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    Potential Scenario
    152

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    48

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    1999-Peter_Deuflhard-Differential Equations in Technology and Medicine
    It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.
    cancerdesigntumordrugpolymertherapy
    Modeling Scenario
    446

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    357

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    1-150-CancerTherapy-ModelingScenario
    This activity builds upon elementary models on population growth. In particular, we compare two different treatment models of cancer therapy where in one, surgery happens before therapy and in the other, surgery happens after therapy.
    population dynamicsphage therapyexponential growthcancerwater treatmentdecaysurgery
    Potential Scenario
    140

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    45

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    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
    longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics
    Potential Scenario
    172

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    67

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    2002-Nelson-Perelson-Mathematical analysis of delay differential equations models of HIV-1 infection
    We develop and analyze a set of models that include intracellular delays, combination antiretroviral therapy, and the dynamics of both infected and uninfected T cells.
    infectionHIVT cells
    Potential Scenario
    136

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    80

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    2014-Wang-EtAl-Estimating Mixed-Effects Differential Equation Models
    When multiple replicates of measurements are available for the dynamic process, it is of great interest to estimate mixed-effects in the ODE model for the process. We propose a semiparametric method to estimate mixed-effects ODE models.
    pharmacokineticsdynamic modelssmoothingsplinemixed-effects modelsHiV combination therapy
    Potential Scenario
    161

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    83

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    2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS
    In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.
    SASsuperpositionpharmacokineticscompartmental modelsmultiple dose
    Potential Scenario
    103

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    38

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    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
    Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate
    Potential Scenario
    135

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    51

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    2007-Zenker-Rubin-Clermont-From inverse problems in mathematical physiology to quantitative differential diagnoses
    The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data interpretation and decision making.
    physiologyinverse problem