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    Potential Scenario
    160

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    48

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    1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
    Contains data on performance scores vs. plasma levels of LSD in human tissues.
    LSDtestingpharmacokineticsperformanceplasma level
    Modeling Scenario
    208

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    239

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    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
    paracetamolanalgesicvegetariannon-vegetarian
    Modeling Scenario
    476

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    194

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
    wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue
    Potential Scenario
    280

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    70

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    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
    LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration
    Modeling Scenario
    297

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    178

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    5-010-DNADegradation-ModelingScenario
    We ask students to use the system of first order linear differential equations given in a source paper and estimates of the data from laboratory procedures from a plot to estimate the parameters and complete the modeling process.
    DNA\kinetisplasmaratpharmacokinetis
    Potential Scenario
    164

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    44

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    1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
    Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
    pPharmacologypharmacokineticslidocaine
    Modeling Scenario
    650

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    394

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    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
    dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay
    Modeling Scenario
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    537

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    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Free Online Textbook
    127

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    51

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    1991-Carmine_Chicone-Ordinary Differential Equations with Applications
    This is a complete text for a graduate level course. Hence there is much theory, but there is a chapter on applications with some sophisticated approaches and high level modeling of motion.
    orbitstwo mass systematommagnetic fieldcoupled penduluminverted pendulumcharged particleKepler motion
    Modeling Scenario
    1093

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    179

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    3-051-ProjectileMotions-ModelingScenario
    We consider several instances of projectile flight without resistance, one on level ground and one from edge of cliff to determine maximum distance and placement.
    trajectorylaunching radiantprojectile motionprojectileno resistanceangle of launch
    Potential Scenario
    139

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    42

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    2010-Randy_Boucher-Determining Dissolved Oxygen Levels
    This is a full module given to students and the article contains comments for instructors as well.
    Environmental Engineeringbiochemical oxygen demandoxygen level
    Modeling Scenario
    402

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    500

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    1-047a-CondensationOptimization-ModelingScenario
    We seek to optimize a condensation process which is modeled by a simulation using the random motion of 200 particles in a 50 by 50 square in which a particle bounces off the two vertical and top walls and condenses on the bottom wall.
    simulationdataoptimizationenergycondensationbest fitcostsum of scquare errors
    Modeling Scenario
    354

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    206

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    5-022-ColdPill-ModelingScenario
    A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
    ratesmedicinedrug discoverycompartmentcold pillgastrointestinalbloodstream
    Potential Scenario
    172

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    51

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    2017-Sim-EtAl-Optimal control of a coupled tanks system with model-reality differences
    In this paper, an efficient computational approach is proposed to optimize and control a coupled tanks system.
    optimal controlflowtankscoupled tanks
    Potential Scenario
    132

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    49

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    2011-GA_Koch-Noble-Drugs in the Classroom Using Pharmacokinetics to Introduce Biomathematical Modeling
    By beginning with simple model involving the half-life of a drug, students take advantage of their mathematical abilities to explore the biology.
    Biomathematicspharmacokinetics
    Potential Scenario
    153

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    45

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    2011-Carl_Leinbach-Beyond Newton's law of cooling - estimation of time since death
    The paper offers an excellent history of temperature-based methods and then proceeds to demonstrate these with some data. Here the history is rich and will support student investigation as well as faculty development.
    time of deathNewton's aw of cooling
    Potential Scenario
    198

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    64

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    2011-Brian_Winkel-Parameter Estimates in Differential Equation Models for Population Growth
    We estimate the parameters present in several differential equation models of population growth, specifically logistic growth models and multiple species competition models.
    logisticpopulationparameciaGausegradient search
    Potential Scenario
    238

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    57

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    1967-JG-Wagner-Computers in pharmacokinetics
    This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.
    kineticscomputerspharmacokinetics
    Modeling Scenario
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    1-011A-Kinetics-ModelingScenario
    We help students see the connection between college level chemistry course work and their differential equations coursework. We do this through modeling kinetics, or rates of chemical reaction.
    kineticsLaw of Mass Actionfittingorder of reactionchemical reaction
    Modeling Scenario
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    3-027-BobbingDropping-ModelingScenario
    We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law of Motion and Archimedes' Principle.
    drug resistancedirectedbuoyancyfree fallstatic equilibriumdisplacement