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Views
Date
Relevance
Potential Scenario
200
views
87
downloads
0
comments
1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed.
LSD
compartment
pharmacokinetics
Potential Scenario
247
views
89
downloads
0
comments
2018-David_Bourne-Pharmacokinetics – Source Material
This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.
bolus
pharmacokinetics
pharmacodynamic
drug distribution
Modeling Scenario
225
views
112
downloads
0
comments
1-080-DrugAdministration-ModelingScenario
A simple drug administration situation is modeled with only two observations.
decay
bloodstream
drug
rate constant
administer
Modeling Scenario
349
views
198
downloads
0
comments
5-022-ColdPill-ModelingScenario
A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
rates
medicine
drug discovery
compartment
cold pill
gastrointestinal
bloodstream
Modeling Scenario
292
views
106
downloads
0
comments
1-131-CaffeineElimination-ModelingScenario
We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
caffeine
elimination
pharmacokinetics
drug
Modeling Scenario
327
views
521
downloads
0
comments
1-132-DigoxinElimination-ModelingScenario
We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
nullclines
pharmacokinetics
digoxin
drug elimination
two compartment
Modeling Scenario
398
views
273
downloads
0
comments
1-138-InnerEarDrugDelivery-ModelingScenario
Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation of variables or integrating factor.
concentration
drug delivery
inner ear
cochlea
hearing loss
Modeling Scenario
375
views
199
downloads
0
comments
1-016-DogDrugs-ModelingScenario
We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.
wild_dogs
drug discovery
half-life
pentobarbital sodium
anesthesia
Potential Scenario
157
views
41
downloads
0
comments
1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
p
Pharmacology
pharmacokinetics
lidocaine
Potential Scenario
117
views
105
downloads
0
comments
2015-G_Knott-Chemical Kinetics - Simple Binding F + G to and from B
The study of this reaction, F + G goes to and from B, is common in chemistry and biochemistry. For example, F could be a hormone or drug and G the associated receptor sites.
binding
reaction
chemical kinetics
deterministic
Biochem Labs
probabilistic
kinetic reaction
Potential Scenario
106
views
41
downloads
0
comments
1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference equation model.
drugs
two compartment
cocaine
demand
Modeling Scenario
633
views
373
downloads
0
comments
5-011-ModelingIbuprofren-ModelingScenario
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
data
AIC
Akaike Information Criterion
absorption
sum of square errors
compartment model
ibuprofen
delay
Potential Scenario
126
views
47
downloads
0
comments
2011-GA_Koch-Noble-Drugs in the Classroom Using Pharmacokinetics to Introduce Biomathematical Modeling
By beginning with simple model involving the half-life of a drug, students take advantage of their mathematical abilities to explore the biology.
Biomathematics
pharmacokinetics
Modeling Scenario
201
views
227
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Potential Scenario
177
views
72
downloads
0
comments
1996-D_Erdman-MM_Morelock-A Study of Kinetics
This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
simulation
kinetics
parameter estimation
Enzyme
substrate
savings
compartment
stomach
blood
ginseng
Modeling Scenario
240
views
138
downloads
0
comments
3-027-BobbingDropping-ModelingScenario
We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law of Motion and Archimedes' Principle.
drug resistance
directed
buoyancy
free fall
static equilibrium
displacement
Potential Scenario
137
views
70
downloads
0
comments
2016-Roberto_Camporesi-A fresh look at linear ordinary differential equations with constant coefficients
We present an approach to the impulsive response method for solving linear constant-coefficient ordinary differential equations of any order based on the factorization of the differential operator.
impulse
Green functions
instructional exposition
Potential Scenario
149
views
60
downloads
0
comments
1984-Marguerite_Hays-Compartmental Models for Human Iodine Metabolism
Compartmental models for the various aspects of human iodine metabolism are reviewed, emphasizing the role of Mones Berman in the development of this field.
compartment model
iodine
thyroid
Potential Scenario
156
views
83
downloads
0
comments
2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS
In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.
SAS
superposition
pharmacokinetics
compartmental models
multiple dose
Article or Presentation
157
views
53
downloads
0
comments
2009-Agnes_Rash-Brian_Winkel-Birth_and_Death_Process_Modeling_Leads_to_the_Poisson_Distribution
In this paper there are details of development of the general birth and death process from which we can extract the Poisson process as a special case.
Probability
Mean
Poisson process
birth and death process
infinite number of differential equations
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