

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209

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Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab

Structure and function are correlated at all levels of biology. This topic is typically addressed early in an undergraduate class in general or molecular biology before students have gained much skill or knowledge in molecular biology. However, an...

Courses: Biochemistry and Molecular Biology Introductory Biology

Protein StructureproteaseEnzymechemical bondscatalysissolubility

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Integrating Community Ecology Into the Study of Parasites: Exploring the Effect of Host Behavior on Parasite Transmission Rates

Organismal life cycles are often presented as a set of facts to memorize in undergraduate biology courses. This approach is cognitively demanding for students and fails to convey how central life cycle diversity is in shaping ecological and...

Courses: Ecology Ecology Science Process Skills

statisticsspecies interactionsQuantitative reasoninggraphsCommunity EcologyParasitologyfood webs

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Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformaticsmolecular modelingCOVID19protein structure and functionUCSF ChimeraSARS-CoV-2 spike proteinACE2 receptor

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A virtual laboratory on cell division using a publicly-available image database

Cell division is a key concept in cell biology. While there are many popular activities to teach students the stages of mitosis, most make use of simple schematics, cartoons, or textbook diagrams. Others engage students in acting out the stages,...

Courses: Cell Biology Science Process Skills

image analysismicroscopymitosisCellular Processes

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1566

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301

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Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course

Metagenomics is rapidly evolving due to advances in sequencing technologies and bioinformatics, but without proper training to interpret these datasets, student understanding remains limited. Aimed at undergraduate juniors and seniors and graduate...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Microbiology Science Process Skills

microbiome

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1007

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Building Trees: Introducing evolutionary concepts by exploring Crassulaceae phylogeny and biogeography

Teaching evolutionary theory is foundational for all biological sciences and a key aspect of overall science literacy. The conceptual framework for understanding evolution relies on thinking clearly about evolutionary trees (phylogenetics) and how...

Courses: Evolution Introductory Biology

EvolutionphylogeneticsTree thinkingbiogeography

Lesson

1067

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168

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Outside the Norm: Using Public Ecology Database Information to Teach Biostatistics

Biology students’ understanding of statistics is incomplete due to poor integration of these two disciplines. In some cases, students fail to learn statistics at the undergraduate level due to poor student interest and cursory teaching of...

Courses: Ecology Ecology Introductory Biology Science Process Skills

biostatisticshypothesis testingexperimental design

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Where Does Elsie's Hair Color Come From? A "De-Simplified" Pedigree Lesson

Implementing active learning approaches into an upper-division biology course

Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome

Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples

Building student literacy and metacognition through reading science in the news

Analysis of Microbiomes Using Free Web-Based Tools in Online and In-Person Undergraduate Science Courses

A Fun Introductory Command Line Lesson: Next Generation Sequencing Quality Analysis with Emoji!

My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

Thinking deeply about quantitative analysis: Building a Biologist's Toolkit

Investigating Cell Signaling with Gene Expression Datasets

A 360˚ View of COVID-19

Assessing Urban Biodiversity With the eBird Citizen Science Project: A Course-Based Undergraduate Research Experience (CURE) Module

Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab

Integrating Community Ecology Into the Study of Parasites: Exploring the Effect of Host Behavior on Parasite Transmission Rates

Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

A virtual laboratory on cell division using a publicly-available image database

Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course

Building Trees: Introducing evolutionary concepts by exploring Crassulaceae phylogeny and biogeography

Outside the Norm: Using Public Ecology Database Information to Teach Biostatistics

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