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    Modeling Scenario
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    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.
    cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy
    Potential Scenario
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    53

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    2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
    We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the time course of an individual’s infection.
    stabilityresistancevirusdrugepidemic competitionimmune responserhinovirus
    Article or Presentation
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    989

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    2020-TeachingModule-SpreadOfCommonColdSimulation
    This simulation is meant to introduce the idea of a differential equation model and investigate the impact of heightened hygiene and decreased interactions on the spread of an infectious disease. The focus of this simulation is on the common cold.
    simulationmoduleinfectious diseasediseasespreadTeaching Modulespread of disease
    Modeling Scenario
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    1-046-GoingViral-ModelingScenario
    Students participate in a simulation of the spread of a viral disease in the classroom and model the process with a logistic differential equation. The simulation uses random numbers and the entire class participates.
    simulationmathematical modeldatalogisticrandom number generatorfittingrandom process
    Modeling Scenario
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    126

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    1-084-GoingViral-ModelingScenario
    Students employ randomization in order to create a simulation of the spread of a viral disease in a population (the classroom). Students then use qualitative analysis of the expected behavior of the virus to devise a logistic differential equation.
    simulationlogisticrandomfittingpartial fractions
    Potential Scenario
    259

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    67

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    2018-Van_Kinh Nguyen-Esteban_Hernandez-Vargas-Parameter estimation in mathematical models of viral infections using R
    Mathematical modeling has played a central role to understand mechanisms in different viral infectious diseases. In this approach, biological-based hypotheses are expressed via mathematical relations and then tested based on empirical data.
    simulationdiseasevirusviral infection
    Modeling Scenario
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    1-038-Ebola-ModelingScenario
    Students will use data published by the World Health Organization to model the 2014 outbreak of the Ebola virus in West Africa. We begin with a simple exponential growth model and move through the modeling process to the logistic growth model.
    population dynamicsdata analysisexponential growthEbolalogisticepidemic
    Potential Scenario
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    42

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    2008-Yang-EtAl-Differential Equation Model of HIV Infection of CD T-Cells with Delay 
    Abstract: An epidemic model of HIV infection of CD4+ T-cells with cure rate and delay is studied. We include a baseline ODE version of the model, and a differential-delay model with a discrete time delay.
    virusT cellsHopf bifurcationendemic equilibrium
    Potential Scenario
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    2014-Murillo-EtAl-Vertical Transmission in a Two-Strain Model of Dengue Fever
    The model is used to show that lower transmission rates of DENV-2 Asian are sufficient for displacing DENV-2 American in the presence of vertical transmission.
    Peruvector-host modeldengueepidemmiologyvertical transmission
    Modeling Scenario
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    713

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    6-015-CombatingEbolaEpidemic-ModelingScenario
    This project offers students a chance to make a policy recommendation based on analysis of a nonlinear system of differential equations (disease model). The scenario is taken from the fall of 2014 when the Ebola outbreak in West Africa.
    diseaseEbolaAnalysisPolicydecision
    Potential Scenario
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    105

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    2017-Fred_Adler-Mathematically Modeling Asthma
    Our Asthma models have examined how a viral infection can tip the immune system into a different state, with the potential to predispose an individual to future asthma
    infectionasthmaimmune responserhinovirus
    Modeling Scenario
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    152

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    6-003-SchoolFluEpidemic-ModelingScenario
    We offer a model of the spread of flu in a school dormitory and are asked to find when the flu levels reach their peak and explain long term behavior of the spread of the flu.
    infectionepidemicSIR modelflupeakschool children
    Potential Scenario
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    51

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    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
    longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics