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Downloads
Views
Date
Relevance
Modeling Scenario
477
views
196
downloads
0
comments
5-012-LipoproteinModeling-ModelingScenario
Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
wildlife
low-density-lipoprotein
tracer
compartment model
cholesterol
blood plasma
body tissue
Potential Scenario
165
views
45
downloads
0
comments
1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
p
Pharmacology
pharmacokinetics
lidocaine
Modeling Scenario
651
views
398
downloads
0
comments
5-011-ModelingIbuprofren-ModelingScenario
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
data
AIC
Akaike Information Criterion
absorption
sum of square errors
compartment model
ibuprofen
delay
Modeling Scenario
209
views
242
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Potential Scenario
160
views
48
downloads
0
comments
1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
Contains data on performance scores vs. plasma levels of LSD in human tissues.
LSD
testing
pharmacokinetics
performance
plasma level
Potential Scenario
282
views
72
downloads
0
comments
1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
LSD
correlation coefficient
compartment model
lysergic acid diethylamide
performance
test score
tissue concentration
Modeling Scenario
298
views
179
downloads
0
comments
5-010-DNADegradation-ModelingScenario
We ask students to use the system of first order linear differential equations given in a source paper and estimates of the data from laboratory procedures from a plot to estimate the parameters and complete the modeling process.
DNA\kinetis
plasma
rat
pharmacokinetis
Modeling Scenario
329
views
516
downloads
0
comments
5-005-Dialysis-ModelingScenario
We design a compartment model of a kidney dialysis machine and compare 3 and 9 compartments for the machine as well as determine the effect of change in one of the parameters in the model on the effectiveness to deliver quality dialysis.
countercurrent multiplier
kidney
dialysis
concurrent
compartment
Potential Scenario
185
views
74
downloads
0
comments
1996-D_Erdman-MM_Morelock-A Study of Kinetics
This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
simulation
kinetics
parameter estimation
Enzyme
substrate
savings
compartment
stomach
blood
ginseng
Potential Scenario
144
views
93
downloads
0
comments
2014-Hrydziuszko-EtAl-Mathematical Two-compartment Model of Human Cholesterol Transport
We develop a two-compartment mathematical model to investigate cholesterol transport in the circulatory system and its de novo synthesis in the liver.
metabolic syndrome
compartment
cholesterol
two-compartment model
cholesterol transport
Modeling Scenario
336
views
537
downloads
0
comments
1-132-DigoxinElimination-ModelingScenario
We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
nullclines
pharmacokinetics
digoxin
drug elimination
two compartment
Modeling Scenario
257
views
320
downloads
0
comments
1-160-HeartDeathRate-ModelingScenario
Students simulate experience from a given data set which represents the heart death rate during the period 2000 - 2010 using several approaches to include exponential decay, difference equation, differential equation, and parameter estimation...
data
heart death rate
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