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Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for...
bioinformatics cancer transcriptomics high-throughput Data wrangling Single cell RNA sequencingq
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Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication
In order to function correctly, proteins must be localized to a specific subcellular location. We have designed this lesson to use data from the primary literature to teach students about the mechanisms cells use to direct proteins to the...

Courses: Cell BiologyCell Biology

colocalization immunofluorescence Protein localization signal sequences subcellular fractionation western blotting
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Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition
Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be difficult for students to grasp when instructed...
kinetics Enzyme competitive inhibition
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Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
The extracellular matrix (ECM) provides structural support to cells, but also has key roles in mediating cell adhesion, cell signaling, and differentiation. While this topic is discussed in the lecture setting, it is not heavily studied in...
Neural extracellular matrix Perineuronal net Primary neuronal culture
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Nanoparticles and Shrimp: An Interdisciplinary Lab Series in Chemistry and Biology for Undergraduate Engineering Students
The parallels between engineering and science are vast, as both disciplines apply theory and inquiry to solve complex problems. In order to prepare students for interdisciplinary careers in STEM, we have developed a lab project in which...
microscopy chemistry applications in biology toxicity
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Going Remote: An Online Adaptation to Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
In light of the COVID-19 pandemic, instructors have modified materials to transition to a remote learning platform. The challenge for science instructors has been to design lab exercises that incorporate both active and experiential learning. In...
remote learning Extracellular matrix Neural extracellular matrix Perineuronal net
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Modeling Strep Throat Detection, Infection, and Spread Using an SIR Model and the Vensim Simulation Software
The overarching goal of this lesson is to provide students with an opportunity to gain experience making and using biological models. Biological modeling can be used to investigate complex, real-world problems so that predictions can be made about...
infectious disease biological modeling SIR model
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Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function
As instructors of introductory biology courses for majors and non-majors, we have struggled with teaching the concept of cell structure and function in an engaging way.  However, this is a foundational concept that most biology instructors...
cell function Cell Structure Cellular diversity Dynamic cellular function Organelle function
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Investigating Gene Expression and Cell Specialization in Axolotl Embryos
The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...
development transcription gene expression embryo
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Tying it All Together: An Activity to Help Students Connect Course Experiences to Posted Learning Outcomes
Instructors of undergraduate courses in Biology and other Science, Technology, Engineering, and Mathematics (STEM) disciplines face an ongoing challenge to foster higher-order thinking and learning skills while also developing a sound conceptual...
metacognition reflection goals Outcomes
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Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs that disrupt activities associated with mitosis and...
fluorescence microscopy mitosis Cell Structure Cell Imaging Immunocytochemistry Quantitative microscopy STEM skills
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Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division students' understanding of the proteins that...

Courses: Cell BiologyCell Biology

Diffusion Active transport facilitated diffusion Necessary and sufficient Transport proteins
Essay
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Structuring Courses for Equity
As instructors, we continually look for new ways to create equitable learning environments and support learning for all students in our courses. Recently, we have explored ways that we can increase structure to better support students. We have...
Equity metacognition inclusivity course structure
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Translating Co-Translational Translocation
Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also determines the resulting protein topology, is a complex...

Courses: Cell BiologyCell Biology

Topology co-translational translocation endoplasmic reticulum protease protection assay secretory proteins signal sequence transmembrane proteins
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Teaching students to read, interpret, and write about scientific research: A press release assignment in a large, lower-division class
A central skill in any science discipline is the ability to read, understand, and discuss the primary literature of the discipline. However, teaching this skill presents unique challenges within large, lower-division courses. To assess our...
cell biology Science Communication scientific literacy Graduate Teaching Assistant Professional Development Biological Literacy Primary Research Writing Skills