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Downloads
Views
Date
Relevance
Potential Scenario
281
views
70
downloads
0
comments
1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
LSD
correlation coefficient
compartment model
lysergic acid diethylamide
performance
test score
tissue concentration
Potential Scenario
182
views
50
downloads
0
comments
2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
concentration
physiology
drugs
lag time
Extravascular
Pharamacokinetics
peak time
Potential Scenario
196
views
70
downloads
0
comments
2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
anesthesia
pharmacokinetics
pharmacodynamic
anesthetic
Modeling Scenario
310
views
228
downloads
0
comments
1-085-DrugBolus-ModelingScenario
Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
concentration
sum of square errors
bolus
drug
rate constant
administer
Potential Scenario
140
views
80
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
pharmacodynamics
therapeutic concentration range
drug disposition
drug response
Modeling Scenario
377
views
441
downloads
0
comments
1-011A-Kinetics-ModelingScenario
We help students see the connection between college level chemistry course work and their differential equations coursework. We do this through modeling kinetics, or rates of chemical reaction.
kinetics
Law of Mass Action
fitting
order of reaction
chemical reaction
Modeling Scenario
208
views
239
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Modeling Scenario
476
views
194
downloads
0
comments
5-012-LipoproteinModeling-ModelingScenario
Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
wildlife
low-density-lipoprotein
tracer
compartment model
cholesterol
blood plasma
body tissue
Potential Scenario
133
views
56
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
drug
pharmacodynamics
Potential Scenario
280
views
79
downloads
0
comments
2014-Blomhøj-EtAl-Compartment models
An overview of compartment models with many rich illustrations and much attention to various numerical methods in solutions of the resulting differential equations using Matlab. Also included is a section on the limitations of compartment models.
concentration
kinetics
physiology
compartment
salt
tank
balance
reactions
mink
bathtub
Modeling Scenario
266
views
387
downloads
0
comments
1-094-SteepingTea-ModelingScenario
We provide photographs of steeping process for a tea steeped in hot water. Students build a differential equation model for the steeping process and do parameter estimation using the color of our tea as a way to measure relative concentration.
concentration
Surface Area
color
Newton's Law of Cooling
tea
sugar
Potential Scenario
200
views
90
downloads
0
comments
1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and metabolism of the drug, as well as the subcellular...
mathematical model
data
LSD
Metabolism
bloodstream
lysergic acid diethylamide
distribution
Potential Scenario
1248
views
47
downloads
0
comments
2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
kinetics
SAS
compartment
pharmacokinetics
Potential Scenario
185
views
74
downloads
0
comments
1996-D_Erdman-MM_Morelock-A Study of Kinetics
This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
simulation
kinetics
parameter estimation
Enzyme
substrate
savings
compartment
stomach
blood
ginseng
Potential Scenario
136
views
73
downloads
0
comments
2016-Erno_Keszei-Chemical Kinetics for Beginners
The most important goal of kinetic research is the identification and characterisation of elementary molecular events which make possible the transformation of reactants into products.
kinetics
zeroth order reaction
first order reaction
second order reaction
reaction rates
third order reaction
Potential Scenario
172
views
44
downloads
0
comments
2015-Sivakumar-EtAl-Approximate Analytical Expression of Concentrations in a Kinetic Model for Biogas Generation from Banana Waste
The initial value problem in a kinetic model for biogas generation from banana waste is discussed. The model involves the system of non-linear differential equations which has variety of non-linear rate function.
chemical kinetics
Michaelis-Menten kinetics
anaerobic digestion
acidogenic steps
banana
methanogenic steps
wastes
Potential Scenario
130
views
74
downloads
0
comments
2015-Wrona-EtAl-Two-compartment model as a teaching tool for cholesterol homeostasis
To investigate cholesterol transport in the circulatory system, we have previously developed a two-compartment mathematical model. Here, we show how this model can be used as a teaching tool for cholesterol homeostasis
metabolic syndrome
cholesterol
high blood cholesterol
cholesterol homeostasis
Potential Scenario
307
views
54
downloads
0
comments
1976-JG-Wagner-Computers in pharmacokinetics
This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.
kinetics
computer
parameters
Pharmacology
drugs
pharmacokinetics
Potential Scenario
142
views
47
downloads
0
comments
2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical studyÂ
To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
longitudinal data
AIDS
antiretroviral drug therapy
Bayesian nonlinear mixed-effects
time-varying drug efficacy
HIV dynamics
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