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    Potential Scenario
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    1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
    For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not be used used for more complex multi-compartment...
    sum of square errorsleast squarespharmacokineticslineteicscompartmental modelsdirect search
    Modeling Scenario
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    6-019-EnablingEpidemicExploration-ModelingScenario
    We became aware of several interesting possibilities for a modeling opportunity with data and we invited you to explore the several routes to parameter estimation in a SIR model with respect to the data offered.
    Akaike Information CriterionMichaelis-Mentenepidemicsaturationgradientleast sum of square errors
    Potential Scenario
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    1984-W_Brunner-D__Focht-Deterministic Three-Half-Order Kinetic Model for Microbial Degradation
    The kinetics of mineralization of carbonaceous substrates has been explained by a deterministic model which is applicable to either growth or nongrowth conditions in soil.
    kineticsnonlinear regressionsum of square errorsMonodlinearizemineralizationsubstratescarbonaceous
    Modeling Scenario
    220

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    222

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    5-080-SpaceFlightRecolonize-ModelingScenario
    This project is a combination of differential equations, multi-variable calculus, and vector calculus with use of technology to model colonization of a new planet. Students solve a system of second order differential equations to model a planet
    optimizationsum of square errorsvector calculusLagrange multipliersline integrals
    Modeling Scenario
    651

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    398

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    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
    dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay
    Potential Scenario
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    2018-Adeniji-EtAl-InverseProblemHolling-TannerModel
    We consider the inverse problem of parameter identification of nonlinear system of ODEs for a specific case of complete information about solution of the Holling-Tanner model for finite number of points for the finite time interval.
    goal functionabsolute error curvesinvers methodholling-Tanner model
    Potential Scenario
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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The
    glucose tolerance testsum of squared residualsmultiple shooting methodcost function
    Modeling Scenario
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    5-077-MandMAttritionWarfare-ModelingScenario
    Students model attrition between two opposing forces using M&M candies and discover a system of linear differential equations of order one, often called the Lanchester equations.
    attritionLanchester modelpredator-predatorN-square Law
    Potential Scenario
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    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
    concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time
    Potential Scenario
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    2015-Zhang-EtAl-On the Selection of ODE Models with Application to Predator-Prey Dynamical Models
    We propose a computationally inexpensive approach that employs statistical estimation of the full model, followed by a combination of a least squares approximation (LSA) and the adaptive Lasso.
    least-squares approximationSpline modelingMonte Carlo simulationsvariable selectionadaptive LASSO
    Potential Scenario
    149

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    56

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    1975-Rodda-Sampson-Smith-The One-Compartment Open Model Parameter Estimation
    A new estimation procedure is proposed for estimating the parameters of the simplest pharmacokinetic model, the one-compartment open model.
    compartment modelpharmacokineticsnonlinear estimationone compartment model
    Potential Scenario
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    2017-Justin_Krueger-Parameter Estimation Methods for Ordinary Differential Equation Models with Applications to Microbiology
    We demonstrate the feasibility of principal differential analysis using simulation studies and then apply the method to intestinal and vaginal microbiota data.
    microbiologyLotka Volterrramicrobiota
    Potential Scenario
    240

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    2017-Xiang_Liu-Mathematical Studies of Optimal Economic Growth Model with Monetary
    In this paper, efforts will be made to study an extended Neoclassic economic growth model derived from Solow-Swan Model and Ramsey-Cass-Koopsman Model.
    Optimal Control TheoryJacobianSolow-Swan modelMonetary policyoptimal economic growth
    Technique Narrative
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    5-005-StiffDifferentialEquations-TechniqueNarrative
    This material introduces the topic of ``stiffness'' for a system of ordinary differential equations (ODE's), through a series of examples. Stiffness is a property that a system of ODE's may posses that make it difficult to solve numerically.
    Euler's methodexplicit methodsimplicit methodsstiffsitffnessstiff differential equationinstability
    Potential Scenario
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    46

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    2012-Greer-Palin-Students in Differential Equations and Epidemiology Model a Campus Outbreak of pH1N1
    We describe a semester-long collaboration between a mathematics class and a biology class. Students worked together to understand and model the trajectory of the pandemic H1N1, pH1N1, outbreak across campus in fall 2009.
    H1N1pandemicspreadoutbreakpH1N1
    Potential Scenario
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    2009-Schaffer-Bronnikova-Controlling malaria
    The present paper reviews potential control strategies from the viewpoint of mathematical epidemiology.
    epidemiologymalariabifurcationmosquitotransgenic mosquitoes
    Potential Scenario
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    2017-Helen-Byrne-Further Mathematics Biology
    These studies will be in the context of ecological, biological and biochemical applications.
    epidemicschemotaxisenzyme-substrateion channelsnerve pulsesgene proagationtumour
    Potential Scenario
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    2014-Vance-Eads-Sensitivity Analysis of a Three-Species Nonlinear Response Omnivory Model with Predator Stage Structure
    We investigate a three-species nonlinear response omnivory model incorporating stage structure in the top predator. The model consists of four coupled ordinary differential equations involving fourteen parameters.
    stage structuresensitivity analysismortalityomnivoreomnivory modelsearch rates
    Potential Scenario
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    2013-Fathalla_Rihan-Delay Differential Equations in Biosciences - Parameter estimation and sensitivity analysis
    This is a review article to show that delay differential models have a richer mathematical framework (compared with models without memory or after-effects) and a better consistency with biological phenomena such dynamical diseases and cell growth...
    epidemiologysensitivityImmunologyphysiologyRK-methodstime-lags
    Potential Scenario
    164

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    2014-Michael_Monagan-The Mortgage Payment Problem Approximating a Discrete Process with a Differential Equation
    In this article and a subsequent article I will give two non-standard examples that I've found helpful. The one presented here is a first order linear system. Second order systems and non-linear systems.
    compartmentheatinghouse