HITS

Case Studies

Resources

In the summer of 2018 at the first HITS workshop at NC State University, the group began working on a set of learning outcomes for cases studies using high-throughput (HT) data sets and discovery science. These outcomes focus on quantitative skills students will strengthen using case studies produced by HITS. The HITS community will continue to refine the learning outcomes and skills in this document. We encourage the community to provide comments and feedback as we refine the learning outcomes and create HT case studies.

Learning Outcomes and Skills for HT Case Studies (link to view document)

HITS Case Study Resources

• Robertson SD, Bixler A, Eslinger MR, Gaudier-Diaz MM, Kleinschmit AJ, Marsteller P, O’Toole KK, Sankar U and Goller CC. 2021. HITS: Harnessing a Collaborative Training Network to Create Case Studies that Integrate High-Throughput, Complex Datasets into Curricula. Front. Educ. 6:711512. doi: 10.3389/feduc.2021.711512
• Bixler A, Eslinger M, Kleinschmit AJ, Gaudier-Diaz MM, Sankar U, Marsteller P, Goller CC, Robertson S. (2021). Three Steps to Adapt Case Studies for Synchronous and Asynchronous Online Learning. J Microbiol Biol Educ. 2021 Mar 31;22(1):22.1.22. doi: 10.1128/jmbe.v22i1.2337. PMID: 33884065; PMCID: PMC8012036.

HITS Case Studies:

• Carr SA, Mathews SL, Pruneski JA, Stasulli NM. 0. A case study to engage students in evolutionary thinking around antibiotic resistance using the MEGA-plate experiment. J Microbiol Biol Educ. 0:e00039-24.https://doi.org/10.1128/jmbe.00039-24

• Pomeroy, A. E., Bixler, A., Chen, S. H., Kerr, J. E., Levine, T. D., & Ryder, E. F. (2024, March). “R” U ready?: a case study using R to analyze changes in gene expression during evolution. In Frontiers in Education (Vol. 9, p. 1379910). Frontiers Media SA. https://www.frontiersin.org/articles/10.3389/feduc.2024.1379910/full

• Kleinschmit AJ, Bixler A. 2024. Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study. CourseSource 11. https://doi.org/10.24918/cs.2024.3

• Froney, M.M., Jarstfer, M.B., Pattenden, S.G., Solem, A.C., Aina, O.O., Eslinger, M.R., Thomas, A., & Alexander, C.M. 2024. Behind the screen: drug discovery using the big data of phenotypic analysis. Frontiers in Education.

• Alexander, C.C., Gaudier-Diaz, M.M., Kleinschmit, A.J., Dihle, P.J., Salger, S.A., Vega, N.M., & Robertson, S.D. 2024. A case study to engage students in the research design and ethics of high-throughput metagenomics. Journal of Microbiology & Biology Education.

• Yu S, Weir SM. 2022. Pesticides in my smoothie bowl? CourseSource. https://doi.org/10.24918/cs.2022.26

• Goller CC, Johnson GT, Casimo K. 2022. Does organelle shape matter?: Exploring patterns in cell shape and structure with high-throughput (HT) imaging. CourseSource. https://doi.org/10.24918/cs.2022.3

• Goller C., Chen, S., Srougi M. 2021. New Tricks for Old Drugs: Using High-throughput Screening to Repurpose FDA-Approved Drugs to Combat Zika Virus. National Center for Case Study Teaching in Science. https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1194&id=1194

• Chen, S and Bixler, A. 2021. Directed Evolution of Nanobodies for COVID-19 Prevention. National Center for Case Study Teaching in Science. Available on the web: https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1186&id=1186

• Bixler A, Eslinger M, Kleinschmit AJ, Gaudier-Diaz MM, Sankar U, Marsteller P, Goller CC, Robertson S. 2021. Three Steps to Adapt Case Studies for Synchronous and Asynchronous Online Learning. J Microbiol Biol Educ. 2021 Mar 31;22(1):22.1.22. doi: 10.1128/jmbe.v22i1.2337. PMID: 33884065; PMCID: PMC8012036.

• Samsa LA, Eslinger M, Kleinschmit A, Solem A, Goller CC. 2021. Single-cell insights into cancer transcriptomes: A five-part single-cell RNAseq case study lesson. CourseSource. September 2021. 

• Garcia, J.M.* 2020. The Fight Against Bacteria. National Center for Case Study Teaching in Science. Published December 2020. Available on the web: https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1154&id=1154

• Miller H.B., Robertson S.D., Srougi M. 2020. Seq’ing the CURE: Standard Edition. National Center for Case Study Teaching in Science. Published November 2021. Available on the web: https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1202&id=1202

• Miller H.B., Robertson S.D., Srougi M. 2020. Seq’ing the CURE: Neuroscience Edition. National Center for Case Study Teaching in Science. Published November 2021. Available on the web: https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1203&id=1203

• Chen S., Goller C., Srougi M. 2020. COVID-19: Where Did You Come From, Where Did You Go? National Center for Case Study Teaching in Science. Available on the web: https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1125&id=1125

• Homesley, M*. 2018. Applying High-Throughput Analysis to Biofilms. National Center for Case Study Teaching in Science. Available on the web:
  http://sciencecases.lib.buffalo.edu/cs/collection/detail.asp?case_id=996&id=996

*Student-produced case as part of a class taught by HITS faculty.