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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics

    gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway
    Lesson
    5546

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    2661

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    Cell Signaling Pathways - a Case Study Approach
    Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

    Courses: Cell BiologyCell Biology Developmental BiologyDevelopmental Biology

    signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity
    Lesson
    4485

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    718

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    Problem-Based Learning for Physiology: Synthesizing the Cardiovascular System, Respiration, Macronutrient Metabolism, and Renal Function
    Problem Based Learning (PBL) is a valuable tool for helping students overcome reliance on memorization by scaffolding opportunities for them to practice the competency of “systems thinking,” which is the ability to understand...

    Courses: Anatomy-PhysiologyAnatomy-Physiology

    MetabolismObesityblood pressurecardiac functioncardiovascularmetabolic syndromerenalRespirationrespiratory system
    Lesson
    980

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    122

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    My Fish Tank: An Active Learning Activity for Bacterial Nitrogen Metabolism
    This active learning activity introduces students to the second part of the nitrogen cycle, nitrification. In terrestrial and aquatic environments, bacteria from the Nitrosomonas and Nitrobacter genera oxidize ammonia first to nitrite (via a...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology EcologyEcology MicrobiologyMicrobiology

    nitrogen cyclenitrificationnitrifying bacteria
    Lesson
    1345

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    122

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    Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism
    A thorough understanding of glycolysis forms a foundation for students to analyze subsequent topics in metabolism, a core competency recognized by multiple national societies for biology and biochemistry. However, when confronted with the names of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    Problem based learningguided inquiryenzymesGlycolysisMetabolismFermentationchemical reactionsCard sorting activityCofactors
    Lesson
    3036

    views

    207

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    0

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    The Three Sisters of Agriculture: An Active Learning Activity on Symbiotic Nitrogen Fixation
    This active learning exercise introduces students to the plant microbiome and the contributions that bacteria make to plant growth and food production. The Three Sisters are an ancient indigenous practice in which three plant crops and the...

    Courses: MicrobiologyMicrobiology

    SymbiosisPlant microbiomeNitrogen fixationNutritional content of foodElectron flowSociety impact of microorganisms
    Science Behind the Lesson
    1479

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    202

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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2)...

    Courses: Anatomy-PhysiologyAnatomy-Physiology GeneticsGenetics

    protein structure and functionhuman genetic variationskeletal muscle physiology
    Lesson
    3549

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    263

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    SEAS CURE: Exploring Coral Biology Across Scales
    Complex biological concepts (like symbiosis and coral biology) that span multiple scales and cross disciplinary boundaries are often difficult for students to understand. This complexity is compounded by the challenges inherent to teaching and...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Cell BiologyCell Biology EcologyEcology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    microscopyAnatomySymbiosisMetabolismbleachinginvertebratedinoflagellate
    Lesson
    3682

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    270

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    Bringing Pasteur Back to Life: Studying the Biochemistry of Yeast Fermentation Through Discussion Groups and an At-Home Lab
    This hands-on, student-centered biochemistry lesson introduces beginner biochemistry students to the techniques of effectively reading and discussing primary literature, identifying fundamental biological concepts, and applying that knowledge to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    primary literatureexperimentationyeastMetabolismFermentationRespirationequilibrium
    Lesson
    5284

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    693

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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate
    Teaching Tools and Strategies
    5656

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    820

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    Science “Fails”: A Bank of Historical Examples for Learning From Failure in Science
    Learning from failure is critically important to the processes of scientific inquiry, discovery, and invention. However, students are not routinely taught how to reflect on, learn from, and ultimately embrace failure, and relatively few curricular...

