CourseSource: Resources

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

Courses: Genetics Introductory Biology Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

Lesson

3097

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739

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0

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by characterizing...

Courses: Genetics Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

Lesson

3393

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1183

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0

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

Lesson

3706

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3401

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Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy disciplines such as molecular biology, where emphasis...

Courses: Biochemistry and Molecular Biology

experimental designcrisprmolecular technique

Lesson

3564

views

264

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0

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SEAS CURE: Exploring Coral Biology Across Scales

Complex biological concepts (like symbiosis and coral biology) that span multiple scales and cross disciplinary boundaries are often difficult for students to understand. This complexity is compounded by the challenges inherent to teaching and...

Courses: Anatomy-Physiology Cell Biology Ecology Ecology Introductory Biology Science Process Skills

microscopyAnatomySymbiosisMetabolismbleachinginvertebratedinoflagellate

Lesson

3802

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1249

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0

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My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)

Teaching Tools and Strategies

5129

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459

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Drawing flowcharts of lab protocols helps students prepare for biology labs

With the publishing of the Vision and Change report, we know it is best practice to include authentic research experiences in our undergraduate science lab classes. One big challenge in teaching so-called "wet lab" classes is figuring...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Science Process Skills

laboratorymolecular biologyUndergraduateprotocolflowchart

Essay

1103

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121

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An Active Textbook Converts "Vision and Tweak" to Vision and Change

Multiple reports over more than a century have documented the problems with the way introductory biology has been taught in most colleges and universities. An influential recent report, Vision and Change in Undergraduate Biology Education, has...

Courses: Introductory Biology

Vision and Changeactive learningintroductory biologyFlipped classroomUndergraduatecore competenciescore conceptsactive textbookcurriculum reform

Lesson

3793

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294

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0

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Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome

This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

Courses: Biochemistry and Molecular Biology Genetics

gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

Lesson

2052

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371

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Drawing “Octo-Pines”: Ice-Breaker Active-Learning Activities to Introduce Drawing-to-Learn in Biology

Drawing has been advocated as a technique to develop visual literacy and observational skills in biology students. To increase student motivation and confidence to draw in our course, we developed an introductory active-learning lesson with a...

Courses: Ecology Ecology Evolution

Zoologydrawingdrawing-to-learnice breaker

Lesson

1610

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345

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0

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Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

Courses: Biochemistry and Molecular Biology Cell Biology Developmental Biology Science Process Skills

developmenttranscriptiongene expressionmodel organismembryo

Lesson

2943

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363

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0

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Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study

Our interdisciplinary pedagogical case study explores the differences between rural and urban coyotes at the levels of organismal and community ecology. The focus is on how coyotes’ gut microbiomes could affect their behavior via...

Courses: Cell Biology Ecology Ecology Evolution Immunology Introductory Biology Microbiology

dietanimal behaviorimmune systemmicrobiomeNervous systemgut-brain axisImmunoReachdysbiosisCoyoteCytokines

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2475

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744

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0

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Green Design: How do Leaf Structures Optimize Photosynthesis and Promote Survival?

One of the major learning objectives established by the American Society of Plant Biologists and the Botanical Society of America has students answer the question: How do plant structures enable life functions? This lesson helps students answer...

Courses: Introductory Biology Plant Biology

photosynthesisepidermal layerleaf anatomymesophyllpalisade parenchymaplant anatomyplant structure functionspongy parenchymaStomata

Teaching Tools and Strategies

1297

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134

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0

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Adaptation and Facilitation of Small Group Activities in an Online Introductory Biology Class

In spring 2020, the sudden mid-semester closure of my campus in response to the global COVID-19 pandemic necessitated a rapid transition to emergency online learning. Consequently, I adapted the small group activities and facilitation methods of...

Courses: Introductory Biology

Cellular communicationNeuronal functionNeuronal structure

Lesson

4341

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1471

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0

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Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration

One key to student success in introductory and cell biology courses is a foundational knowledge of cellular respiration. This is a content area in which students often harbor misconceptions that make cellular respiration particularly challenging...

Courses: Biochemistry and Molecular Biology Cell Biology Introductory Biology

data analysisCellular RespirationElectron Transport ChainEnergy transformationsMitochondriaOxidative phosphorylationWeight loss drugs24-dinitrophenol (DNP)

Lesson

5354

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702

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0

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Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

Courses: Biochemistry and Molecular Biology Introductory Biology

structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

Lesson

2175

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668

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Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the hood." A solid understanding of how a bioinformatics...

Courses: Biochemistry and Molecular Biology Bioinformatics Introductory Biology

BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix

Lesson

4930

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498

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0

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Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Science Process Skills

modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

Lesson

1268

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70

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0

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Defining Life: Exploring Creativity, Scientific Discovery, and Biology Core Concepts in a Disciplinary First-Year Seminar

This unit, Defining Life, engages students in thinking like scientists, applying creativity to science, and learning biology core concepts as they explore the defining characteristics of life. This unit provides an example of a curriculum designed...

Courses: Biochemistry and Molecular Biology Cell Biology Evolution Genetics Introductory Biology Microbiology Science Process Skills

Evolutionbiologycellprocess of science

Lesson

6487

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4120

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CURE-all: Large Scale Implementation of Authentic DNA Barcoding Research into First-Year Biology Curriculum

Growing calls in science education reform have emphasized wide-scale engagement of first-year undergraduate students in authentic research experiences; however, large course enrollments, inadequate student experience, limited resources and...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Evolution Genetics Introductory Biology Science Process Skills

phylogeneticsbioinformaticsBiodiversityprocess of sciencetaxonomyPCRDNADNA sequencegel electrophoresis

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

SEAS CURE: Exploring Coral Biology Across Scales

My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships

Drawing flowcharts of lab protocols helps students prepare for biology labs

An Active Textbook Converts "Vision and Tweak" to Vision and Change

Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome

Drawing “Octo-Pines”: Ice-Breaker Active-Learning Activities to Introduce Drawing-to-Learn in Biology

Investigating Gene Expression and Cell Specialization in Axolotl Embryos

Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study

Green Design: How do Leaf Structures Optimize Photosynthesis and Promote Survival?

Adaptation and Facilitation of Small Group Activities in an Online Introductory Biology Class

Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration

Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Defining Life: Exploring Creativity, Scientific Discovery, and Biology Core Concepts in a Disciplinary First-Year Seminar

CURE-all: Large Scale Implementation of Authentic DNA Barcoding Research into First-Year Biology Curriculum

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