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    Potential Scenario
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    2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models
    For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer cells.
    cancertumorfittingagent-based
    Potential Scenario
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    2012-Transtrum-Qiu-Optimal experiment selection for parameter estimation in biological differential equation models
    We explore the question to what extent parameters can be efficiently estimated by appropriate experimental selection.
    experimental designsystems biologyAssociation & Data Fittingreaction ratesdecay rates
    Modeling Scenario
    219

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    241

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    3-069-HeatInBar-ModelingScenario
    The temperature distribution along a uniform slender bar due to conduction and convection is investigated through experimental, analytical, and numerical approaches.
    heat transferexperimentconductionconvectionboundary conditionsfinite volume method
    Potential Scenario
    200

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    73

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    2017-D_Goulet-Modeling, Simulating, and Parameter Fitting of Biochemical Kinetic Experiments
    In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The differential equations are typically nonlinear.
    optimizationBiochemistrysensitivity analysischromatographymass actioncluster analysisconservation lawsdimerizationestrogen receptor protein
    Potential Scenario
    147

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    57

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    2017-Bonin-EtAl-Mathematical modeling based on ordinary differential equations - promising approach to vaccinology
    As a proof of concept, we developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature.
    immune systemyellow fevercomputational immunologycomputational vaccinology
    Potential Scenario
    161

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    82

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    2016-Bonin-EtAl-Mathematical modeling based on ordinary differential equations-vaccinology
    We developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature.
    Immunologyimmune systemAntigenvaccinologyyellow fever
    Potential Scenario
    128

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    48

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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The
    glucose tolerance testsum of squared residualsmultiple shooting methodcost function
    Potential Scenario
    142

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    63

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    2008-Ribbing-EtAl-Mathematical models of diabetes progression
    Writing a good model for diabetes progression is difficult because the long time span of the disease makes experimental verification of modeling hypotheses extremely awkward. underlying the
    physiologyclinical trialsdiabetesdiabetes progression
    Potential Scenario
    166

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    47

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    2006-Matt_MacWilliams-Developing ODEs to Describe the Motion of a Paper Helicopter
    This paper attempts to create a model that describes the motion of a paper helicopter using engineering, physical and statistical knowledge.
    experimental designhelicopter
    Potential Scenario
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    2000-deOlivera-Delfino-Costa-Leite-Pinhole Water Flow From Cylindrical Bottles
    The water flowing from the first bottle feeds the second one located below it. The same concepts of mass and energy conservation now lead to a non-trivial differential equation for the lowest bottle dynamics.
    Torricelli's LawConservation of EnergytConservation of MassBernoulli’s Theorem
    Potential Scenario
    202

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    74

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    1997-Jeff_Graham-Julia_Barnes-A Laboratory Experience for Students of Differential Equations Using RLC Circuits
    Acknowleging that applied mathematics courses rarely offer any hand-on experiences the authors constructed an RLC circuit from which they collected data and validated the differential equation of the RLC circuit.
    datacollectionslaboratorycircuitRLC
    Modeling Scenario
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    5485

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    5-001-LSD-ModelingScenario
    We describe the use of a two compartment model of a linear system of first order linear differential equations to model lysergic acid diethylamide (LSD) in the body. We provide the data from the literature.
    LSDSpanishcompartmentpharmacokineticslysergic acid diethylamide
    Technique Narrative
    424

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    206

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    2-005-LinearizeItAll-TechniqueNarrative
    Linear approximations are often used to simplify nonlinear ordinary differential equations (ODEs) for ease in analysis. The resulting linear approximation produces an ODE where closed form solutions may be obtained.
    computationerrorTorricelli's Lawdata fittinglinear approximation
    Potential Scenario
    170

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    45

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    2013-Boscolo-Stellato-Undergraduate study of harmonic and parametric motion of a simple spring-mass system from motion waveforms
    In this paper, we describe a laboratory exercise that caters to beginning students while giving those with more background an opportunity to explore more complex aspects of the motion.
    laboratoryexperimentspring massair frictionapparatuswaveforms
    Potential Scenario
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    67

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    2006-Graves-Peckham-Pastor-2D differential equations model for mutualism
    We develop from basic principles a two-species differential equations model which exhibits mutualistic population interactions.
    population dynamicsLotka-Volterragrowth ratemutualismLichen
    Potential Scenario
    119

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    51

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    2004-Aldo_Rescigno-On the use of pharmacokinetic models
    In this paper I will define in a simple and logical way a set of useful pharmacokinetic parameters and show how their estimation depends on the assumed model.
    compartmentsteady statepharmacokineticsvolume distribution
    Potential Scenario
    197

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    57

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    2003-Yildirim-Mackey-Feedback Regulation in the Lactose Operon
    A mathematical model for the regulation of induction in the lac operon in Escherichia coli is presented.
    mRNAlactoselactose operonfeedback regulation
    Modeling Scenario
    314

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    301

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    6-002-EulerCromerPendulum-ModelingScenario
    This activity introduces students to the concept of numerical stability. While modeling a simple pendulum, students compare performance of the semi-implicit Euler-Cromer method with Euler's method and the higher-order Improved Euleror algorithm.
    pendulumsemi-implicit methodsEuler-Cromernumerical solvers
    Modeling Scenario
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    255

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    6-029-TumorGrowth-ModelingScenario
    This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of tumor growth over time.
    Pop_Growth Pilotlogisticcomparmenttumorsynthetic datasum of squares error
    Modeling Scenario
    429

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    119

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    6-067-LotkaVolterra-ModelingScenario
    This modeling scenario guides students through the process of fitting the Lotka-Volterra model of two differential equations to a real time series observational data. Students use the capabilities of R and R studio.
    time seriesdatacompetitionLotka-Volterramodel fittingpredictiongauseRexperimental