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    Potential Scenario
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    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
    longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics
    Article or Presentation
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    2002-Patrick_Nelson-Alan_Perelson-Mathematical_analysis_of_delay_differential _equation_models_of_HIV-1_infection
    Models of HIV-1 infection that include intracellular delays are more accurate representations of the biology and change the estimated values of kinetic parameters when compared to models without delays.
    delayHIV-1T cellscombination antiviral therapy
    Potential Scenario
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    2017-Fred_Adler-Mathematically Modeling Asthma
    Our Asthma models have examined how a viral infection can tip the immune system into a different state, with the potential to predispose an individual to future asthma
    infectionasthmaimmune responserhinovirus
    Potential Scenario
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    2014-Wang-EtAl-Estimating Mixed-Effects Differential Equation Models
    When multiple replicates of measurements are available for the dynamic process, it is of great interest to estimate mixed-effects in the ODE model for the process. We propose a semiparametric method to estimate mixed-effects ODE models.
    pharmacokineticsdynamic modelssmoothingsplinemixed-effects modelsHiV combination therapy
    Potential Scenario
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    2016-Wilkie-EtAl-Using ODEs to Explore Cancer-Immune Dynamics and Tumor Dormancy
    Here we present a general method using ordinary differential equations (ODEs) to model and analyze cancer-immune interactions, and in particular, immune-induced tumor dormancy.
    cancertumor-inhibiting cytotoxic actiontumor-promoting inflammationimmune-induced tumor dormancytumor growth dynamics
    Potential Scenario
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    40

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    2009-Marten-EtAl-Derivation and analysis of an ordinary differential equation for epilepsy dynamics
    In this paper we describe how an ordinary differential equation model of corticothalamic interactions may be obtained from a more general system of delay differential equations.
    delayepilepsy dynamicsepilepsybistabilityseizure activity
    Potential Scenario
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    43

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    2001-Edwards-Buckmire-A differential equation model of North American cinematic box-office dynamics
    A new mathematical model is presented for the box-office dynamics of a motion picture released in North America.
    cinemamoviesbox-office
    Free Online Textbook
    163

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    58

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    2014-Andre_De Ross-Modeling Population Dynamics
    This course is intended as an introduction to the formulation, analysis and application of mathematical models that describe the dynamics of biological populations.
    predator-preycompetitionpopulationgrowthbifrucationtext
    Potential Scenario
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    2011-Therese-Keane-Combat modelling with partial differential equations
    We present work seeking to more realistically represent troop dynamics and to enable a deeper understanding of the nature of conflict.
    Lanchester modeltroop dynamicsswarming behaviortroop regroupinglossesnon-local termslocal terms
    Modeling Scenario
    462

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    130

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    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.
    cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy
    Potential Scenario
    148

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    51

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    2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
    We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the time course of an individual’s infection.
    stabilityresistancevirusdrugepidemic competitionimmune responserhinovirus
    Potential Scenario
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    60

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    2014-Murillo-EtAl-Vertical Transmission in a Two-Strain Model of Dengue Fever
    The model is used to show that lower transmission rates of DENV-2 Asian are sufficient for displacing DENV-2 American in the presence of vertical transmission.
    Peruvector-host modeldengueepidemmiologyvertical transmission
    Potential Scenario
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    61

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    2013-Gonzalez_Parra-Arenas-Mathematical Model for Social Security Systems with Dynamical Systems
    In this paper it is proposed a mathematical approach based on dynamic systems to study the effect of the increase in the Social Security normal retirement age on the worker and on the dynamics of retiree populations.
    dynamical systemsretirement modelSocial Security
    Potential Scenario
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    2013-Fathalla_Rihan-Delay Differential Equations in Biosciences - Parameter estimation and sensitivity analysis
    This is a review article to show that delay differential models have a richer mathematical framework (compared with models without memory or after-effects) and a better consistency with biological phenomena such dynamical diseases and cell growth...
    epidemiologysensitivityImmunologyphysiologyRK-methodstime-lags
    Potential Scenario
    148

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    44

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    2006-Ousmane_Mousa_Tessa-Mathematical model for control of measles by vaccination
    In this article, we use a compartmental mathematical model of the dynamics of measles spread within a population with variable size to provide this framework.
    vaccinationcompartmentherd immunitymeaslesoptimal strategy
    Potential Scenario
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    2018-Winkle-Igoshin-Bennett-Josic-Ott-Modeling_Mechanical_Interactions_in_Growing_Populations_of_Rod-Shaped_Bacteria
    Here, we present an agent-based model that allows growing cells to detect and respond to mechanical interactions.
    bacteriaagent-basedpopulationbrod-shapedcellular growth
    Potential Scenario
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    2017-Justin_Krueger-Parameter Estimation Methods for Ordinary Differential Equation Models with Applications to Microbiology
    We demonstrate the feasibility of principal differential analysis using simulation studies and then apply the method to intestinal and vaginal microbiota data.
    microbiologyLotka Volterrramicrobiota
    Potential Scenario
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    2014-Do-Lee-A Differential Equation Model for the Dynamics of Youth Gambling
    We examine the dynamics of gambling among young people aged 16–24 years, how prevalence rates of at-risk gambling and problem gambling change as adolescents enter young adulthood, and prevention and control strategies.
    reproductive numberGamblingepidemicsensitivity indexyouth gambling
    Potential Scenario
    140

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    55

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    2016-Lewnard-Townsend-Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
    Our analysis shows that historical datasets can yield powerful insights into the transmission dynamics of reemerging disease agents with which we have limited contemporary experience to guide quantitative modeling and inference.
    infectious diseasepVector-Borne Diseaselagueplague
    Modeling Scenario
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    5-024-PhGreatLakes
    In this teaching modeling scenario, we demonstrate how lessons on salt-tank compartmental modeling can be used to predict phosphorus levels in the Great Lakes.
    Great Lakeslimnologycomparmentpollutioncompartmental modelsphosphorous