Skip to Main Content
Powered by QUBES

Resources

Text Search:
Applied Filters
    Potential Scenario
    146

    views

    82

    downloads

    0

    comments

    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticspharmacodynamicstherapeutic concentration rangedrug dispositiondrug response
    Potential Scenario
    260

    views

    93

    downloads

    0

    comments

    2018-David_Bourne-Pharmacokinetics – Source Material
    This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.
    boluspharmacokineticspharmacodynamicdrug distribution
    Modeling Scenario
    314

    views

    231

    downloads

    0

    comments

    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
    Potential Scenario
    103

    views

    38

    downloads

    0

    comments

    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
    Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate
    Modeling Scenario
    233

    views

    116

    downloads

    0

    comments

    1-080-DrugAdministration-ModelingScenario
    A simple drug administration situation is modeled with only two observations.
    decaybloodstreamdrugrate constantadminister
    Modeling Scenario
    310

    views

    241

    downloads

    0

    comments

    7-010-MultipleDoses-ModelingScenario
    Two multiple dose drug administration regimens are offered. A drug is to maintain a certain level (above a set minimum and below a set maximum) in the blood stream and one regimen involves bolus injections and another involves steady drip flow...
    drug discoverystep functiondoseDiracdrug administrationinverse Laplace Transformintraveneousbolussteady drip
    Modeling Scenario
    351

    views

    133

    downloads

    0

    comments

    1-131-CaffeineElimination-ModelingScenario
    We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    caffeineeliminationpharmacokineticsdrug
    Modeling Scenario
    261

    views

    185

    downloads

    0

    comments

    1-130-AspirinAbsorption-ModelingScenario
    We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    pharmacokineticsdrugaspirin
    Modeling Scenario
    340

    views

    537

    downloads

    0

    comments

    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Potential Scenario
    148

    views

    52

    downloads

    0

    comments

    2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
    We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the time course of an individual’s infection.
    stabilityresistancevirusdrugepidemic competitionimmune responserhinovirus
    Potential Scenario
    197

    views

    70

    downloads

    0

    comments

    2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
    anesthesiapharmacokineticspharmacodynamicanesthetic
    Modeling Scenario
    412

    views

    287

    downloads

    0

    comments

    1-138-InnerEarDrugDelivery-ModelingScenario
    Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation of variables or integrating factor.
    concentrationdrug deliveryinner earcochleahearing loss
    Modeling Scenario
    383

    views

    199

    downloads

    0

    comments

    1-016-DogDrugs-ModelingScenario
    We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.
    wild_dogsdrug discoveryhalf-lifepentobarbital sodiumanesthesia
    Potential Scenario
    123

    views

    105

    downloads

    0

    comments

    2015-G_Knott-Chemical Kinetics - Simple Binding F + G to and from B
    The study of this reaction, F + G goes to and from B, is common in chemistry and biochemistry. For example, F could be a hormone or drug and G the associated receptor sites.
    bindingreactionchemical kineticsdeterministicBiochem Labsprobabilistickinetic reaction
    Modeling Scenario
    656

    views

    402

    downloads

    0

    comments

    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
    dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay
    Modeling Scenario
    292

    views

    224

    downloads

    0

    comments

    1-108-PoissonProcess-ModelingScenario
    In this project students learn to derive the probability density function (pdf) of the Poisson distribution and the cumulative distribution (cdf) of the waiting time. They will use them to solve problems in stochastic processes.
    Probabilitysstochastic processesPoisson processwaiting timearrival
    Potential Scenario
    202

    views

    70

    downloads

    0

    comments

    2014-Eckhoff-EtAl-Fun with maths-exploring implications of mathematical models for malaria eradication
    . In this note, four examples demonstrate both the effects of model structures and assumptions and also the benefits of using a diversity of model approaches fomalaria eradication strategies.
    vaccinemalariamigrationeradicationseasonality
    Potential Scenario
    1249

    views

    47

    downloads

    0

    comments

    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    kineticsSAScompartmentpharmacokinetics
    Modeling Scenario
    344

    views

    142

    downloads

    0

    comments

    1-115-ModelingWithFirstOrderODEs-ModelingScenario
    Several models using first order differential equations are offered with some questions on formulating a differential equations model with solutions provided.
    bacteriafalling objectNewton's Law of Coolingdrugcoolingdrag
    Modeling Scenario
    1189

    views

    5496

    downloads

    0

    comments

    5-001-LSD-ModelingScenario
    We describe the use of a two compartment model of a linear system of first order linear differential equations to model lysergic acid diethylamide (LSD) in the body. We provide the data from the literature.
    LSDSpanishcompartmentpharmacokineticslysergic acid diethylamide