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    Potential Scenario
    135

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    44

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    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
    longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics
    Potential Scenario
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    2014-Do-Lee-A Differential Equation Model for the Dynamics of Youth Gambling
    We examine the dynamics of gambling among young people aged 16–24 years, how prevalence rates of at-risk gambling and problem gambling change as adolescents enter young adulthood, and prevention and control strategies.
    reproductive numberGamblingepidemicsensitivity indexyouth gambling
    Modeling Scenario
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    6-001-Epidemic-ModelingScenario
    This paper presents real-world data, a problem statement, and discussion of a common approach to modeling that data, including student responses. In particular, we provide time-series data on the number of boys bedridden due to an outbreak of...
    datadifference equationsparameter estimationcontinuousepidemicdiscreteboarding school
    Article or Presentation
    232

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    518

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    2020-TeachingModule-ModelingNonlethalInfluenzaEpidemic
    We discuss the modeling efforts and tools for success in modeling the spread of nonlethal influenza in an English boarding school
    moduleepidemicboarding schoolTeaching Module
    Potential Scenario
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    2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models
    For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer cells.
    cancertumorfittingagent-based
    Modeling Scenario
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    191

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
    wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue
    Modeling Scenario
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    217

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    1-078-MonodGrowthModel-ModelingScenario
    Students model growth of bacteria E. coli in a limiting nutrient environment using data from a historical study.
    bacterianutrient cyclesgrowthMonodconsumption
    Modeling Scenario
    310

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    329

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    5-024-PhGreatLakes
    In this teaching modeling scenario, we demonstrate how lessons on salt-tank compartmental modeling can be used to predict phosphorus levels in the Great Lakes.
    Great Lakeslimnologycomparmentpollutioncompartmental modelsphosphorous
    Potential Scenario
    146

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    55

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    2013-Greer-EtAl-Collaborative Understanding of Cyanobacteria in Lake Ecosystems
    We describe here a collaboration in which the mathematicians help collect data, the ecologists synthesize more data from model output than they can produce empirically, and the collaboration produces both mathematical approaches and field work.
    collaborationlakeecosystemcyanobacteriafield workcolonyGloeo
    Modeling Scenario
    633

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    373

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    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
    dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay
    Modeling Scenario
    222

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    340

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    6-019-EnablingEpidemicExploration-ModelingScenario
    We became aware of several interesting possibilities for a modeling opportunity with data and we invited you to explore the several routes to parameter estimation in a SIR model with respect to the data offered.
    Akaike Information CriterionMichaelis-Mentenepidemicsaturationgradientleast sum of square errors
    Modeling Scenario
    354

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    254

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    6-040-StruggleForExistence-ModelingScenario
    We use historical data from the 1930's in the Soviet Union and model competition between two species of yeast after modeling each species separately and estimate parameters
    competitionlogisticcarrying capacityparamecium
    Potential Scenario
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    41

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    1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
    This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference equation model.
    drugstwo compartmentcocainedemand
    Potential Scenario
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    46

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    1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
    Contains data on performance scores vs. plasma levels of LSD in human tissues.
    LSDtestingpharmacokineticsperformanceplasma level
    Modeling Scenario
    663

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    215

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    5-026-Evictions-ModelingScenario
    In this project, students develop two SIS models to study eviction trends in a population of non-homeowner households using an actual eviction rate. Students can calculate solutions, sketch the phase portrait, and determine long-term trends .
    carrying capacitycompartmentevictionhomeownerSIS modelhomelessness
    Article or Presentation
    291

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    894

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    2020-TeachingModule-SpreadOfCommonColdSimulation
    This simulation is meant to introduce the idea of a differential equation model and investigate the impact of heightened hygiene and decreased interactions on the spread of an infectious disease. The focus of this simulation is on the common cold.
    simulationmoduleinfectious diseasediseasespreadTeaching Modulespread of disease
    Modeling Scenario
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    172

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    5-023-FakingGause-ModelingScenario
    We use a fake or toy data set to permit discovery of the parameters in a two population protozoan model used to study paramecium and yeast competition in the 1930's studies of G. F. Gause in the Soviet Union.
    competitionlogisticyeastGauseparameciumpoplulation
    Modeling Scenario
    421

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    114

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    6-067-LotkaVolterra-ModelingScenario
    This modeling scenario guides students through the process of fitting the Lotka-Volterra model of two differential equations to a real time series observational data. Students use the capabilities of R and R studio.
    time seriesdatacompetitionLotka-Volterramodel fittingpredictiongauseRexperimental
    Potential Scenario
    175

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    47

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    2012-Transtrum-Qiu-Optimal experiment selection for parameter estimation in biological differential equation models
    We explore the question to what extent parameters can be efficiently estimated by appropriate experimental selection.
    experimental designsystems biologyAssociation & Data Fittingreaction ratesdecay rates
    Modeling Scenario
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    712

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    3-043-BallisticModeling-SpongeDart-ModelingScenario
    The goal of this project is for students to develop, analyze, and compare three different models for the flight of a sponge dart moving under the influences of gravity and air resistance.
    projectile motionair resistanceballisticsdimensional analysisNewtonian mechanicssponge dartNerf gunNerf dartBuckingham's Theorem