CourseSource: Resources

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Using Raw Sequence Data to Analyze Tumor Suppressor Mutations

Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to map DNA sequence variants to functional regions...

Courses: Bioinformatics Genetics

bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

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2279

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277

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Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon

The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness of components within a biological process and...

Courses: Introductory Biology

prokaryotesgene regulationLac Operoninducible operon

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4235

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408

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Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon

The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon is a common theme in introductory biology,...

Courses: Genetics Introductory Biology Microbiology

prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon

Lesson

3355

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1180

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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3157

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404

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Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples

Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the environment, and gene-by-environment interactions...

Courses: Evolution Genetics Introductory Biology

genesenvironmentMendelQuantitative traitsMultifactorialGene by environment interactions

Lesson

3781

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1245

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My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)

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7666

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1462

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics

bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

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1191

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137

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Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection

In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection to cancer treatment. In this lesson, students...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics

cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

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3090

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356

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Discovering Cellular Respiration with Computational Modeling and Simulations

Cellular respiration, a common topic among introductory and cellular biology curricula, is a complex biological process that exemplifies core biological concepts, including systems, pathways and transformation of energy, and structure and function...

Courses: Introductory Biology

Cellular MechanismsCellular RespirationFermentation

Lesson

3502

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1299

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A CRISPR/Cas Guide RNA Design In Silico Activity

CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics

bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico

Lesson

3355

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269

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Pesticides in My Smoothie Bowl?

Teaching resources, especially active learning pedagogy, are scarce for toxicology compared to what is available for other disciplines. Ecological and human health risk assessment are important aspects of toxicology and are routinely used by...

Courses: Toxicology

data analysistoxicologychemical toxicityecological risk assessmenthuman risk assessmentpesticide

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1218

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556

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Understanding Gastric Acid Secretion: An Active Learning Approach

The human digestive system is a diverse network of cells, tissues, and organs that is regulated by systemic (e.g., nervous and endocrine systems) and local factors (e.g., secretions, pH, and the microbiome). Given the volume of content and the...

Courses: Anatomy-Physiology

diseasesignal transductionAcid SecretionAutonomic Nervous SystemEndocrineGastric PhysiologyGPCRHistology of Gastric Pit

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2889

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505

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GMC: Genes, Mutations and Cancer - Group Concept Map Development

It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the classroom to explore the relationship between...

Courses: Cell Biology Genetics Introductory Biology

mutationcancerCell Division

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3493

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767

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"Got Algae?" A Sorting Game for Introducing the Weird and Wonderful Diversity of Algae

Algae are a fascinating and diverse organismal group, with global ecological importance, a storied evolutionary history and deep connections to both contemporary and historical human societies. Yet non-experts who teach algal diversity face a lack...

Courses: Ecology Ecology Evolution Plant Biology

phylogenyBiodiversityphotosynthesisalgaeseaweedmonophyly

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1258

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92

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Gender and Classroom Participation: A Case for Quantitative Analysis

Teaching statistics to students using authentic research is one way to highlight the transferability and value of the material taught in the class. Below we describe an activity in Statistics for Biological and Health Sciences (STAT2510), an...

Courses: Science Process Skills

statisticsgenderpopulationProportionSampleEquality

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1391

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233

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Designing an Asynchronous, Self-Led Aquatic Ecology Field Trip

Due to the COVID-19 pandemic and increasing need to teach students online, aquatic scientists are looking for ways to give students field experiences virtually. Asynchronous, self-led field trips are emerging as a solution. However, due to the...

Courses: Ecology Ecology

observationecosystem structureexploration

Lesson

2388

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279

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Escape Zoom!: Reviewing Introductory Evolution Content Using an Escape Room Format

Reviewing and integrating key concepts and learning goals at the end of a biology course can be overwhelming to students and instructors alike. Often end-of-term review sessions in preparation for final exams are heavily based on memorization, and...

Courses: Ecology Ecology Evolution Genetics

Evolutionartificial selectionSpeciationextinctionsexual selectionphylogenetic treesmechanisms of evolution

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4804

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Teaching Cancer Biology Through a Lens of Social Justice

The biology classroom is not separate from the greater context of society; social issues can and should be presented in connection with the content. Here we present an example of antiracist teaching using the molecular/cellular biology of cancer...

Courses: Cell Biology

assessmentcancersocial justicePOGILAlignmentPublic ExamPublic

Lesson

1772

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130

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Snail Races: An Inquiry-Based Approach to Learn Invasive Species Ecology

Inquiry-based lessons allow learning that is hands-on and student-driven, fostering engagement and retention of knowledge in any discipline. Here, we use this learning framework to engage students in exploring the effects of biotic and abiotic...

Courses: Ecology Ecology

ecologyenvironmentInvasive SpeciesScience CommunicationScientific InquiryDispersal

Lesson

372

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59

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Environmental Injustice: When the Grass is Greener on the Other Side

Environmental pollution is a global threat that is especially prevalent in heavily industrialized and urbanized areas. Pollution can be found in many forms, such as natural and synthetic pollutants from natural and anthropogenic processes. These...

Courses: Ecology Ecology Introductory Biology Science Process Skills Toxicology