Skip to Main Content
Powered by QUBES

Resources

Text Search:
Applied Filters
    Potential Scenario
    208

    views

    89

    downloads

    0

    comments

    1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
    Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed.
    LSDcompartmentpharmacokinetics
    Potential Scenario
    142

    views

    90

    downloads

    0

    comments

    2014-Hrydziuszko-EtAl-Mathematical Two-compartment Model of Human Cholesterol Transport
    We develop a two-compartment mathematical model to investigate cholesterol transport in the circulatory system and its de novo synthesis in the liver.
    metabolic syndromecompartmentcholesteroltwo-compartment modelcholesterol transport
    Potential Scenario
    280

    views

    70

    downloads

    0

    comments

    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
    LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration
    Modeling Scenario
    476

    views

    194

    downloads

    0

    comments

    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
    wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue
    Potential Scenario
    114

    views

    43

    downloads

    0

    comments

    1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
    This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference equation model.
    drugstwo compartmentcocainedemand
    Modeling Scenario
    354

    views

    206

    downloads

    0

    comments

    5-022-ColdPill-ModelingScenario
    A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
    ratesmedicinedrug discoverycompartmentcold pillgastrointestinalbloodstream
    Potential Scenario
    254

    views

    91

    downloads

    0

    comments

    2018-David_Bourne-Pharmacokinetics – Source Material
    This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.
    boluspharmacokineticspharmacodynamicdrug distribution
    Potential Scenario
    183

    views

    74

    downloads

    0

    comments

    1996-D_Erdman-MM_Morelock-A Study of Kinetics
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    simulationkineticsparameter estimationEnzymesubstratesavingscompartmentstomachbloodginseng
    Modeling Scenario
    290

    views

    225

    downloads

    0

    comments

    1-086-MedicinalPill-ModelingScenario
    Administration of a medicinal pill in single and multiple doses is modeled.
    medicinespillovercompartmentbloodstreamGIT-Track
    Potential Scenario
    153

    views

    62

    downloads

    0

    comments

    1984-Marguerite_Hays-Compartmental Models for Human Iodine Metabolism
    Compartmental models for the various aspects of human iodine metabolism are reviewed, emphasizing the role of Mones Berman in the development of this field.
    compartment modeliodinethyroid
    Modeling Scenario
    336

    views

    537

    downloads

    0

    comments

    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Modeling Scenario
    329

    views

    514

    downloads

    0

    comments

    5-005-Dialysis-ModelingScenario
    We design a compartment model of a kidney dialysis machine and compare 3 and 9 compartments for the machine as well as determine the effect of change in one of the parameters in the model on the effectiveness to deliver quality dialysis.
    countercurrent multiplierkidneydialysisconcurrentcompartment
    Modeling Scenario
    208

    views

    238

    downloads

    0

    comments

    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
    paracetamolanalgesicvegetariannon-vegetarian
    Potential Scenario
    276

    views

    75

    downloads

    0

    comments

    2014-Blomhøj-EtAl-Compartment models
    An overview of compartment models with many rich illustrations and much attention to various numerical methods in solutions of the resulting differential equations using Matlab. Also included is a section on the limitations of compartment models.
    concentrationkineticsphysiologycompartmentsalttankbalancereactionsminkbathtub
    Potential Scenario
    161

    views

    83

    downloads

    0

    comments

    2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS
    In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.
    SASsuperpositionpharmacokineticscompartmental modelsmultiple dose
    Potential Scenario
    163

    views

    74

    downloads

    0

    comments

    2014-Michael_Monagan-The Mortgage Payment Problem Approximating a Discrete Process with a Differential Equation
    In this article and a subsequent article I will give two non-standard examples that I've found helpful. The one presented here is a first order linear system. Second order systems and non-linear systems.
    compartmentheatinghouse
    Modeling Scenario
    650

    views

    394

    downloads

    0

    comments

    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
    dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay
    Modeling Scenario
    223

    views

    255

    downloads

    0

    comments

    6-029-TumorGrowth-ModelingScenario
    This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of tumor growth over time.
    Pop_Growth Pilotlogisticcomparmenttumorsynthetic datasum of squares error
    Modeling Scenario
    305

    views

    207

    downloads

    0

    comments

    1-051-OneTankSaltModel-ModelingScenario
    A large tank initially contains 60 pounds of salt dissolved into 90 gallons of water. Salt water flows in at a rate of 4 gallons per minute, with a salt density of 2 pounds per gallon. The incoming water is mixed in with the contents of the tank...
    compartmentsalttankmixingflow
    Modeling Scenario
    472

    views

    477

    downloads

    0

    comments

    1-042-KoolAid-ModelingScenario
    Students run experiments involving concentrated solution of drink powder flowing from upper to lower tank, initially filled with plain water. They make qualitative observations about the intensity of the color in the tanks, record data, and build...
    concentrationcompartmenttanksKoolAid