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    3548

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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics

    gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway
    Teaching Tools and Strategies
    2312

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    92

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    How to Design a Classroom Activity that Integrates 3D Print Models with Active Learning
    Student exploration of relevant physical models can deepen knowledge of course material. In this guide we describe a method by which instructors can integrate 3D printing technology with an established teaching strategy, the classroom jigsaw, to...

    Courses: Introductory BiologyIntroductory Biology

    active learning3D print modelsclassroom jigsaw
    Teaching Tools and Strategies
    4795

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    788

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    Science “Fails”: A Bank of Historical Examples for Learning From Failure in Science
    Learning from failure is critically important to the processes of scientific inquiry, discovery, and invention. However, students are not routinely taught how to reflect on, learn from, and ultimately embrace failure, and relatively few curricular...

    Courses: Introductory Physics: Calculus-BasedIntroductory Physics: Calculus-Based Introductory BiologyIntroductory Biology Professional Development and Career PlanningProfessional Development and Career Planning Science Process SkillsScience Process Skills

    metacognitionScience process skillsLearning from failurepower and privilegestudent wellbeing
    Lesson
    2693

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    686

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    Electron Location, Location, Location: Understanding Biological Interactions
    Introductory Biology courses typically introduce the structure and function of biomolecules such as proteins and nucleic acids. To understand biomolecules fully, students require knowledge of fundamental chemistry concepts such as covalent...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    hydrogen bondshydrophobicity/hydrophilicitypolar and non-polar covalent bonds
    Lesson
    1936

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    366

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    Integrating Manipulatives and Animations to Visualize Holliday Junctions
    The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics

    dna structureDNA damageDNA recombinationGene crossoverHolliday junction
    Lesson
    2175

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    438

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    A Short Laboratory Module to Help Infuse Metacognition during an Introductory Course-based Research Experience
    A core competency identified in Vision and Change for undergraduate biology students is the Ability to Apply the Process of Science. Here, we describe a three-week laboratory module for students in an Introductory Cell and Molecular Biology...

    Courses: Science Process SkillsScience Process Skills

    metacognitiongene expressionScientific ProcessExperimenal DesignHypothesis Generationmodel organisms
    Lesson
    5187

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    2571

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    Cell Signaling Pathways - a Case Study Approach
    Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

    Courses: Cell BiologyCell Biology Developmental BiologyDevelopmental Biology

    signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity
    Lesson
    4244

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    702

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    Problem-Based Learning for Physiology: Synthesizing the Cardiovascular System, Respiration, Macronutrient Metabolism, and Renal Function
    Problem Based Learning (PBL) is a valuable tool for helping students overcome reliance on memorization by scaffolding opportunities for them to practice the competency of “systems thinking,” which is the ability to understand...

    Courses: Anatomy-PhysiologyAnatomy-Physiology

    MetabolismObesityblood pressurecardiac functioncardiovascularmetabolic syndromerenalRespirationrespiratory system
    Lesson
    2637

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    683

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    Teaching Biodiversity with Museum Specimens in an Inquiry-Based Lab
    In response to the growth of biology datasets and broad efforts to digitize data, an increasingly important skill for science students is the management and analysis of large datasets. We designed an inquiry-based lab module to introduce students...

    Courses: EcologyEcology EvolutionEvolution Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    data analysisnatural historyphylogenyBiodiversitymammalsAllen's RuleBergmann's Ruleecogeographymuseum research
    Science Behind the Lesson
    1343

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    186

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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2)...

    Courses: Anatomy-PhysiologyAnatomy-Physiology GeneticsGenetics

    protein structure and functionhuman genetic variationskeletal muscle physiology
    Lesson
    1128

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    335

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    The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories
    Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and implement due to limited time and resources. We...

    Courses: Anatomy-PhysiologyAnatomy-Physiology GeneticsGenetics

    protein structure and functionhuman genetic variationmuscle physiology
    Lesson
    672

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    41

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    Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism
    A thorough understanding of glycolysis forms a foundation for students to analyze subsequent topics in metabolism, a core competency recognized by multiple national societies for biology and biochemistry. However, when confronted with the names of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    Problem based learningPOGILenzymesGlycolysisMetabolismFermentationchemical reactionsCard sorting activityCofactors
    Lesson
    1515

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    202

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    Building student literacy and metacognition through reading science in the news
    Ensuring students' science literacy is essential for preparation for study in science disciplines and is of critical importance given contemporary challenges in determining the legitimacy and accuracy of science in popular media. This lesson...

    Courses: Introductory BiologyIntroductory Biology

    metacognitionStem cellsscience literacycloninggenetically modified organismshuman genetic diseasescience news
    Lesson
    2592

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    114

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    Film as a Powerful Tool for Increasing Awareness of the Importance of Belonging in STEM
    People of color in STEM fields can face a variety of challenges with belonging due to structural, cultural, psychological, and institutional barriers. The professional development sessions described in this lesson involved using film as well as...

    Courses: Professional Development and Career PlanningProfessional Development and Career Planning

    steminclusionfilmbelonging
    Lesson
    4759

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    612

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    How Do Kidneys Make Urine From Blood? Qualitative and Quantitative Approaches to Filtration, Secretion, Reabsorption, and Excretion
    The function of the kidneys is to help maintain a constant internal environment (homeostasis) by regulating the volume and chemical composition of the blood. This regulation occurs via three fundamental processes: filtration, secretion, and...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Introductory BiologyIntroductory Biology

    collecting ductexcretionglomerular filtration rate (GFR)nephron tubulereabsorptionrenal corpusclesection
    Lesson
    4756

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    641

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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate
    Lesson
    2706

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    384

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    Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples
    Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the environment, and gene-by-environment interactions...

    Courses: EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology

    genesenvironmentMendelQuantitative traitsMultifactorialGene by environment interactions
    Lesson
    1478

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    324

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    Investigating Gene Expression and Cell Specialization in Axolotl Embryos
    The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology Developmental BiologyDevelopmental Biology Science Process SkillsScience Process Skills

    developmenttranscriptiongene expressionmodel organismembryo
    Lesson
    1692

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    304

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    Authentic Ecological Inquiries Using BearCam Archives
    Learning through authentic scientific inquiries is essential for understanding the nature and process of science and for developing critical thinking and communication skills. It is logistically challenging, however, to offer experiences of...

    Courses: EcologyEcology Science Process SkillsScience Process Skills

    behaviorinterspecific interactionsPeer reviewauthentic inquiryintra-specific interactions
    Lesson
    2118

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    403

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    Dynamic Daphnia: An inquiry-based research experience in ecology that teaches the scientific process to first-year biologists
    This authentic research experience lesson teaches the core concept of systems and the competencies of quantitative reasoning, communication, and the ability to apply science. The research is student driven, the results are unknown, and the...

    Courses: EcologyEcology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    statisticsecologyscientific methodexperimental designAbiotic and Biotic FactorsDependent and Independent Variables