    Courses: Introductory Physics: Calculus-BasedIntroductory Physics: Calculus-Based Introductory BiologyIntroductory Biology Professional Development and Career PlanningProfessional Development and Career Planning Science Process SkillsScience Process Skills

    metacognitionScience process skillsLearning from failurepower and privilegestudent wellbeing
    Lesson
    2829

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    738

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    Electron Location, Location, Location: Understanding Biological Interactions
    Introductory Biology courses typically introduce the structure and function of biomolecules such as proteins and nucleic acids. To understand biomolecules fully, students require knowledge of fundamental chemistry concepts such as covalent...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    hydrogen bondshydrophobicity/hydrophilicitypolar and non-polar covalent bonds
    Lesson
    1654

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    222

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    Building student literacy and metacognition through reading science in the news
    Ensuring students' science literacy is essential for preparation for study in science disciplines and is of critical importance given contemporary challenges in determining the legitimacy and accuracy of science in popular media. This lesson...

    Courses: Introductory BiologyIntroductory Biology

    metacognitionStem cellsscience literacycloninggenetically modified organismshuman genetic diseasescience news
    Lesson
    2269

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    455

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    A Short Laboratory Module to Help Infuse Metacognition during an Introductory Course-based Research Experience
    A core competency identified in Vision and Change for undergraduate biology students is the Ability to Apply the Process of Science. Here, we describe a three-week laboratory module for students in an Introductory Cell and Molecular Biology...

    Courses: Science Process SkillsScience Process Skills

    metacognitiongene expressionScientific ProcessExperimenal DesignHypothesis Generationmodel organisms
    Lesson
    3339

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    275

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    Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience
    Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience tailored for junior and senior undergraduate biology...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics MicrobiologyMicrobiology

    EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs
    Lesson
    2918

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    362

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    Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study
    Our interdisciplinary pedagogical case study explores the differences between rural and urban coyotes at the levels of organismal and community ecology. The focus is on how coyotes’ gut microbiomes could affect their behavior via...

    Courses: Cell BiologyCell Biology EcologyEcology EvolutionEvolution ImmunologyImmunology Introductory BiologyIntroductory Biology MicrobiologyMicrobiology

    dietanimal behaviorimmune systemmicrobiomeNervous systemgut-brain axisImmunoReachdysbiosisCoyoteCytokines
    Lesson
    5057

    views

    667

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    How Do Kidneys Make Urine From Blood? Qualitative and Quantitative Approaches to Filtration, Secretion, Reabsorption, and Excretion
    The function of the kidneys is to help maintain a constant internal environment (homeostasis) by regulating the volume and chemical composition of the blood. This regulation occurs via three fundamental processes: filtration, secretion, and...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Introductory BiologyIntroductory Biology

    collecting ductexcretionglomerular filtration rate (GFR)nephron tubulereabsorptionrenal corpusclesection
    Lesson
    3155

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    457

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    Small Organisms with Big Consequences: Understanding the Microbial World Around Us
    Creating a hands-on lab that conveys important information while simultaneously allowing for student autonomy can be difficult. This is particularly true for the field of microbiology, in which labs often rely on “recipe-style”...

    Courses: Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    disease transmissionmicrobiologymicrobiomeliterature reviewPeer reviewPathogensHealth and WellnessThe Scientific Method
    Lesson
    18760

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    406

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    A flexible, multi-week approach to plant biology - How will plants respond to higher levels of CO2?
    To help introductory biology students understand how plants will respond to higher levels of CO2, we have created a multi-week module consisting of a series of four related laboratory lessons. These lessons allow students to make connections among...

    Courses: Introductory BiologyIntroductory Biology Plant BiologyPlant Biology

    statisticsplantsphotosynthesiscarbon dioxidecommunicating sciencegroup workResource AllocationRespirationStomata
    Lesson
    1390

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    393

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    Where Does Elsie's Hair Color Come From? A "De-Simplified" Pedigree Lesson
    Pedigree analysis is part of most Genetics curricula, but the examples traditionally used in genetics courses present phenotypes as if they were entirely and inexorably defined by genotype. This does not reflect the current state of understanding...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology

    pedigreeMultifactorialphenotypic variationpenetranceexpressivityquantitative variation