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    Potential Scenario
    140

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    1975-Rodda-Sampson-Smith-The One-Compartment Open Model Parameter Estimation
    A new estimation procedure is proposed for estimating the parameters of the simplest pharmacokinetic model, the one-compartment open model.
    compartment modelpharmacokineticsnonlinear estimationone compartment model
    Modeling Scenario
    470

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
    wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue
    Potential Scenario
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    1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
    Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed.
    LSDcompartmentpharmacokinetics
    Potential Scenario
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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticsdrugpharmacodynamics
    Potential Scenario
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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticspharmacodynamicstherapeutic concentration rangedrug dispositiondrug response
    Modeling Scenario
    278

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    211

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    1-086-MedicinalPill-ModelingScenario
    Administration of a medicinal pill in single and multiple doses is modeled.
    medicinespillovercompartmentbloodstreamGIT-Track
    Modeling Scenario
    303

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    219

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    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
    Potential Scenario
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    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
    LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration
    Potential Scenario
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    2014-Michael_Monagan-The Mortgage Payment Problem Approximating a Discrete Process with a Differential Equation
    In this article and a subsequent article I will give two non-standard examples that I've found helpful. The one presented here is a first order linear system. Second order systems and non-linear systems.
    compartmentheatinghouse
    Modeling Scenario
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    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
    paracetamolanalgesicvegetariannon-vegetarian
    Potential Scenario
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    1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
    This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference equation model.
    drugstwo compartmentcocainedemand
    Potential Scenario
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    2015-Wrona-EtAl-Two-compartment model as a teaching tool for cholesterol homeostasis
    To investigate cholesterol transport in the circulatory system, we have previously developed a two-compartment mathematical model. Here, we show how this model can be used as a teaching tool for cholesterol homeostasis
    metabolic syndromecholesterolhigh blood cholesterolcholesterol homeostasis
    Potential Scenario
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    2018-David_Bourne-Pharmacokinetics – Source Material
    This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.
    boluspharmacokineticspharmacodynamicdrug distribution
    Potential Scenario
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    2017-GR_Gustafson-Differential Equations Course Materials
    There are many applications from compartment and cascade analysis, recycling brine tank, home heating with multiple rooms, chemostat, microbes, heartbeats, lidocaine, nutrient flow in an aquarium, biomass transfer, pesticides, forecasting prices,...
    chemostatmicrobesbiomassforecastingtransfercompartmentpesticidesearthquaketankheatinglidocainebrineheartbeatsnutrient flowaquariumelectric networkscircuitsloggingbuildingcascade
    Potential Scenario
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    1996-D_Erdman-MM_Morelock-A Study of Kinetics
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    simulationkineticsparameter estimationEnzymesubstratesavingscompartmentstomachbloodginseng
    Potential Scenario
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    2004-Aldo_Rescigno-On the use of pharmacokinetic models
    In this paper I will define in a simple and logical way a set of useful pharmacokinetic parameters and show how their estimation depends on the assumed model.
    compartmentsteady statepharmacokineticsvolume distribution
    Potential Scenario
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    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    kineticsSAScompartmentpharmacokinetics
    Potential Scenario
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    2009-Noakes-Sleigh-Mathematical models for assessing the role of airflow on the risk of airborne infection in hospital wards
    Understanding the risk of airborne transmission can provide important information for designing safe healthcare environments with an appropriate level of environmental control for mitigating risks.
    infectioncompartmenthospitalventilationairbornesthochasticWells–Riley
    Potential Scenario
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    2014-Blomhøj-EtAl-Compartment models
    An overview of compartment models with many rich illustrations and much attention to various numerical methods in solutions of the resulting differential equations using Matlab. Also included is a section on the limitations of compartment models.
    concentrationkineticsphysiologycompartmentsalttankbalancereactionsminkbathtub
    Potential Scenario
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    2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying
    The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important challenges for the pharmaceutical industry.
    paracetamolpharmacokineticsstomachsmall intestinesulfapyridine