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    Potential Scenario
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    2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
    We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the time course of an individual’s infection.
    stabilityresistancevirusdrugepidemic competitionimmune responserhinovirus
    Potential Scenario
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    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
    longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics
    Potential Scenario
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    2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
    In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.
    optimal controldrug resistancepharmacokineticspharmacodynamicschemotherapy
    Modeling Scenario
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    3-027-BobbingDropping-ModelingScenario
    We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law of Motion and Archimedes' Principle.
    drug resistancedirectedbuoyancyfree fallstatic equilibriumdisplacement
    Potential Scenario
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    1994-Roland_Minton-A Progression of Projectiles-Examples from Sports
    There is a progression of complexity and issues in projectile motion modeling from no resistance, to resistance proportional to velocity, then to velocity squared,
    sportsresistanceprojectilebaseballdraglinear resistancequadratic resistancetennis
    Potential Scenario
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    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
    concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time
    Modeling Scenario
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    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
    Potential Scenario
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    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
    Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate
    Modeling Scenario
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    1-080-DrugAdministration-ModelingScenario
    A simple drug administration situation is modeled with only two observations.
    decaybloodstreamdrugrate constantadminister
    Modeling Scenario
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    7-010-MultipleDoses-ModelingScenario
    Two multiple dose drug administration regimens are offered. A drug is to maintain a certain level (above a set minimum and below a set maximum) in the blood stream and one regimen involves bolus injections and another involves steady drip flow...
    drug discoverystep functiondoseDiracdrug administrationinverse Laplace Transformintraveneousbolussteady drip
    Potential Scenario
    146

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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticspharmacodynamicstherapeutic concentration rangedrug dispositiondrug response
    Modeling Scenario
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    5-022-ColdPill-ModelingScenario
    A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
    ratesmedicinedrug discoverycompartmentcold pillgastrointestinalbloodstream
    Potential Scenario
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    2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying
    The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important challenges for the pharmaceutical industry.
    paracetamolpharmacokineticsstomachsmall intestinesulfapyridine
    Potential Scenario
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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticsdrugpharmacodynamics
    Modeling Scenario
    352

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    133

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    1-131-CaffeineElimination-ModelingScenario
    We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    caffeineeliminationpharmacokineticsdrug
    Potential Scenario
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    1999-Peter_Deuflhard-Differential Equations in Technology and Medicine
    It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.
    cancerdesigntumordrugpolymertherapy
    Modeling Scenario
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    1-130-AspirinAbsorption-ModelingScenario
    We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    pharmacokineticsdrugaspirin
    Modeling Scenario
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    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Potential Scenario
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    2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
    anesthesiapharmacokineticspharmacodynamicanesthetic
    Potential Scenario
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    2002-Chai-Optimal initial angle to fire a projectile
    Assume a projectile is fired without air resistance and lands at a height y above its initial vertical position. What is the optimal initial angle of firing to maximize the horizontal distance traveled by the projectile?”
    optimizationprojectile motionlaunch angle