Lecture 3 - Protein Structure-Function Exploration - an aligned initiative with bioinformatics analysis: A balanced route in Proteomics
The CURESUB Lecture Series
Friday, March 18th 2022
1:00 PM Eastern
Zoom Link
Dr. Vishwa Trivedi
Associate Professor of Chemistry/Biochemistry Bethune Cookman University
SPEAKER BIO
Vishwa D. Trivedi is an Associate Professor of Biochemistry at Bethune Cookman University, Daytona Beach. He obtained his doctoral training in Protein Chemistry from Center for Cellular and Molecular Biology. As the chemistry/Biochemistry program faculty at BCU, Vishwa Trivedi is involved with teaching broad range of undergraduate courses along with active research. Prior to joining BCU, Dr. Trivedi served as instructor at Center for Membrane Biology [in Department of Biochemistry and Molecular Biology] of University of Texas-Houston Medical School. He has served as research fellow at several premier research institutions and worked on protein structure-function projects involving NMR and x-ray crystallography of fusion domains of influenza, HIV-1 gp41 and novel microbial photomedicated signaling partners.
Dr. Trivedi prefers to promote concept based learning with emphasis of critical thinking and reasoning along with motivation and individual attention to advance new generation in 21st century scientific need. He has served as reviewer and panelist to various journals and programs respectively. Recently he has completed a 5 year NIH-supported project serving as Principal Investigator and guided numerous researchers in his “Protein Chemistry Research Group” at B-CU.
ABSTRACT
The dynamic role of proteins [originated from Proteios (ranked first)] to support the life is evident since the initial stages of biological research. The term “ProteOMICS” was first used by Marc Wilkins in 1996 to denote the “PROTein complement of a genOME”. High throughput tools [NMR and X-ray crystallography] along with bioinformatics analysis served as power resources with expanding database. From the first sequence of insulin, to prediction of secondary structural motif and successful very first structural determination till now the information and database expanded exponentially. Even very first high resolution membrane protein x-ray structure appeared in 1985, the electron crystallography analysis of bacteriorhodopsin provided first structural identification of α-helices in membrane proteins during 1975. In our PSFE initiatives we connected our research interest to undergraduate curriculum by infusing comparative structural analysis of novel microbial rhodopsin-transducer pair along with characterization of DUF (Domain of Unknown Function) members using structural and bioinformatics approach. Such an balanced and aligned approach is unique in proteomics.