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Downloads
Views
Date
Relevance
Potential Scenario
200
views
87
downloads
0
comments
1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed.
LSD
compartment
pharmacokinetics
Potential Scenario
139
views
87
downloads
0
comments
2014-Hrydziuszko-EtAl-Mathematical Two-compartment Model of Human Cholesterol Transport
We develop a two-compartment mathematical model to investigate cholesterol transport in the circulatory system and its de novo synthesis in the liver.
metabolic syndrome
compartment
cholesterol
two-compartment model
cholesterol transport
Potential Scenario
106
views
41
downloads
0
comments
1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference equation model.
drugs
two compartment
cocaine
demand
Potential Scenario
274
views
68
downloads
0
comments
1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
LSD
correlation coefficient
compartment model
lysergic acid diethylamide
performance
test score
tissue concentration
Modeling Scenario
327
views
521
downloads
0
comments
1-132-DigoxinElimination-ModelingScenario
We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
nullclines
pharmacokinetics
digoxin
drug elimination
two compartment
Potential Scenario
177
views
72
downloads
0
comments
1996-D_Erdman-MM_Morelock-A Study of Kinetics
This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
simulation
kinetics
parameter estimation
Enzyme
substrate
savings
compartment
stomach
blood
ginseng
Modeling Scenario
278
views
211
downloads
0
comments
1-086-MedicinalPill-ModelingScenario
Administration of a medicinal pill in single and multiple doses is modeled.
medicine
spillover
compartment
bloodstream
GIT-Track
Modeling Scenario
201
views
227
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Potential Scenario
268
views
74
downloads
0
comments
2014-Blomhøj-EtAl-Compartment models
An overview of compartment models with many rich illustrations and much attention to various numerical methods in solutions of the resulting differential equations using Matlab. Also included is a section on the limitations of compartment models.
concentration
kinetics
physiology
compartment
salt
tank
balance
reactions
mink
bathtub
Potential Scenario
156
views
70
downloads
0
comments
2014-Michael_Monagan-The Mortgage Payment Problem Approximating a Discrete Process with a Differential Equation
In this article and a subsequent article I will give two non-standard examples that I've found helpful. The one presented here is a first order linear system. Second order systems and non-linear systems.
compartment
heating
house
Modeling Scenario
217
views
228
downloads
0
comments
6-029-TumorGrowth-ModelingScenario
This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of tumor growth over time.
Pop_Growth Pilot
logistic
comparment
tumor
synthetic data
sum of squares error
Modeling Scenario
470
views
191
downloads
0
comments
5-012-LipoproteinModeling-ModelingScenario
Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
wildlife
low-density-lipoprotein
tracer
compartment model
cholesterol
blood plasma
body tissue
Modeling Scenario
349
views
198
downloads
0
comments
5-022-ColdPill-ModelingScenario
A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
rates
medicine
drug discovery
compartment
cold pill
gastrointestinal
bloodstream
Potential Scenario
156
views
83
downloads
0
comments
2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS
In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.
SAS
superposition
pharmacokinetics
compartmental models
multiple dose
Modeling Scenario
274
views
186
downloads
0
comments
1-025-MixingItUp-ModelingScenario
Students build three different models for levels of salt in a tank of water and at each stage the level of complexity increases with attention to nuances necessary for success.
compartment
salt
tank
mixing
Potential Scenario
157
views
41
downloads
0
comments
1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
p
Pharmacology
pharmacokinetics
lidocaine
Modeling Scenario
264
views
161
downloads
0
comments
5-025-SaltCompartments-ModelingScenario
Model a phenomena in which salt mixtures from two tanks are mixed using several strategies.
compartment
salt
tanks
Potential Scenario
195
views
69
downloads
0
comments
2017-GR_Gustafson-Differential Equations Course Materials
There are many applications from compartment and cascade analysis, recycling brine tank, home heating with multiple rooms, chemostat, microbes, heartbeats, lidocaine, nutrient flow in an aquarium, biomass transfer, pesticides, forecasting prices,...
chemostat
microbes
biomass
forecasting
transfer
compartment
pesticides
earthquake
tank
heating
lidocaine
brine
heartbeats
nutrient flow
aquarium
electric networks
circuits
logging
building
cascade
Potential Scenario
247
views
89
downloads
0
comments
2018-David_Bourne-Pharmacokinetics – Source Material
This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.
bolus
pharmacokinetics
pharmacodynamic
drug distribution
Potential Scenario
149
views
60
downloads
0
comments
1984-Marguerite_Hays-Compartmental Models for Human Iodine Metabolism
Compartmental models for the various aspects of human iodine metabolism are reviewed, emphasizing the role of Mones Berman in the development of this field.
compartment model
iodine
thyroid
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