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Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for...
bioinformatics cancer transcriptomics high-throughput Data wrangling Single cell RNA sequencingq
Lesson
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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...
bioinformatics Genome Browser genomics RNAseq splicing Computer Model Gene Structure
Lesson
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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway
Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions.  This laboratory lesson helps students to understand the...
Selection yeast Metabolism cysteine media methionine mutant Pathway sulfur
Lesson
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Using Comics to Make Science Come Alive
Students often see science as a fragmented set of facts to be memorized, rather than concepts and processes that are relevant in their everyday lives. This is especially true for non-science majors, who represent the vast majority of all college...
role of science in society
Teaching Tools and Strategies
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Drawing flowcharts of lab protocols helps students prepare for biology labs
With the publishing of the Vision and Change report, we know it is best practice to include authentic research experiences in our undergraduate science lab classes. One big challenge in teaching so-called "wet lab" classes is figuring...
laboratory molecular biology Undergraduate protocol flowchart
Teaching Tools and Strategies
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Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab
The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab course to an online version in Spring 2020. The lab...
mutation transcription crispr translation
Lesson
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Cutthroat trout in Colorado: A case study connecting evolution and conservation
Evaluation of evidence is a key process skill for the core competencies of applying the process of science and using quantitative reasoning. This case study enables upper-division biology students to practice these skills by applying evolutionary...
population genetics phylogenetics Speciation divergence gene flow
Lesson
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Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience
Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...
genetics bioinformatics drosophila chi-square analysis complementation mapping mode of inheritance three-point mapping
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A CRISPR/Cas Guide RNA Design In Silico Activity
CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...
bioinformatics gene expression genetic basis of disease CRISPR/Cas9 genetic engineering in silico
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What is Speciation, How Does It Occur, and Why Is It Important for Conservation?
Speciation provides a framework for classifying biodiversity on Earth and is a central concept in evolutionary biology. To help undergraduate students learn about speciation, we designed a student-centered lesson that uses active-learning...
Evolution conservation Genetic Drift Speciation Natural Selection Biological species concept gene flow Morphological species concept Phylogenetic species concept
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Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts
Many video resources exist to teach Mendelian genetics, but most consist of passive delivery of information rather than active construction of knowledge by users. We have created two interactive video vignettes (IVVs) that can be used together or...
genotype phenotype alleles pedigree dominance Hardy-Weinberg equilibrium Inheritance
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My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships
To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...
gel electrophoresis sequence analysis canine genetics deoxyribonucleic acid (DNA) dog coat morphology genotype and phenotype mutations Polymerase chain reaction (PCR) single nucleotide polymorphism (SNP)
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Tying it All Together: An Activity to Help Students Connect Course Experiences to Posted Learning Outcomes
Instructors of undergraduate courses in Biology and other Science, Technology, Engineering, and Mathematics (STEM) disciplines face an ongoing challenge to foster higher-order thinking and learning skills while also developing a sound conceptual...
metacognition reflection goals Outcomes
Essay
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Structuring Courses for Equity
As instructors, we continually look for new ways to create equitable learning environments and support learning for all students in our courses. Recently, we have explored ways that we can increase structure to better support students. We have...
Equity metacognition inclusivity course structure
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Fruit Fly Genetics in a Day: A Guided Exploration to Help Many Large Sections of Beginning Students Uncover the Secrets of Sex-linked Inheritance
Moving beyond the basic concepts of autosomal Mendelian inheritance to sex-linkage can be difficult for introductory biology students. Although crosses with Drosophila fruit flies have long been a mainstay of genetics units that teach these...

Courses: GeneticsGenetics

Mendelian Genetics fruit fly biology sex-linked inheritance