CourseSource: Resources

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Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners

Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

Courses: Developmental Biology Genetics

mathematical modelhomologous recombinationCre/loxgene targeting

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397

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59

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The Science and Ethics of Gene Drives: An Active Learning Lesson in Genetics

Coursework connecting biology to socially relevant issues and ethical questions can help students think about biology in interdisciplinary terms. Gene drives represent one topic involving both advanced biology concepts and societally relevant...

Courses: Genetics

bioethicsCRISPR/Cas9Genetic modificationGene drives

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1706

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406

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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3090

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488

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Targeting Misconceptions in the Central Dogma by Examining Viral Infection

Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary connections between DNA structure, transcription,...

Courses: Genetics Introductory Biology

datatranscriptionvirustranslationprotein functionmembrane transportPredictions

Science Behind the Lesson

600

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49

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X-ploring Fragile X: The Science Behind the Syndrome

Fragile X Syndrome is an X-linked genetic disorder resulting from the impairment of transcription of the FMR1 gene, producing less to no FMRP protein. FMRP is a translational inhibitor that plays a key role in neurological development. Recent...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

epigeneticsgene regulationtranscriptioncentral dogmatranslationFragile X syndromeSphingosine Metabolism

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3312

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1175

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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3459

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1289

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A CRISPR/Cas Guide RNA Design In Silico Activity

CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics

bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico

Review

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235

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Workshop Report: Summer 2020 Virtual CRISPR in the Classroom

As innovations and developments in genome editing technologies using CRISPR-Cas systems progress, the need to disseminate relevant knowledge and build skills among the next generation of young scientists in undergraduate classrooms is vital. Our...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Professional Development and Career Planning

geneticscrisprGenome Analysisgene editingbacterial immunity

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2559

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A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed a laboratory module to provide a guided research...

Courses: Bioinformatics Cell Biology Developmental Biology Genetics Science Process Skills

microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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5634

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970

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A clicker-based case study that untangles student thinking about the processes in the central dogma

The central dogma of biology is a foundational concept that provides a scaffold to understand how genetic information flows in biological systems. Despite its importance, undergraduate students often poorly understand central dogma processes (DNA...

Courses: Genetics Introductory Biology

mutationtranscriptionphenotypecentral dogmatranslationDNA replication

Lesson

3584

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3237

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Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design

One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy disciplines such as molecular biology, where emphasis...

Courses: Biochemistry and Molecular Biology

experimental designcrisprmolecular technique

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881

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46

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A Structured Inquiry-Based Module for the Undergraduate Cell Biology Laboratory That Teaches Fundamental Concepts of Cell Differentiation

Pedagogical research in science education has shown that students effectively learn science by doing science. As a result, there is increased interest in bringing research-like experiences into the classroom, particularly for laboratory courses....

Courses: Cell Biology

fluorescence microscopygene expressionpolymerase chain reactionCell Structurecell culturewestern blottingdifferentiationreverse transcription

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1576

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341

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Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...

Courses: Biochemistry and Molecular Biology Cell Biology Developmental Biology Science Process Skills

developmenttranscriptiongene expressionmodel organismembryo

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516

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74

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Using Raw Sequence Data to Analyze Tumor Suppressor Mutations

Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to map DNA sequence variants to functional regions...

Courses: Bioinformatics Genetics

bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

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From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important challenge is how we design curricula to foster...

Courses: Developmental Biology

experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish

Teaching Tools and Strategies

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DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.

Advances in high-throughput techniques have resulted in a rising demand for scientists with basic bioinformatics skills as well as workshops and curricula that teach students bioinformatics concepts. DNA Detective is a workshop we designed to...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Plant Biology

geneticsbioinformaticsDNAgenotypephenotypegenegene annotation

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2172

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Antibiotic Resistance Genes Detection in Environmental Samples

Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This lab series teaches transferable and universal...

Courses: Introductory Biology Microbiology Science Process Skills

geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry

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Differential Gene Expression during Xenopus laevis Development

In Developmental Biology classes, students are challenged with understanding how differential gene expression guides embryonic development. It can be difficult for students to realize that genes need to be turned on or off at the right time and...

Courses: Developmental Biology

gene expressionXenopusearly developmentembryofertilizationin situ hybridization

Teaching Tools and Strategies

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Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab

The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab course to an online version in Spring 2020. The lab...

Courses: Genetics Science Process Skills

mutationtranscriptioncrisprtranslation

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4296

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What is Speciation, How Does It Occur, and Why Is It Important for Conservation?

Speciation provides a framework for classifying biodiversity on Earth and is a central concept in evolutionary biology. To help undergraduate students learn about speciation, we designed a student-centered lesson that uses active-learning...

Courses: Ecology Ecology Genetics Introductory Biology Science Process Skills