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    Modeling Scenario
    476

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
    wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue
    Potential Scenario
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    1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
    This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference equation model.
    drugstwo compartmentcocainedemand
    Potential Scenario
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    1996-D_Erdman-MM_Morelock-A Study of Kinetics
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    simulationkineticsparameter estimationEnzymesubstratesavingscompartmentstomachbloodginseng
    Modeling Scenario
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    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Potential Scenario
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    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    kineticsSAScompartmentpharmacokinetics
    Modeling Scenario
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    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
    paracetamolanalgesicvegetariannon-vegetarian
    Potential Scenario
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    75

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    2014-Blomhøj-EtAl-Compartment models
    An overview of compartment models with many rich illustrations and much attention to various numerical methods in solutions of the resulting differential equations using Matlab. Also included is a section on the limitations of compartment models.
    concentrationkineticsphysiologycompartmentsalttankbalancereactionsminkbathtub
    Modeling Scenario
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    1-042-KoolAid-ModelingScenario
    Students run experiments involving concentrated solution of drink powder flowing from upper to lower tank, initially filled with plain water. They make qualitative observations about the intensity of the color in the tanks, record data, and build...
    concentrationcompartmenttanksKoolAid
    Potential Scenario
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    1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
    Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
    pPharmacologypharmacokineticslidocaine
    Potential Scenario
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    72

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    2017-GR_Gustafson-Differential Equations Course Materials
    There are many applications from compartment and cascade analysis, recycling brine tank, home heating with multiple rooms, chemostat, microbes, heartbeats, lidocaine, nutrient flow in an aquarium, biomass transfer, pesticides, forecasting prices,...
    chemostatmicrobesbiomassforecastingtransfercompartmentpesticidesearthquaketankheatinglidocainebrineheartbeatsnutrient flowaquariumelectric networkscircuitsloggingbuildingcascade
    Modeling Scenario
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    164

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    5-025-SaltCompartments-ModelingScenario
    Model a phenomena in which salt mixtures from two tanks are mixed using several strategies.
    compartmentsalttanks
    Potential Scenario
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    2016-Starling-EtAl-Local Brewery - A Project for Use in Differential Equations Courses
    We describe a modeling project designed for an ordinary differential equations (ODEs) course using first-order and systems of first-order differential equations to model the fermentation process in beer.
    BEERFermentationbrewery
    Modeling Scenario
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    1-093-SucroseReaction-ModelingScenario
    We offer data on the hydrolysis of sucrose in the presence of catalyst sucrase. We present students with several models and ask which model is best. We ask students to estimate parameters for the best model.
    kineticsMichaelis-Mentenhydrolysisreactionsucrose
    Potential Scenario
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    2010-Roberto_Munoz-Alicea-Mathematical Model for Enzyme Kinetics-Multiple Timescales Analysis
    We study a basic model for enzyme substrate reaction. Through several assumptions and via nondimensionalization, we simplify the equations.
    kineticsEnzymesubstratenondimensionalizationmultiple timescales
    Potential Scenario
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    48

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    1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
    Contains data on performance scores vs. plasma levels of LSD in human tissues.
    LSDtestingpharmacokineticsperformanceplasma level
    Potential Scenario
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    2012-Campbell-EtAl-Parameter estimation in differential equation models with constrained states
    We introduce a method to estimate parameters and states from a differential equation model while enforcing interpretability constraints such as monotone or non‐negative states.
    chemical engineeringsmoothing-based relaxation method
    Potential Scenario
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    2019-Radulescu-Lundgren-A_pharmacokinetic_model_of_lead_absorption_and_calcium_competitive_dynamics
    We build and analyze a compartmental model of lead pharmacokinetics, focused specifically on addressing neurotoxicity.
    QUBES Leadership Teamparametersabsorptionbifurcationpharmacokineticscalciumcognitive decline
    Modeling Scenario
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    5-010-DNADegradation-ModelingScenario
    We ask students to use the system of first order linear differential equations given in a source paper and estimates of the data from laboratory procedures from a plot to estimate the parameters and complete the modeling process.
    DNA\kinetisplasmaratpharmacokinetis
    Potential Scenario
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    1999-Kowalczyk-Hausknecht-Using DEs To Model Real World Data
    With the increasing availability of easy to use interactive differential equation software, we convinced ourselves to completely redesign the way we teach differential equations.
    circuitTorricelli's LawHooke's LawRC circuitharmonic oscillatorglucoseglucose tolerance test
    Modeling Scenario
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    1-011A-Kinetics-ModelingScenario
    We help students see the connection between college level chemistry course work and their differential equations coursework. We do this through modeling kinetics, or rates of chemical reaction.
    kineticsLaw of Mass Actionfittingorder of reactionchemical reaction