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    Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology
    At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors
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    5054

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    914

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    Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy
    Analyzing high-throughput DNA sequence data is a fundamental skill in modern biology. However, real and perceived barriers such as massive file sizes, substantial computational requirements, and lack of instructor background knowledge can...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics

    bioinformaticsDNA sequenceRNAseqgene expression
    Lesson
    7984

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    398

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    genomicstranscriptionsignaling
    Lesson
    1745

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    432

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    How to Find a Gene: Retrieving Information From Gene Databases
    A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    NCBItranscriptiontranslationGene StructureGene databasesEnsembl
    Lesson
    456

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    68

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    The Science and Ethics of Gene Drives: An Active Learning Lesson in Genetics
    Coursework connecting biology to socially relevant issues and ethical questions can help students think about biology in interdisciplinary terms. Gene drives represent one topic involving both advanced biology concepts and societally relevant...

    Courses: GeneticsGenetics

    bioethicsCRISPR/Cas9Genetic modificationGene drives
    Teaching Tools and Strategies
    2832

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    394

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    The Flight Physics Concept Inventory: Reliably Evaluating Aerodynamic Lift, Drag and Associated (Naïve) Concepts of Flight in Class and In-Game
    Students often struggle to transfer conceptual understanding from isolated instruction to a coherent mental model. This is especially true for the context of flight physics, fluid dynamics, or the concepts of aerodynamic lift, drag, stall, center...

    Courses: Introductory Physics: Calculus-BasedIntroductory Physics: Calculus-Based

    active learninggamificationmisconceptionsaerodynamicsfluid dynamicsResearch-based assessment instrumentConceptual SurveyPRE-/POST-test
    Lesson
    1431

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    144

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    Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism
    A thorough understanding of glycolysis forms a foundation for students to analyze subsequent topics in metabolism, a core competency recognized by multiple national societies for biology and biochemistry. However, when confronted with the names of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    Problem based learningguided inquiryenzymesGlycolysisMetabolismFermentationchemical reactionsCard sorting activityCofactors
    Lesson
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    618

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    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    mutationcentral dogmatranslationframeshift
    Lesson
    79

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    6

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    A Day in the Life of a Plant Breeder: A Role-Playing Game Integrating Plant Breeding Decisions to Downstream Market Outcomes
    Undergraduate genetics courses often have a strong molecular and mathematical focus without an applied framework illustrating downstream impacts of genetic decisions, especially within a plant breeding perspective. Subsequently, content tends to...

    Courses: GeneticsGenetics Plant BiologyPlant Biology

    active learningsystems thinkingphenotypeplant geneticsGame Based Learningplant breedingrole-playing
    Lesson
    2652

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    263

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    Pick Your Poison: A Semester-Long Case Study for Undergraduate Toxicology
    The ability to collate information from diverse scientific resources and effectively employ scientific writing is an essential skill for scientists. This lesson describes a semester-long project entitled “Pick Your Poison,” which is...

    Courses: ToxicologyToxicology

    risk assessmenttoxicologyPharmacologyregulationsdose responseADME
    Lesson
    5743

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    986

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    A clicker-based case study that untangles student thinking about the processes in the central dogma
    The central dogma of biology is a foundational concept that provides a scaffold to understand how genetic information flows in biological systems. Despite its importance, undergraduate students often poorly understand central dogma processes (DNA...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationtranscriptionphenotypecentral dogmatranslationDNA replication
    Lesson
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    917

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    Assessing Urban Biodiversity With the eBird Citizen Science Project: A Course-Based Undergraduate Research Experience (CURE) Module
    The eBird citizen science module takes advantage of technology tools and online resources developed by the Cornell Laboratory of Ornithology (http://ebird.org) to achieve several learning objectives embedded in a semester-long upper-level biology...

    Courses: EcologyEcology Science Process SkillsScience Process Skills

    datacitizen sciencecommunityBiodiversitySpecieshypothesishabitat
    Lesson
    1452

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    393

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    Data, Distributions, and Hypotheses: Exploring Diversity and Disturbance in the Tallgrass Prairie
    Proper hypothesis generation, data handling, graphing, and communication are essential skills that undergraduate majors in biology are expected to master. However, students rarely get hands-on practice that helps them to effectively develop these...

    Courses: EcologyEcology Plant BiologyPlant Biology

    Quantitative reasoningRestoration EcologyScience process skillstall grass prairie ecosystem
    Teaching Tools and Strategies
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    327

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    SCIENCE/Fiction: Modular Template for Class Design
    We present a modular scaffold for designing an introductory seminar using speculative fiction and science papers to welcome university undergraduates to the biology major. A list of twelve possible topics is included, such as Memory, Parasites,...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology NeurobiologyNeurobiology

    geneticscell biologyneurosciencesystems biologyScience Fiction
    Lesson
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    170

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    Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes
    Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills to analyze biological data while understanding the...

    Courses: BioinformaticsBioinformatics

    computationpythonJupyter notebookFunctionscentral dogmaDictionaries
    Lesson
    4085

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    487

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    A Classroom Intervention to Reduce Confirmation Bias
    STEM students are often unable to recognize cognitive bias in their own disciplines, and simply describing cognitive bias to students has shown to be insufficient to improve critical thinking. However, habitual metacognitive techniques show...

    Courses: Science Process SkillsScience Process Skills

    biasprocess of sciencemetacognitionConfirmation BiasCognitive Bias
    Lesson
    995

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    137

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    BioMap Degree Plan: A project to guide students in exploring, defining, and building a plan to achieve career goals
    Traditional college students begin their academic journey with a variety of ideas about the careers they might ultimately pursue. Some students have always known what they want to do, some have ideas about possible careers, while others have never...

    Courses: Introductory BiologyIntroductory Biology Professional Development and Career PlanningProfessional Development and Career Planning

    Career ExplorationCo-curricularsDegree Planning
    Lesson
    3423

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    287

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    Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology
    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype
    Teaching Tools and Strategies
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    235

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    Preparing Student Study Guides through Peer Collaboration in the Technological Era
    Incorporating active learning exercises into large lecture courses is particularly challenging, especially when it comes to examination preparation materials. Traditionally, study guides are used as a tool to guide student learning and review...

    Courses: Introductory BiologyIntroductory Biology Professional Development and Career PlanningProfessional Development and Career Planning Science Process SkillsScience Process Skills

    active learningDiscussionStudy Skills
    Lesson
    1686

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    314

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    Understanding Host-Pathogen Interactions With the Use of Galleria mellonella
    The Galleria mellonella; the larvae of the Greater Wax Moth, is a safe and effective means to study host-pathogen interactions in the undergraduate setting. The use of animal models in the teaching classroom provides an opportunity to discuss...

    Courses: ImmunologyImmunology MicrobiologyMicrobiology

    innate immunitybacterial pathogenesisHost-pathogen interactionsGalleria mellonellaVirulence