CourseSource: Resources

Essay

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121

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An Active Textbook Converts "Vision and Tweak" to Vision and Change

Multiple reports over more than a century have documented the problems with the way introductory biology has been taught in most colleges and universities. An influential recent report, Vision and Change in Undergraduate Biology Education, has...

Courses: Introductory Biology

Vision and Changeactive learningintroductory biologyFlipped classroomUndergraduatecore competenciescore conceptsactive textbookcurriculum reform

Lesson

5285

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693

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Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course

A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

Courses: Biochemistry and Molecular Biology Introductory Biology

structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

Essay

827

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125

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Implementing active learning approaches into an upper-division biology course

In this essay, we present our strategy for implementing active learning strategies into an upper division course on Human Genetics. Our principal goal was to shift from a traditional didactic course design, to one that more clearly placed the...

Courses: Genetics Introductory Biology

human biologyPedigree analysisRare genetic diseases

Lesson

1020

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258

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0

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Helping Students to Metacognitively Read Scientific Literature With Talking to the Text

Reading primary scientific literature enhances students’ understanding of material, increases their self-efficacy, and critical thinking skills. However, scientific articles often present multiple challenges to the students, the first among...

Courses: Introductory Biology Science Process Skills

scientific literaturereading comprehensionmetacognitionScience process skillsTalking to the TextDense Scientific Texts

Lesson

980

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122

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My Fish Tank: An Active Learning Activity for Bacterial Nitrogen Metabolism

This active learning activity introduces students to the second part of the nitrogen cycle, nitrification. In terrestrial and aquatic environments, bacteria from the Nitrosomonas and Nitrobacter genera oxidize ammonia first to nitrite (via a...

Courses: Biochemistry and Molecular Biology Ecology Ecology Microbiology

nitrogen cyclenitrificationnitrifying bacteria

Lesson

2228

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445

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Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms

Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell division off balance. Communication of these...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

mutationcancertranscriptioncell cycletranslationOncogenesTumor-suppressorp53Transcription factor

Lesson

2597

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487

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0

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A Modeling Exercise in Sexual Selection using a Student-Created Bird Species

Evolution-centered lessons at the undergraduate level can often be jargon-heavy, propagate misconceptions if taught ineffectively, and be uninteresting to students who may not see the relevancy of such concepts. This activity provides a fun and...

Courses: Ecology Ecology Evolution Introductory Biology

Evolutionfitnesssexual selectionNatural Selectionintersexual selectionmate choice

Lesson

2829

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738

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Electron Location, Location, Location: Understanding Biological Interactions

Introductory Biology courses typically introduce the structure and function of biomolecules such as proteins and nucleic acids. To understand biomolecules fully, students require knowledge of fundamental chemistry concepts such as covalent...

Courses: Biochemistry and Molecular Biology Introductory Biology

hydrogen bondshydrophobicity/hydrophilicitypolar and non-polar covalent bonds

Lesson

3406

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285

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0

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Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype

Lesson

427

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63

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0

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The Science and Ethics of Gene Drives: An Active Learning Lesson in Genetics

Coursework connecting biology to socially relevant issues and ethical questions can help students think about biology in interdisciplinary terms. Gene drives represent one topic involving both advanced biology concepts and societally relevant...

Courses: Genetics

bioethicsCRISPR/Cas9Genetic modificationGene drives

Lesson

1465

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110

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Introducing Immunology Research Literature to Understand B-cell Receptor Gene Expression

Immunology is relevant to our everyday lives, driving a need for more engaging and inclusive undergraduate immunology education. One way to engage a diverse group of learners is by teaching them how to read and interpret the scientific literature....

Courses: Immunology Science Process Skills

recombinationantibodyV(D)J recombinationB-cell receptorlymphocyte receptor

Lesson

1694

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285

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0

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Using Comics to Make Science Come Alive

Students often see science as a fragmented set of facts to be memorized, rather than concepts and processes that are relevant in their everyday lives. This is especially true for non-science majors, who represent the vast majority of all college...

Courses: Ecology Ecology Genetics Introductory Biology Neurobiology

role of science in society

Lesson

4465

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447

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1

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Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

Courses: Biochemistry and Molecular Biology

gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

Lesson

7958

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396

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0

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Investigating Cell Signaling with Gene Expression Datasets

Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

Courses: Biochemistry and Molecular Biology Cell Biology

genomicstranscriptionsignaling

Lesson

3696

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827

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Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition

Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be difficult for students to grasp when instructed...

Courses: Biochemistry and Molecular Biology Cell Biology

kineticsEnzymecompetitive inhibition

Lesson

2981

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349

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Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding

This lesson introduces beginning biochemistry students to the concept of a biomolecule binding site, such as a neurotransmitter receptor site or an enzyme active site. A simple organic molecule, the neurotransmitter serotonin, is the focus of the...

Courses: Biochemistry and Molecular Biology

active sitebindingbinding sitehydrogen bondinghydrophobic effectionic interactionsnon-covalent forces

Lesson

5546

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2661

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Cell Signaling Pathways - a Case Study Approach

Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

Courses: Cell Biology Developmental Biology

signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

Lesson

4108

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596

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics Introductory Biology

gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

Lesson

771

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256

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A Kinesthetic and Collaborative Activity to Improve Conceptual Understanding of Chemical Equilibrium

While teaching in large lecture halls, it is challenging even for experienced teachers to hold their students’ attention for the entire class period. Owing to the large enrollment in STEM introductory courses, it is especially crucial to...

Courses: Biochemistry and Molecular Biology Science Process Skills

collaborationdemonstrationchemistrykinesthetic learningequilibriumhands-on learning

Lesson

1280

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404

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Teaching the Biological Relevance of Chemical Kinetics Using Cold-Blooded Animal Biology

This lesson plan was created to support non-chemistry major students in making connections between chemical kinetics and biological systems. Chemical kinetics is often viewed by students as an abstract topic, and one that is limited only to...

Courses: Introductory Biology Science Process Skills

kineticsMetabolismEctothermPoikilotherm