CourseSource: Resources

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CURE-all: Large Scale Implementation of Authentic DNA Barcoding Research into First-Year Biology Curriculum

Growing calls in science education reform have emphasized wide-scale engagement of first-year undergraduate students in authentic research experiences; however, large course enrollments, inadequate student experience, limited resources and...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Evolution Genetics Introductory Biology Science Process Skills

phylogeneticsbioinformaticsBiodiversityprocess of sciencetaxonomyPCRDNADNA sequencegel electrophoresis

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3802

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1249

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My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)

Teaching Tools and Strategies

5129

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459

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Drawing flowcharts of lab protocols helps students prepare for biology labs

With the publishing of the Vision and Change report, we know it is best practice to include authentic research experiences in our undergraduate science lab classes. One big challenge in teaching so-called "wet lab" classes is figuring...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Science Process Skills

laboratorymolecular biologyUndergraduateprotocolflowchart

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1552

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767

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Data Analysis Recitation Activities Support Better Understanding in SEA-PHAGES CURE

Course-based undergraduate research experiences (CUREs) are widely known to improve student learning outcomes in the sciences. Undergraduate students have a particularly difficult time interpreting the scientific data that they generate in these...

Courses: Science Process Skills

bacteriophageDNA extractionGel analysisPhage purificationTiter calculationViral replicative growth

Lesson

3393

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1183

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0

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

Teaching Tools and Strategies

1145

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142

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An Open Source, Collaborative Electronic Notebook for Undergraduate Laboratory Classes

To overcome many of the limitations of the paper laboratory notebook (PLN), we developed an electronic laboratory notebook (e-LN) for the Dynamic Genome course at the University of California. The Dynamic Genome course is an authentic research...

Courses: Science Process Skills

data collectionData annotationNotebook Skills

Lesson

3706

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3401

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Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy disciplines such as molecular biology, where emphasis...

Courses: Biochemistry and Molecular Biology

experimental designcrisprmolecular technique

Lesson

3374

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280

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Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience tailored for junior and senior undergraduate biology...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Microbiology

EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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1908

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644

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A Close-Up Look at PCR

The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate students often have poor comprehension about the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Science Process Skills

PCRDNA replication

Lesson

5681

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1171

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3

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Meiosis: A Play in Three Acts, Starring DNA Sequence

Meiosis is well known for being a sticky topic that appears repeatedly in biology curricula. We observe that a typical undergraduate biology major cannot correctly identify haploid and diploid cells or explain how and why chromosomes pair before...

Courses: Cell Biology Genetics Introductory Biology

recombinationmeiosisDNA sequenceCrossingoverchromosome structureHolliday junctionhomology

LessonPlus

1670

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349

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Keep It Shrimple: An Adaptable Student-Driven Research Project for the Introductory Biology Laboratory

A challenge in introductory biology laboratory courses is to provide students with authentic, engaging research opportunities that allow them to take ownership of their experiments. We present a nine-week introductory biology module that allows...

Courses: Introductory Biology Science Process Skills

hypothesis testingexperimental designanimal behaviorbrine shrimp

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4880

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1218

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Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

Courses: Genetics

transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants

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409

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Integrating Manipulatives and Animations to Visualize Holliday Junctions

The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...

Courses: Biochemistry and Molecular Biology Genetics

dna structureDNA damageDNA recombinationGene crossoverHolliday junction

Teaching Tools and Strategies

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308

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Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination

Sanger sequencing is commonly taught with a hands-on approach. Sanger sequencing involves chain termination by dideoxynucleotides, because they are missing the oxygen on the 3’ carbon atom, which is required for the addition of subsequent...

Courses: Genetics

nucleotidessequencingDNAgel electrophoresisChain Termination

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Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism

Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...

Courses: Biochemistry and Molecular Biology Introductory Biology Science Process Skills

exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

Courses: Genetics Introductory Biology Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by characterizing...

Courses: Genetics Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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3356

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618

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

Courses: Bioinformatics Genetics Science Process Skills

mutationcentral dogmatranslationframeshift

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Building Trees: Introducing evolutionary concepts by exploring Crassulaceae phylogeny and biogeography

Teaching evolutionary theory is foundational for all biological sciences and a key aspect of overall science literacy. The conceptual framework for understanding evolution relies on thinking clearly about evolutionary trees (phylogenetics) and how...

Courses: Evolution Introductory Biology

EvolutionphylogeneticsTree thinkingbiogeography

Lesson

2445

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168

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A Rapid Genetic Screen Using Wisconsin Fast Plants^®: A Hands-On Approach to Inheritance of de novo Mutations

Some concepts in genetics, such as genetic screens, are complex for students to visualize in a classroom and can be cumbersome to undertake in the laboratory. Typically, very large populations are needed, which can be addressed by using...

Courses: Genetics Plant Biology

mutationInheritancegermlinesomaplant lifecycle

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CURE-all: Large Scale Implementation of Authentic DNA Barcoding Research into First-Year Biology Curriculum

My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

Drawing flowcharts of lab protocols helps students prepare for biology labs

Data Analysis Recitation Activities Support Better Understanding in SEA-PHAGES CURE

CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

An Open Source, Collaborative Electronic Notebook for Undergraduate Laboratory Classes

Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

A Close-Up Look at PCR

Meiosis: A Play in Three Acts, Starring DNA Sequence

Keep It Shrimple: An Adaptable Student-Driven Research Project for the Introductory Biology Laboratory

Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

Integrating Manipulatives and Animations to Visualize Holliday Junctions

Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination

Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Building Trees: Introducing evolutionary concepts by exploring Crassulaceae phylogeny and biogeography

A Rapid Genetic Screen Using Wisconsin Fast Plants^®: A Hands-On Approach to Inheritance of de novo Mutations

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